Small, Год журнала: 2024, Номер unknown

Опубликована: Май 21, 2024

Immuno-stimulative effect of chemotherapy (ISECT) is recognized as a potential alternative to conventional immunotherapies, however, the clinical application constrained by its inefficiency. Metronomic chemotherapy, though designed overcome these limitations, offers inconsistent results, with effectiveness varying based on cancer types, stages, and patient-specific factors. In parallel, wealth preclinical nanomaterials holds considerable promise for ISECT improvement modulating cancer-immunity cycle. area biomedical nanomaterials, current literature reviews mainly concentrate specific category nanotechnological perspectives, while two essential issues are still lacking, i.e., comprehensive analysis addressing causes inefficiency thorough summary elaborating improvement. This review thus aims fill gaps catalyze further development in this field. For first time, comprehensively discusses It then meticulously categorizes six types improving ISECT. Subsequently, practical strategies proposed inefficient ISECT, along detailed discussion exemplary nanomedicines. Finally, provides insights into challenges perspectives chemo-immunotherapy innovations nanomaterials.

Язык: Английский