Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 19, 2023
As
an
essential
micronutrient,
manganese
plays
important
role
in
the
physiological
process
and
immune
process.
In
recent
decades,
cGAS-STING
pathway,
which
can
congenitally
recognize
exogenous
endogenous
DNA
for
activation,
has
been
widely
reported
to
play
critical
roles
innate
immunity
against
some
diseases,
such
as
infections
tumor.
Manganese
ion
(Mn2+)
recently
proved
specifically
bind
with
cGAS
activate
pathway
a
potential
agonist,
however,
is
significantly
restricted
by
low
stability
of
Mn2+
further
medical
application.
one
most
stable
forms
manganese,
dioxide
(MnO2)
nanomaterials
have
show
multiple
promising
functions,
drug
delivery,
anti-tumor
anti-infection
activities.
More
importantly,
MnO2
are
also
found
be
candidate
agonist
transforming
into
Mn2+,
indicates
their
regulations
different
diseased
conditions.
this
review,
we
introduced
methods
preparation
well
biological
Moreover,
emphatically
discussed
detailed
mechanisms
activation
converting
Mn2+.
And
application
disease
treatment
regulating
might
benefit
future
development
novel
targeted
treatments
based
on
nanoplatforms.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 23, 2025
CGAS-STING
agonists
generally
lead
to
hyperimmunity
and
systemic
toxicity,
hindering
their
immunotherapeutic
outcomes.
Herein,
a
mitochondrion-targeted
nanoagonist
(termed
HABH)
containing
boron
dipyrromethene
(BODIPY)-derived
type
I
photosensitizer
(BDP)
Au
nanoparticle-engineered
hollow
mesoporous
silica
(HMSN/AuNPs)
has
been
fabricated
for
light-controlled
mitochondrial
stress-inducing
agonist-independent
cGAS-STING
pathway
activation.
The
HABH
can
actively
target
tumor
tissues
release
the
BDP.
Under
light
illumination,
BDP
achieves
photodynamic
therapy
(PDT)
in
mitochondria,
generating
massive
hydroxyl
radicals
(•OH)
inducing
stress
an
oxygen-independent
manner,
promoting
of
DNA
(mtDNA).
Simultaneously,
HMSN/AuNPs
act
as
dual
nanozymes
derive
cascade
reactions
•OH
production,
elevating
intracellular
oxidative
state,
together
with
BDP-induced
stress,
finally
evoking
facilitating
interferon.
In
orthotopic
breast
models,
achieved
intratumoral
immunoactivation
eradicating
primary
tumors
preventing
metastasis
tumors.
Therefore,
constructed
enabled
activation,
providing
paradigm
photoimmunotherapy.
Analytical Chemistry,
Год журнала:
2023,
Номер
95(17), С. 6854 - 6862
Опубликована: Апрель 7, 2023
Breakthroughs
in
immune
checkpoint
inhibitor
(ICI)
therapy
have
revolutionized
clinical
tumor
therapy.
Immunohistochemistry
(IHC)
analysis
of
PD-L1
tissue
has
been
used
to
predict
the
response
immunotherapy,
but
results
are
not
reproducible,
and
IHC
is
invasive
cannot
be
monitor
dynamic
changes
expression
during
treatment.
Monitoring
level
protein
on
exosomes
(exosomal
PD-L1)
promising
for
both
diagnosis
immunotherapy.
Here,
we
established
an
aptamer-bivalent-cholesterol-anchor
assembly
DNAzyme
(ABCzyme)
analytical
strategy
that
can
directly
detect
exosomal
with
a
minimum
lower
limit
detection
5.21
pg/mL.
In
this
way,
found
levels
significantly
elevated
peripheral
blood
patients
progressive
disease.
The
precise
by
proposed
ABCzyme
provides
potentially
convenient
method
monitoring
progression
who
receive
immunotherapy
proves
potential
effective
liquid
biopsy
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2023,
Номер
16(1)
Опубликована: Июль 2, 2023
Abstract
Natural
materials
and
bioprocesses
provide
abundant
inspirations
for
the
design
synthesis
of
high‐performance
nanomaterials.
In
past
several
decades,
bioinspired
nanomaterials
have
shown
great
potential
in
application
biomedical
fields,
such
as
tissue
engineering,
drug
delivery,
cancer
therapy,
so
on.
this
review,
three
types
strategies
nanomaterials,
that
is,
inspired
by
natural
structures,
biomolecules,
bioprocesses,
are
mainly
introduced.
We
summarize
discuss
concepts
approaches
various
along
with
their
specific
roles
applications.
Additionally,
we
challenges
development
mechanical
failure
wet
environment,
limitation
scale‐up
fabrication,
lack
deep
understanding
biological
properties.
It
is
expected
clinical
translation
will
be
further
promoted
under
cooperation
interdisciplinary
subjects
future.
This
article
categorized
under:
Implantable
Materials
Surgical
Technologies
>
Nanomaterials
Implants
Therapeutic
Approaches
Drug
Discovery
Emerging
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 19, 2023
As
an
essential
micronutrient,
manganese
plays
important
role
in
the
physiological
process
and
immune
process.
In
recent
decades,
cGAS-STING
pathway,
which
can
congenitally
recognize
exogenous
endogenous
DNA
for
activation,
has
been
widely
reported
to
play
critical
roles
innate
immunity
against
some
diseases,
such
as
infections
tumor.
Manganese
ion
(Mn2+)
recently
proved
specifically
bind
with
cGAS
activate
pathway
a
potential
agonist,
however,
is
significantly
restricted
by
low
stability
of
Mn2+
further
medical
application.
one
most
stable
forms
manganese,
dioxide
(MnO2)
nanomaterials
have
show
multiple
promising
functions,
drug
delivery,
anti-tumor
anti-infection
activities.
More
importantly,
MnO2
are
also
found
be
candidate
agonist
transforming
into
Mn2+,
indicates
their
regulations
different
diseased
conditions.
this
review,
we
introduced
methods
preparation
well
biological
Moreover,
emphatically
discussed
detailed
mechanisms
activation
converting
Mn2+.
And
application
disease
treatment
regulating
might
benefit
future
development
novel
targeted
treatments
based
on
nanoplatforms.
