Designing
and
synthesizing
multishelled
metallic
hollow
nanostructures
with
intragaps
porous
shells
have
received
widespread
attention
for
enhancing
optical
catalytic
properties.
However,
significant
challenges
remain
in
engineering
these
structures
at
the
nanometer
scale.
Herein,
we
employed
galvanic
replacement
reaction
(GRR)
method
to
prepare
multimetallic
superstructures
3D
cavities
distinct
intragaps.
By
precise
control
of
intragap
distances
(1–10
nm)
composition
distributions
within
a
single
entity,
libraries
were
constructed.
Using
4-nitrophenol
reduction
as
model
reaction,
triple-shell
Au@Pt–Ag
nanoparticles
approximately
1
nm
exhibited
rate
211.6
times
higher
than
that
commercial
Pt/C
catalysts.
The
nanoconfinement
environment
not
only
increases
active
sites
but
also
promotes
electron
delocalization
reactants,
accelerating
hydrogenation
process
both
thermodynamically
kinetically.
Our
work
advances
rational
synthesis
nanostructures,
expanding
their
potential
applications
catalysis,
plasmonics,
biosensing.
Materials Advances,
Год журнала:
2024,
Номер
5(3), С. 986 - 1016
Опубликована: Янв. 1, 2024
The
bioengineering
of
phages
to
display
ligands
leads
specific
targeting,
reduced
toxicity,
enhanced
cellular
uptake
an
incorporated
drug/gene
and,
ultimately,
increased
therapeutic
efficacy.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 5, 2025
Abstract
Cisplatin
(CDDP)
combined
with
pemetrexed
(MTA)
is
commonly
employed
in
the
treatment
of
advanced
non‐small
cell
lung
cancer.
However,
conventional
clinical
administration
methods
fail
to
achieve
precise
spatiotemporal
delivery
within
tumor
microenvironment
(TME),
resulting
inadequate
control
local
drug
concentrations
and
impeding
synergistic
efficacy
chemotherapeutic
drugs.
Aiming
address
this
issue,
Fe
2
O
3
hollow
multi‐shelled
structure
(HoMS)
nanocarriers
spatiotemporally
controlled
release
properties
co‐encapsulated
CDDP
MTA
into
nanocarrier
are
developed.
The
confined
provided
by
‐HoMS
enables
a
targeted
temporal
sequential
tailored
requirements.
Furthermore,
chemotherapy‐induced
DNA
damage
leads
apoptosis,
accompanied
substantial
generation
reactive
oxygen
species
(ROS).
disruption
ROS
homeostasis
subsequently
activates
ferroptosis
pathway
mediated
‐HoMS.
In
summary,
exhibits
highly
two
drugs
TME,
HoMS
further
involved
regulation
ferroptosis,
realizing
triple
system
comprising
CDDP‐MTA‐Fe
2+
thus
significantly
enhancing
anti‐tumor
against
This
study
proposes
novel
approach
for
optimizing
design,
addressing
challenge
precisely
tumors.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 1401 - 1423
Опубликована: Фев. 1, 2025
Abstract:
Kidney
stones
constitute
a
common
condition
impacting
the
urinary
system.
In
clinical
diagnosis
and
management,
traditional
surgical
interventions
pharmacological
treatments
are
primarily
utilized;
however,
these
methods
possess
inherent
limitations.
Presently,
field
of
nanomedicine
is
undergoing
significant
advancements.
The
application
nanomaterials
in
biosensors
enables
accurate
assessment
ion
composition.
Furthermore,
contrast
agents
developed
from
materials
can
improve
signal-to-noise
ratio
enhance
image
clarity.
By
mitigating
oxidative
stress-induced
cellular
damage,
inhibit
formation
kidney
efficacy
drug
delivery
as
effective
carriers.
Additionally,
by
modifying
physical
chemical
properties
bacteria,
effectively
eliminate
bacterial
presence,
thereby
preventing
severe
complications.
This
review
explores
advancements
technology
related
to
early
detection
risk
factors,
diagnosis,
treatment
their
associated
Keywords:
nanomaterials,
stones,
stress,
biomaterial
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(31)
Опубликована: Апрель 14, 2023
Abstract
Hollow
structured
materials
with
easily
modifiable
surfaces
and
enclosed
interior
spaces
have
emerged
as
the
most
promising
candidates
in
drug
delivery
systems
(DDS).
With
various
functional
components
inspiring
cavities
for
creative
reinvention,
response
regulation
of
external
internal
microenvironment
hollow
structures
enable
their
ideal
capabilities
by
improving
aggregation
targeted
sites
maintaining
plasma
concentrations
at
optimal
therapeutic
ranges.
This
review
begins
an
in‐depth
explanation
interactions
release
mechanisms
structure‐based
DDS,
including
diffusion,
assembly,
solvent
activation,
chemical
control,
all
which
are
great
significance
design
smart
carriers.
Next,
recent
advances
microenvironment‐responsive
introduced,
based
on
signals
field
assists.
Focusing
unique
view
intra‐carrier
variability,
strategies
regulating
environment
then
highlighted,
pH
regulation,
temperature
mechanical
force
regulation.
Finally,
this
discusses
possible
challenges
prospects
structure‐based,
particularly
multishelled
intelligence‐responsive
platforms,
providing
valuable
development
next
generation
responsive
DDS.
Journal of Science Advanced Materials and Devices,
Год журнала:
2024,
Номер
9(3), С. 100770 - 100770
Опубликована: Июль 23, 2024
Due
to
the
non-specific
distribution
of
drugs
in
body
and
low
concentration
at
tumor
site
traditional
chemotherapy,
there
are
challenges
associated
with
significant
side
effects
resistance.
Therefore,
a
drug
delivery
system
(DDS)
urgently
needs
be
developed
that
can
precisely
target
tumors.
Metal-organic
frameworks
(MOFs)
possess
advantageous
characteristics
derived
from
organic
inorganic
materials,
including
small
particle
size,
large
specific
surface
area,
high
loading
capacity,
adjustable
structure
pore
as
well
ease
modification.
Consequently,
MOFs
offer
unique
advantages
for
designing
active
targeting,
passive
stimulus-responsive
targeting
strategies
have
become
hot
topic
current
research
on
tumor-targeted
systems.
This
review
will
elaborate
application
systems
perspective
different
strategies.
We
hope
this
paper
provide
assistance
therapy.
