Turning on Singlet Oxygen Generation by Outer‐Sphere Microenvironment Modulation in Porphyrinic Covalent Organic Frameworks for Photocatalytic Oxidation

Angewandte Chemie International Edition, Год журнала: 2023, Номер 63(2)

Опубликована: Ноя. 29, 2023

Singlet oxygen (

Язык: Английский

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Bioorthogonal Guided Activation of cGAS‐STING by AIE Photosensitizer Nanoparticles for Targeted Tumor Therapy and Imaging

Advanced Materials, Год журнала: 2023, Номер 35(52)

Опубликована: Сен. 5, 2023

Abstract Photodynamic therapy (PDT) and photothermal (PTT) leverage reactive oxygen species (ROS) control local hyperthermia by photosensitizer to perturb intracellular redox equilibrium, inducing DNA damage in both mitochondria nucleus, activating the cGAS‐STING pathway, ultimately eliciting antitumor immune responses. However, current photosensitizers are encumbered limitations such as suboptimal tumor targeting, aggregation‐caused quenching (ACQ), restricted excitation emission wavelengths. Here, this work designs novel nanoparticles based on aggregation‐induced (AIE) (BODTPE) for targeted near‐infrared II fluorescence imaging (NIR‐II FLI) with enhanced PDT/PTT effects. BODTPE is employed a monomer, dibenzocyclooctyne (DBCO)‐PEG 2k ‐amine serving an end‐capping polymer, synthesize BODTPE‐containing polymer (DBD). Further, through self‐assembly, DBD mPEG‐DSPE combined form (NP‐DBD). Notably, DBCO surface of NP‐DBD can react azide groups cancer cells pretreated Ac 4 ManNAz copper‐free click reaction. This innovative formulation led accumulation within sites, phenomenon convincingly demonstrated murine models subjected N ‐azidoacetylmannosamine‐tetraacylated (Ac ManNAz) pretreatment. Significantly, exhibits multifaceted effect encompassing PDT/PTT/NIR‐II FLI upon 808 nm laser irradiation, thereby better culminating compelling inhibition augmented robust modulation.

Язык: Английский

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Afterglow bio-applications by utilizing triplet excited states of organic materials

Science China Chemistry, Год журнала: 2023, Номер 66(11), С. 2930 - 2940

Опубликована: Окт. 23, 2023

Язык: Английский

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Evolution of Aza-BODIPY dyes-A hot topic

Coordination Chemistry Reviews, Год журнала: 2023, Номер 498, С. 215428 - 215428

Опубликована: Окт. 1, 2023

Язык: Английский

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Phototherapy: progress, challenges, and opportunities

Science China Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Язык: Английский

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Dithio-Fused Boron Dipyrromethenes: Synthesis and Impact of S-Heteroaromatic Annulation Mode

Organic Letters, Год журнала: 2024, Номер 26(26), С. 5472 - 5477

Опубликована: Июнь 24, 2024

Three dithio-fused boron dipyrromethenes (BODIPYs), DTFB-1, DTFB-2, and DTFB-3, in which symmetrically S-heteroaromatic ring units fused at [a], zigzag, [b] bonds of the parent BODIPY core, respectively, were prepared from facile efficient post-functionalization tetra-halogenated BODIPYs through Pd-catalyzed cyclization. Dithio-fusion various positions effectively tunes their photophysical properties single-crystal structural packing arrangements. The single-crystalline microribbons DTFB-2 exhibit commendable hole mobilities air, reaching up to 0.03 cm2 V–1 s–1.

Язык: Английский

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Thiophene engineering of near-infrared D-π-A nano-photosensitizers for enhanced multiple phototheranostics and inhibition of tumor metastasis

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 685, С. 291 - 303

Опубликована: Янв. 17, 2025

Язык: Английский

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Fluorination of naphthalimide–cyanostilbene derivatives to achieve dual-state emission luminogens with strong fluorescence in highly polar environments for bioimaging

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(29), С. 6859 - 6867

Опубликована: Янв. 1, 2023

Organic luminogens (OLs) that emit strong fluorescence in both solution and the aggregated state, referred to as dual-state emission (DSEgens), are highly desirable because of their capability achieve multiple functions within onefold materials. The OLs, including DSEgens, with intramolecular charge transfer characteristics, often decreases solvent polarity increases, namely positive solvatokinetic effect, resulting inferior environmental stability. In this work, fluorination naphthalimide (NI)-cyanostilbene (CS) derivatives was adopted construct novel DSEgens (NICSF-X, X = B, P, M, T, respectively). Steady-state transient spectroscopies were utilized study photophysical properties, evidencing DSE properties quantum yields (φ) ∼0.2-0.4 ∼0.5-0.9 solids. particular, polar solvents i.e., φ up ∼0.4-0.5 ethanol, sustained for NICSF-Xs, possibly assisted by hydrogen bonding (H-bonding) formation. Theoretical calculations single-crystal structure analysis rationalized intense photoluminescence (PL) NICSF-Xs solid state. addition, showed two-photon absorption (2PA) behaviors dual states successfully applied HepG2 cell imaging one-photon 2PA excitation, lipid droplet targeting. Our suggests functionalization molecules introduce H-bonding is a promising strategy enhance stability realize PL solvents, which could be favorable bioimaging.

Язык: Английский

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Dynamic response and discrimination of gaseous sarin using a boron‐difluoride complex film‐based fluorescence sensor

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Июль 3, 2024

Abstract This study presents a novel boron‐difluoride complex‐based fluorescent nanofilm sensor capable of detecting sarin vapors in the environment by reporting an output fluorescence signal. The sensor's evaluation demonstrated exceptionally low detection limit for vapor, even presence various interfering gases, with theoretical and practical limits 0.7 1 ppb, respectively. featured rapid response time (less than 2 s), broad linear range (1 ppb–1000 ppm), superior selectivity vapor over group analytes, outperforming existing sensors. Mechanistic indicates that heightened sensitivity to is due robust affinity nitrogen atoms within core BODIQ unit sarin. Additionally, tetraphenylethylene structure steric hindrance effectively inhibits tight packing derivatives, forms numerous microporous structures self‐assembled nanofilm, which are beneficial mass transfer, enhancing efficiency vapors. Furthermore, we have achieved differentiation sarin, diethyl chlorophosphate, HCl through analysis sensing kinetic. opens new avenues sustainable, low‐cost, environment‐friendly portable devices, as well environmental monitoring tracking applications.

Язык: Английский

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Structural modification of A-C-A configured X–PCIC acceptor molecule for efficient photovoltaic properties with low energy loss in organic solar cells

Journal of Molecular Graphics and Modelling, Год журнала: 2024, Номер 129, С. 108722 - 108722

Опубликована: Фев. 7, 2024

Язык: Английский

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