Resources Chemicals and Materials,
Год журнала:
2024,
Номер
3(2), С. 103 - 122
Опубликована: Янв. 15, 2024
4,4-Difluoro-4-bora-3a,4a-diaza-sindacene
(BODIPY)
is
a
sort
of
photofunctional
dye
which
possesses
advantages
including
strong
light-capturing
property,
high
photon-resistance,
etc.
Meso-N
substituted
aza-BODIPY
crucial
derivative
BODIPY
scaffold
that
has
the
favorable
optical
properties
and
significant
spectral
redshift.
The
photophysical
can
be
tuned
by
molecular
design,
attenuation
path
excited
state
energy
release
absorbed
light
well
controlled
via
structural
modifications,
enabling
tailored
application.
It
been
extensively
employed
in
life
medicine
fields
fluorescence
imaging
diagnosis,
photodynamic
therapy
photosensitizer
photothermal
reagent
so
forth.
Extensive
research
review
have
performed
these
areas.
However,
BODIPYs/aza-BODIPYs
role
energy,
catalysis,
optoelectronics,
photo-responsive
materials
other
fields.
Nevertheless,
there
are
relatively
few
studies
reviews
on
modification
application
based
BODIPY/aza-BODIPY
scaffold.
Herein,
this
we
summarized
aforementioned
fields,
with
regulation
as
foundation
utilization
above
objective,
intention
providing
inspiration
for
exploration
innovative
field
resource
conversion
functional
materials.
Advanced Materials,
Год журнала:
2023,
Номер
36(21)
Опубликована: Июль 21, 2023
Abstract
Chemotherapy
is
widely
recognized
as
an
effective
approach
for
treating
cancer
due
to
its
ability
eliminate
cells
using
chemotherapeutic
drugs.
However,
traditional
chemotherapy
suffers
from
various
drawbacks,
including
limited
solubility
and
stability
of
drugs,
severe
side
effects,
low
bioavailability,
drug
resistance,
challenges
in
tracking
treatment
efficacy.
These
limitations
greatly
hinder
widespread
clinical
application.
In
contrast,
supramolecular
chemotherapy,
which
relies
on
host–guest
interactions,
presents
a
promising
alternative
by
offering
highly
efficient
minimally
toxic
anticancer
delivery.
this
review,
overview
recent
advancements
based
interactions
provided.
The
significant
role
it
plays
guiding
therapy
emphasized.
Drawing
wealth
cutting‐edge
research,
herein,
timely
valuable
resource
individuals
interested
the
field
or
therapy,
presented.
Furthermore,
review
contributes
progression
toward
Chemical Reviews,
Год журнала:
2024,
Номер
124(5), С. 2441 - 2511
Опубликована: Фев. 21, 2024
Boron-containing
compounds
(BCC)
have
emerged
as
important
pharmacophores.
To
date,
five
BCC
drugs
(including
boronic
acids
and
boroles)
been
approved
by
the
FDA
for
treatment
of
cancer,
infections,
atopic
dermatitis,
while
some
natural
are
included
in
dietary
supplements.
Boron's
Lewis
acidity
facilitates
a
mechanism
action
via
formation
reversible
covalent
bonds
within
active
site
target
proteins.
Boron
has
also
employed
development
fluorophores,
such
BODIPY
imaging,
carboranes
that
potential
neutron
capture
therapy
agents
well
novel
diagnostics
therapy.
The
utility
synthetic
become
multifaceted,
breadth
their
applications
continues
to
expand.
This
review
covers
many
uses
targets
boron
medicinal
chemistry.
Advanced Materials,
Год журнала:
2023,
Номер
36(1)
Опубликована: Авг. 1, 2023
Molecular
fluorophores
emitting
in
the
second
near-infrared
(NIR-II,
1000-1700
nm)
window
with
strong
optical
harvesting
and
high
quantum
yields
hold
great
potential
for
vivo
deep-tissue
bioimaging
high-resolution
biosensing.
Recently,
J-aggregates
are
harnessed
to
engineer
long-wavelength
NIR-II
emitters
show
unique
superiority
tumor
detection,
vessel
mapping,
surgical
navigation,
phototheranostics
due
their
bathochromic-shifted
bands
required
slip-stacked
arrangement
aggregation
state.
However,
despite
preliminary
progress
of
theoretical
study
structure-property
relationships,
further
paradigms
remain
scarce
lack
on
aggregated
fashion.
In
this
effort,
how
utilize
specific
molecular
structure
form
packing
motifs
J-type
exciton
coupling
is
emphatically
elucidated.
First,
several
regulating
strategies
achieve
containing
intermolecular
interactions
external
conditions
positively
summarized
deeply
analyzed.
Then,
recent
reports
theranostics
systematically
provide
a
clear
reference
direction
promoting
development
organic
fluorophores.
Eventually,
prospective
efforts
ameliorating
clinical
practices
outlined.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(8), С. 3976 - 4019
Опубликована: Янв. 1, 2024
This
review
focuses
on
the
design
strategy,
spectroscopic
characteristics,
and
functionalization
of
mitochondrion-targeted
BODIPY
dyes,
providing
an
overview
these
dyes
for
bioimaging
photodynamic
therapy.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(36)
Опубликована: Март 29, 2024
Abstract
Fluorescence
imaging
in
the
second
near‐infrared
window
(NIR‐II,
1000–1700
nm)
has
aroused
immense
attention
for
biomedical
applications,
offering
exceptional
advantages
such
as
ultra‐low
photon
scattering
and
increased
tissue
penetration.
Among
NIR‐II‐emitted
organic
dyes,
Boron
dipyrromethene
(BODIPY),
emerged
a
noteworthy
candidate.
BODIPY,
distinguished
by
its
controllable
molecular
structure
optical
properties,
outstanding
fluorescence
quantum
yields,
high
molar
absorption
coefficients,
remarkable
chemical
stability,
undergone
comprehensive
investigation
extensive
exploration
within
realm
of
biological
theranostics.
This
work
aims
to
provide
summary
advancements
development
design
strategies
NIR‐II
BODIPY
fluorophores
tailored
advanced
phototheranostics.
Initially,
elucidates
several
representative
strategies,
concluding
electron‐programming
strategy,
extension
conjugated
backbone,
J‐aggregation
strategic
establishment
activatable
fluorophores,
which
enhance
skeletons.
Subsequently,
developments
fluorescent
BODIPY‐based
nanoplatforms
applications
are
intricately
elaborated.
In
conclusion,
this
outlines
future
efforts
directions
refining
meet
evolving
clinical
demands.
It
is
anticipated
that
contribution
may
feasible
reference
thereby
advancing
their
potential
practices.
Molecules,
Год журнала:
2024,
Номер
29(5), С. 1168 - 1168
Опубликована: Март 6, 2024
Many
important
biological
species
have
been
identified
as
cancer
biomarkers
and
are
gradually
becoming
reliable
targets
for
early
diagnosis
late
therapeutic
evaluation
of
cancer.
However,
accurate
quantitative
detection
remains
challenging
due
to
the
complexity
systems
diversity
development.
Fluorescent
probes
extensively
utilized
identifying
substances
their
notable
benefits
being
non-invasive,
quickly
responsive,
highly
sensitive
selective,
allowing
real-time
visualization,
easily
modifiable.
This
review
critiques
fluorescent
used
detecting
imaging
over
last
five
years.
Focuses
made
on
design
strategies
small-molecule
nano-sized
probes,
construction
methods
fluorescence
sensing
platforms,
further
applications
in
multiple
biomarkers,
including
enzymes,
reactive
oxygen
species,
sulfur
microenvironments.
aims
guide
development
excellent
diagnostic
promote
broad
application
analysis
diagnosis.
