Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics DOI Creative Commons

Tangxin Zhang,

Chunmiao Hu,

Wenting Zhang

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Апрель 19, 2023

As an essential micronutrient, manganese plays important role in the physiological process and immune process. In recent decades, cGAS-STING pathway, which can congenitally recognize exogenous endogenous DNA for activation, has been widely reported to play critical roles innate immunity against some diseases, such as infections tumor. Manganese ion (Mn2+) recently proved specifically bind with cGAS activate pathway a potential agonist, however, is significantly restricted by low stability of Mn2+ further medical application. one most stable forms manganese, dioxide (MnO2) nanomaterials have show multiple promising functions, drug delivery, anti-tumor anti-infection activities. More importantly, MnO2 are also found be candidate agonist transforming into Mn2+, indicates their regulations different diseased conditions. this review, we introduced methods preparation well biological Moreover, emphatically discussed detailed mechanisms activation converting Mn2+. And application disease treatment regulating might benefit future development novel targeted treatments based on nanoplatforms.

Язык: Английский

Mitochondrion‐Targeted Type I Photodynamic Therapy for Agonist Independent cGAS‐STING Activation DOI
Yin Xu,

Dongmin An,

Tian Zhang

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 23, 2025

CGAS-STING agonists generally lead to hyperimmunity and systemic toxicity, hindering their immunotherapeutic outcomes. Herein, a mitochondrion-targeted nanoagonist (termed HABH) containing boron dipyrromethene (BODIPY)-derived type I photosensitizer (BDP) Au nanoparticle-engineered hollow mesoporous silica (HMSN/AuNPs) has been fabricated for light-controlled mitochondrial stress-inducing agonist-independent cGAS-STING pathway activation. The HABH can actively target tumor tissues release the BDP. Under light illumination, BDP achieves photodynamic therapy (PDT) in mitochondria, generating massive hydroxyl radicals (•OH) inducing stress an oxygen-independent manner, promoting of DNA (mtDNA). Simultaneously, HMSN/AuNPs act as dual nanozymes derive cascade reactions •OH production, elevating intracellular oxidative state, together with BDP-induced stress, finally evoking facilitating interferon. In orthotopic breast models, achieved intratumoral immunoactivation eradicating primary tumors preventing metastasis tumors. Therefore, constructed enabled activation, providing paradigm photoimmunotherapy.

Язык: Английский

Процитировано

1

Manganese-based Virus-mimicking Nanomedicine with Triple Immunomodulatory Functions Inhibits Breast Cancer Brain Metastasis DOI
Zhenhao Zhao, Jingyi Zhou, Xu‐Wen Li

и другие.

Biomaterials, Год журнала: 2025, Номер unknown, С. 123262 - 123262

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1

Homogeneous, Simple, and Direct Analysis of Exosomal PD-L1 via Aptamer-Bivalent-Cholesterol-Anchor Assembly of DNAzyme (ABCzyme) for Tumor Immunotherapy DOI
Jie Hao, Junyi Wang, Yan Dong

и другие.

Analytical Chemistry, Год журнала: 2023, Номер 95(17), С. 6854 - 6862

Опубликована: Апрель 7, 2023

Breakthroughs in immune checkpoint inhibitor (ICI) therapy have revolutionized clinical tumor therapy. Immunohistochemistry (IHC) analysis of PD-L1 tissue has been used to predict the response immunotherapy, but results are not reproducible, and IHC is invasive cannot be monitor dynamic changes expression during treatment. Monitoring level protein on exosomes (exosomal PD-L1) promising for both diagnosis immunotherapy. Here, we established an aptamer-bivalent-cholesterol-anchor assembly DNAzyme (ABCzyme) analytical strategy that can directly detect exosomal with a minimum lower limit detection 5.21 pg/mL. In this way, found levels significantly elevated peripheral blood patients progressive disease. The precise by proposed ABCzyme provides potentially convenient method monitoring progression who receive immunotherapy proves potential effective liquid biopsy

Язык: Английский

Процитировано

15

Design and synthesis of bioinspired nanomaterials for biomedical application DOI
Kai Tang,

Jianmin Xue,

Yufang Zhu

и другие.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2023, Номер 16(1)

Опубликована: Июль 2, 2023

Abstract Natural materials and bioprocesses provide abundant inspirations for the design synthesis of high‐performance nanomaterials. In past several decades, bioinspired nanomaterials have shown great potential in application biomedical fields, such as tissue engineering, drug delivery, cancer therapy, so on. this review, three types strategies nanomaterials, that is, inspired by natural structures, biomolecules, bioprocesses, are mainly introduced. We summarize discuss concepts approaches various along with their specific roles applications. Additionally, we challenges development mechanical failure wet environment, limitation scale‐up fabrication, lack deep understanding biological properties. It is expected clinical translation will be further promoted under cooperation interdisciplinary subjects future. This article categorized under: Implantable Materials Surgical Technologies > Nanomaterials Implants Therapeutic Approaches Drug Discovery Emerging

Язык: Английский

Процитировано

14

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics DOI Creative Commons

Tangxin Zhang,

Chunmiao Hu,

Wenting Zhang

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Апрель 19, 2023

As an essential micronutrient, manganese plays important role in the physiological process and immune process. In recent decades, cGAS-STING pathway, which can congenitally recognize exogenous endogenous DNA for activation, has been widely reported to play critical roles innate immunity against some diseases, such as infections tumor. Manganese ion (Mn2+) recently proved specifically bind with cGAS activate pathway a potential agonist, however, is significantly restricted by low stability of Mn2+ further medical application. one most stable forms manganese, dioxide (MnO2) nanomaterials have show multiple promising functions, drug delivery, anti-tumor anti-infection activities. More importantly, MnO2 are also found be candidate agonist transforming into Mn2+, indicates their regulations different diseased conditions. this review, we introduced methods preparation well biological Moreover, emphatically discussed detailed mechanisms activation converting Mn2+. And application disease treatment regulating might benefit future development novel targeted treatments based on nanoplatforms.

Язык: Английский

Процитировано

13