bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
The
exponential
growth
of
scientific
publications
presents
opportunities
for
researchers
to
identify
valuable
knowledge,
especially
in
the
highly
interdisciplinary
field
---
biomaterials,
where
exploiting
possible
connections
between
unmet
clinical
needs
and
materials
properties
from
literatures
is
crucial.
However,
with
traditional
literature
reading,
it
extremely
challenging
marry
existing
reported
different
applications
or
other
purposes.
Here,
provide
a
not-renally
cleared
therapeutics
renally
impaired
hyperuricemia
patients,
we
designed
multi-tiered
framework
MatWISE
that
fuses
state-of-the-art
natural
language
processing,
semantic
relationship
mapping,
machine
learning
automate
complex
process
material
discovery
sea
published
until
December
2022,
successfully
identified
optimized
δ-MnO
2
into
an
orally
administered,
nonabsorbable
uric
acid
(UA)
lowering
biomaterial.
had
superior
serum
urine
UA-lowering
effect
three
mouse
models,
by
comparing
standard
care
drug.
promising
serve
as
safe
effective
drug
patients.
We
demonstrated
new
research
paradigm
biomaterials
combining
techniques
handful
experiments
discover
translationally
relevant
massive
research,
need.
Atmosphere,
Год журнала:
2024,
Номер
15(6), С. 689 - 689
Опубликована: Июнь 6, 2024
Accurate
and
rapid
weather
forecasting
climate
modeling
are
universal
goals
in
human
development.
While
Numerical
Weather
Prediction
(NWP)
remains
the
gold
standard,
it
faces
challenges
like
inherent
atmospheric
uncertainties
computational
costs,
especially
post-Moore
era.
With
advent
of
deep
learning,
field
has
been
revolutionized
through
data-driven
models.
This
paper
reviews
key
models
significant
developments
modeling.
It
provides
an
overview
these
models,
covering
aspects
such
as
dataset
selection,
model
design,
training
process,
acceleration,
prediction
effectiveness.
Data-driven
trained
on
reanalysis
data
can
provide
effective
forecasts
with
accuracy
(ACC)
greater
than
0.6
for
up
to
15
days
at
a
spatial
resolution
0.25°.
These
outperform
or
match
most
advanced
NWP
methods
90%
variables,
reducing
forecast
generation
time
from
hours
seconds.
reliably
simulate
patterns
decades
100
years,
offering
magnitude
savings
competitive
performance.
Despite
their
advantages,
have
limitations,
including
poor
interpretability,
evaluating
uncertainty,
conservative
predictions
extreme
cases.
Future
research
should
focus
larger
integrating
more
physical
constraints,
enhancing
evaluation
methods.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Окт. 25, 2023
Abstract
In-memory
computing
is
an
attractive
alternative
for
handling
data-intensive
tasks
as
it
employs
parallel
processing
without
the
need
data
transfer.
Nevertheless,
necessitates
a
high-density
memory
array
to
effectively
manage
large
volumes.
Here,
we
present
stacked
ferroelectric
comprised
of
laterally
gated
field-effect
transistors
(LG-FeFETs).
The
interlocking
effect
α-In
2
Se
3
utilized
regulate
channel
conductance.
Our
study
examined
distinctive
characteristics
LG-FeFET,
such
notably
wide
window,
effective
switching,
long
retention
time
(over
×
10
4
seconds),
and
high
endurance
5
cycles).
This
device
also
well-suited
implementing
vertically
structures
because
decreasing
its
height
can
help
mitigate
challenges
associated
with
integration
process.
We
devised
3D
structure
using
LG-FeFET
verified
feasibility
by
performing
multiply-accumulate
(MAC)
operations
in
two-tier
configuration.
Advanced Energy Materials,
Год журнала:
2023,
Номер
13(37)
Опубликована: Авг. 6, 2023
Abstract
Atomically
precise
composite
site‐based
catalysts
with
new
electrocatalytic
synergistic
mechanisms
and
enhanced
activities
have
emerged
as
a
frontier
in
the
electrocatalysis
community.
This
topical
review
focuses
on
recent
research
advances
of
atomically
metal
sites‐based
electrocatalysts.
work
first
demonstrates
an
overview
configurations
sites,
including
discussion
advanced
methods
employed
for
understanding
sites.
The
then
provides
comprehensive
organization
previously
reported
methodologies
synthesizing
electrocatalysts
Representative
case
studies
are
provided,
starting
from
simple
one‐step
pyrolysis
strategy
to
species‐by‐species
multi‐step
strategy.
Based
preceding
discussions
catalyst
materials,
further
discusses
unique
raised
by
that
different
routine
single
species
systems
mainly
involve
oxygen
reduction
reaction,
evolution
hydrogen
nitrogen
carbon
dioxide
reaction.
themes
this
section
include
true
active
center
determination
sites
various
types
synergy
mechanisms.
Finally,
critical
unanswered
questions
remaining
challenges,
well
promising
underexplored
directions
identified.
Advanced Materials,
Год журнала:
2024,
Номер
36(27)
Опубликована: Апрель 24, 2024
Abstract
Circulating
tumor
cells
(CTCs)
detection
presents
significant
advantages
in
diagnosing
liver
cancer
due
to
its
noninvasiveness,
real‐time
monitoring,
and
dynamic
tracking.
However,
the
clinical
application
of
CTCs‐based
diagnosis
is
largely
limited
by
challenges
capturing
low‐abundance
CTCs
within
a
complex
blood
environment
while
ensuring
them
alive.
Here,
an
ultrastrong
ligand,
l
‐histidine–
‐histidine
(HH),
specifically
targeting
sialylated
glycans
on
surface
CTCs,
designed.
Furthermore,
HH
integrated
into
cell‐imprinted
polymer,
constructing
hydrogel
with
precise
imprinting,
high
elasticity,
satisfactory
compatibility,
robust
anti‐interference
capacities.
These
features
endow
excellent
capture
efficiency
(>95%)
for
peripheral
blood,
as
well
ability
release
controllably
Clinical
tests
substantiate
accurate
differentiation
between
cancer,
cirrhosis,
healthy
groups
using
this
method.
The
remarkable
diagnostic
accuracy
(94%),
lossless
material
reversibility,
cost‐effectiveness
($6.68
per
sample)
make
HH‐based
potentially
revolutionary
technology
single‐cell
analysis.
Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Май 31, 2024
Artificial
intelligence
(AI)
has
recently
emerged
as
a
unique
developmental
influence
that
is
playing
an
important
role
in
the
development
of
medicine.
The
AI
medium
showing
potential
unprecedented
advancements
truth
and
efficiency.
intersection
to
revolutionize
drug
discovery.
However,
also
limitations
experts
should
be
aware
these
data
access
ethical
issues.
use
techniques
for
discovery
applications
increased
considerably
over
past
few
years,
including
combinatorial
QSAR
QSPR,
virtual
screening,
Virtual and Physical Prototyping,
Год журнала:
2023,
Номер
18(1)
Опубликована: Авг. 30, 2023
While
the
role
of
boron
(B)
has
been
thoroughly
clarified
in
titanium
(Ti)
castings,
microstructural
changes
triggered
additive
manufacturing
(AM)
are
still
subject
debate
literature.
Many
contributions
have
confirmed
B-induced
refinement
Ti-based
AM
parts.
The
formation
TiB
matrix
composites
(TMCs)
may
increase
strength.
In
some
cases,
B
also
promote
columnar-to-equiaxed
transition,
thus
mitigating
anisotropic
effects
associated
with
strong
epitaxial
growth
unidirectional
columnar
grains
typical
AM.
However,
as
critically
discussed
this
review,
pitfalls
remain.
Due
to
fast
cooling,
evolution
deviate
from
equilibrium,
leading
a
shift
Ti-B
eutectic
point
and
out-of-equilibrium
phases.
Additionally,
undermine
ductility
crack
propagation
resistance
parts,
which
calls
for
appropriate
remediation
strategies.
International Journal of Engineering,
Год журнала:
2024,
Номер
37(4), С. 579 - 587
Опубликована: Янв. 1, 2024
Composite
materials
are
the
most
important
in
science
and
engineering,
which
contain
two
or
more
materials.
In
scanning
electron
microscopy
(SEM)
technique
is
an
approach
to
measure
material''s
particle
size.
A
new
procedure
was
used
instead
of
SEM
called
Artificial
Intelligence
(AI).
(AI)
interdisciplinary
branch
computer
that
involves
solving
problems
require
human
intelligence
capabilities.
The
vision
a
subfield
AI,
uses
some
algorithms
detect
details
images
by
using
image
processing.
Detecting
particles
measuring
size
scanned
essential
task
helps
describe
their
feature,
traditionally,
calculated
manually
adding
mesh
drawing
diagonal
line
arbitrary
particle.
this
paper,
model
based
on
proposed
analyze
all
particles.
This
additives
composite
like
graphene
flakes
them
depending
reference
fixed
microscope
(SEM).
Open-source
Computer
Vision
(OpenCV)
library,
utilizing
multi-layers
canny
edge
detection,
Sobel
filter,
Brightness
contrast
algorithms,
Python
3.
results
have
achieved
very
satisfied
indication
with
low
process
time
=
0.2
mili-seconds.
Reviews in Physics,
Год журнала:
2024,
Номер
12, С. 100093 - 100093
Опубликована: Июнь 15, 2024
We
provide
a
perspective
on
the
fundamental
relationship
between
physics
and
computation,
exploring
conditions
under
which
physical
system
can
be
harnessed
for
computation
practical
means
to
achieve
this.
Unlike
traditional
digital
computers
that
impose
discrete
nature
continuous
substrates,
unconventional
computing
embraces
inherent
properties
of
systems.
Exploring
simultaneously
intricacies
implementations
applied
computational
paradigms,
we
discuss
interdisciplinary
developments
computing.
Here,
focus
potential
photonic
substrates
computing,
implementing
artificial
neural
networks
solve
data-driven
machine
learning
tasks.
Several
network
are
discussed,
highlighting
their
advantages
over
electronic
counterparts
in
terms
speed
energy
efficiency.
Finally,
address
challenges
achieving
programmability
within
outlining
key
strategies
future
research.
Advanced Energy Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 8, 2025
Abstract
The
precise
determination
of
ionization
energy
(IE)
and
electron
affinity
(EA)
is
crucial
for
the
development
optimization
organic
semiconductors
(OSCs).
These
parameters
directly
impact
performance
electronic
devices.
Experimental
techniques
to
measure
IE
EA,
such
as
UV
photoelectron
spectroscopy
(UPS)
low‐energy
inverse
(LE‐IPES),
are
accurate
but
resource‐intensive
limited
by
their
availability.
Computational
approaches,
while
beneficial,
often
rely
on
gas‐phase
calculations
that
fail
capture
solid‐state
phenomena,
leading
discrepancies
in
practical
applications.
In
this
work,
machine
learning
methods
used
develop
a
chained
model
estimating
EA
values.
By
implementing
transfer
strategy,
challenge
experimental
data
effectively
addressed,
utilizing
large
database
intermediate
properties
enhance
training.
efficacy
demonstrated
through
its
achieving
mean
absolute
errors
0.13
0.14
eV
respectively.
has
also
been
tested
an
external
validation
dataset
comprising
newly
measured
molecules.
findings
highlight
potential
OSC
research,
significantly
enhancing
property
accessibility
accelerating
molecular
design
discovery.