Nano Energy, Год журнала: 2022, Номер 105, С. 108002 - 108002
Опубликована: Ноя. 9, 2022
Язык: Английский
ACS Nano, Год журнала: 2024, Номер 18(16), С. 10885 - 10901
Опубликована: Апрель 8, 2024
Hypochlorous acid (HClO), as a powerful oxidizer, is obtained from the oxidation of Cl- ions during electrochemical therapy (EChT) process for cancer therapy. However, extracellular generated HClO inadequate to inhibit effective tumor cell death. Herein, manganese-doped potassium chloride nanocubes (MPC NCs) fabricated and modified with amphipathic polymer PEG (PMPC function massive three-dimensional nanoelectrodes (NEs) were developed enhance generation immunotherapy under an alternating electric field. Under square-wave current (AC) field, was boosted by PMPC NEs due enlarged active surface area, enhanced mass transfer rate, improved electrocatalytic activity. Notably, upregulated intracellular concentration induce robust immunogenic death (ICD) AC Meanwhile, electric-triggered release Mn2+ effectively stimulated dendritic cells (DCs) maturation. In vivo results illustrated that PMPC-mediated EChT inhibited growth triggered promotion immune response regulate microenvironment. Based on potent antitumor immunity, further combined checkpoint inhibitor (αCTLA-4) realize EChT-immunotherapy, which demonstrated inhibition primary tumors abscopal effect distant tumors. To summarize, our work highlights application electrochemical-immunotherapy technology in
Язык: Английский
Процитировано
7
Advanced Materials, Год журнала: 2023, Номер 35(44)
Опубликована: Июль 21, 2023
Electronically controlled droplet manipulation has widespread applications in biochemistry, life sciences, and industry. However, current technologies such as electrowetting, electrostatics, surface charge printing rely on complex electrode arrays external power supplies, leading to inefficient manipulation. In light of these limitations, a novel method is proposed, which leverages tribo-electrophoresis (TEP) pipette an oil medium, thereby enabling human-droplet interactions be constructed with greater efficiency. The approach involves the rational design triboelectric nanogenerator-electrostatic tweezer that generates electric field improves maneuverability charged droplet, including aligned/non-aligned pipetting stable transport clamped state, can accomplished solely by hand motion. TEP not only provides droplets freedom move three dimensions but also offers feasibility case for chemical reactions liquid phase non-invasive sample extraction. This breakthrough establishes cornerstone capitalized nanogenerators, opening new avenues research
Язык: Английский
Процитировано
16
Small Methods, Год журнала: 2023, Номер 8(1)
Опубликована: Окт. 15, 2023
Abstract The efficacy of sonodynamic therapy (SDT) mainly relies on the sonosensitizers, which generate reactive oxygen species (ROS) upon ultrasound (US) stimulation. However, limited availability high‐efficiency sonosensitizers hampers therapeutic effectiveness SDT as a standalone modality. In this work, robust and gas cancer platform is constructed based strontium (Sr) doped barium titanate (BST) piezoelectric nanoparticles functionalized with L‐arginine (BST@LA). doping Sr into A site ABO 3 nanocrystals not only introduces vacancies enhance intrinsic piezoelectricity, but also narrows semiconductor band gap enhances charge carrier migration, all facilitate production superoxide anion (•O 2 − ) hydroxyl radical (•OH). addition, generated ROS promotes decomposition surface‐tethered LA, enabling controlled release nitric oxide (NO) at tumor site, thereby achieving combination effect. vivo experiments exhibit remarkable suppression rate (89.5%) in 4T1 mice model, demonstrating strategy. ion vacancy engineering to improve along synergistic therapy, provides promising avenues for improving therapy.
Язык: Английский
Процитировано
16
Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154499 - 154499
Опубликована: Авг. 3, 2024
Язык: Английский
Процитировано
6
Nano Energy, Год журнала: 2022, Номер 105, С. 108002 - 108002
Опубликована: Ноя. 9, 2022
Язык: Английский
Процитировано
23