The cGAS/STING Pathway—A New Potential Biotherapeutic Target for Gastric Cancer? DOI Open Access

Mengxiang Tian,

Shuai Zhang, Fengbo Tan

и другие.

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(7), С. 736 - 736

Опубликована: Июль 9, 2024

Gastric cancer ranks among the top five deadliest tumors worldwide, both in terms of prevalence and mortality rates. Despite mainstream treatments, efficacy treating gastric remains suboptimal, underscoring urgency for novel therapeutic approaches. The elucidation tumor immunosuppressive microenvironments has shifted focus towards biotherapeutics, which leverage patient’s immune system or biologics to target cells. Biotherapy emerged as a promising alternative resistant traditional chemotherapy, radiation, immunotherapy. Central this paradigm is cGAS-STING pathway, pivotal component innate system. This pathway recognizes aberrant DNA, such that from viral infections cells, triggers an response, thereby reshaping microenvironment into immune-stimulating milieu. In context cancer, harnessing holds significant potential biotherapeutic interventions. review provides comprehensive overview latest research on including insights clinical trials involving STING agonists. Furthermore, it assesses prospects targeting strategy cancer.

Язык: Английский

Profile of STING agonist and inhibitor research: a bibliometric analysis DOI Creative Commons
Xuemei Wang,

Qian Wang,

Yidan Gao

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 11, 2025

Background STING is a core signaling hub molecule in the innate immune system, involved various diseases, including infectious autoimmune tumors, aging, organ fibrosis, and neurodegenerative diseases. Its activation has shown great potential anti-tumor anti-infective therapies, with agonists emerging as promising approach cancer immunotherapy recent years. This study identifies research trends directions field by collecting analyzing relevant literature. Methods A total of 527 publications regarding 107 about inhibitors were retrieved from WOS Core Collection database. Bibliometric information was extracted CiteSpace VOSviewer software for visualization. Results It shows that on both burgeoning rapidly. The United States China are leading contributors this field. Application primarily focuses immunotherapy, while target inflammation, particularly neuroinflammation acute lung injury. Conclusion Current emphasizes optimizing permeability, efficacy, safety, nanotechnology lipid nanoparticles being prominent delivery techniques. Future expected to focus drug development clinical applications. comprehensive bibliometric analysis provides insights guide further investigation agonist/inhibitor.

Язык: Английский

Процитировано

1
Robust and Sustained STING Pathway Activation via Hydrogel-Based In Situ Vaccination for Cancer Immunotherapy DOI Creative Commons

Sheng‐Liang Cheng,

H.T. Lee,

Chung‐Pin Li

и другие.

ACS Nano, Год журнала: 2024, Номер 18(43), С. 29439 - 29456

Опубликована: Окт. 15, 2024

The stimulator of interferon genes (STING) pathway is crucial for tumor immunity, leading to the exploration STING agonists as potential immunotherapy adjuvants. However, their clinical application faces obstacles including poor pharmacokinetics, transient activation, and an immunosuppressive microenvironment (TME). Addressing these limitations, our study aims develop injectable silk fibroin hydrogel-based in situ vaccine. It incorporates a nanoscale agonist, immunogenic cell death (ICD) inducer, immunomodulator ensure controlled sustained release. cGAMP nanoparticles (cGAMPnps) with core–shell structure optimal delivery dendritic cells (DCs), thereby activating fostering DC maturation. ICD-associated damage-associated molecular patterns amplify prolong activation via enhanced type I IFN other inflammatory pathways, along delayed degradation STING. Furthermore, STING-driven vascular normalization by cGAMPnps ICD, conjunction immunomodulators like antiprogrammed protein 1 antibody (anti-PD-1 Ab) or OX40 ligand (OX40L), effectively remodels TME. This gel vaccine, when used independently surgery neoadjuvant/adjuvant immunotherapy, enhances CD8+ T-cell suppressing progression recurrence across various immunologically cold models. revolutionizes cancer offering substantial promise improving outcomes broad spectrum malignancies.

Язык: Английский

Процитировано

4
Advances in polymer nanomaterials targeting cGAS-STING pathway for enhanced cancer immunotherapy DOI
Shiyu Peng,

Xiaoxue Hou,

Jianfeng Liu

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Unleashing the Potential of Metal Ions in cGAS-STING Activation: Advancing Nanomaterial-Based Tumor Immunotherapy DOI Creative Commons

Xingyin Li,

Shaojie Xu,

Ziliang Su

и другие.

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Immunotherapy is a critical modality in cancer treatment with diverse activation pathways. In recent years, the stimulator of interferon genes (STING) signaling pathway has exhibited significant potential tumor immunotherapy. This exerts notable antitumor effects by activating innate and adaptive immunity regulating immune microenvironment. Various metal ions have been identified as effective activators STING and, through design synthesis nanodelivery platforms, applied immunotherapy well combination therapies, such chemotherapy, chemodynamic therapy, photodynamic vaccines. Metal nanomaterials showcase unique advantages immunotherapy; however, there are still aspects that require optimization. review systematically examines existing metal-based nanomaterials, elaborates on mechanisms which different activate pathway, discusses their application models therapies. We also provide comparative analysis over other methods. Our exploration highlights broad prospects treatment, offering new insights directions for advancement

Язык: Английский

Процитировано

0
Dual-modality immune nano-activator harnessing Mn2⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy DOI Creative Commons
Shanshan Ma, Xuequan Zhang, Xiaoqi Zhu

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 25, 2025

Manganese ions (Mn2+) have emerged as promising activators of the cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway. However, their clinical application was hindered by low bioavailability and limited immune activation pathways, which impaired ability to trigger robust responses achieve significant antitumor effects. To address these challenges, we developed a dual-modality nano-activator coordinating manganese with quercetin. This strategy designed enhance cGAS-STING pathway elicit immunogenic cell death, thereby strengthening response. The engineered demonstrated superior tumor-targeting efficient cellular internalization. Upon exposure near-infrared irradiation, system harnessed photothermal effects induce apoptosis in tumor cells while simultaneously accelerating release released facilitated generation reactive oxygen species, conjunction quercetin-induced apoptosis, amplified photothermal-induced DNA damage. damage further promoted cytosolic DNA, turn activated pathway, intensifying activation. Notably, also triggered synergized promote dendritic maturation activate antigen-specific T-cell, significantly enhancing response against tumor. Both vitro vivo studies confirmed that this effectively inhibited growth, particularly pronounced when combined anti-CTLA-4 antibodies.

Язык: Английский

Процитировано

0
In situ oxidation-responsive nanovaccine coordinates photosensitizer and STING agonist for cancer photo-immunotherapy DOI

Zhaochu Xu,

Jiang Yu, Yingxi Zhang

и другие.

Nano Today, Год журнала: 2025, Номер 62, С. 102726 - 102726

Опубликована: Март 26, 2025

Язык: Английский

Процитировано

0
Unveiling the crossroads of STING signaling pathway and metabolic reprogramming: the multifaceted role of the STING in the TME and new prospects in cancer therapies DOI Creative Commons
Siwei Wang, Qin Lu, Furong Liu

и другие.

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 7, 2025

The cGAS-STING signaling pathway serves as a critical link between DNA sensing and innate immunity, has tremendous potential to improve anti-tumor immunity by generating type I interferons. However, STING agonists have shown decreasing biotherapeutic efficacy in clinical trials. Tumor metabolism, characterized aberrant nutrient utilization energy production, is fundamental hallmark of tumorigenesis. And modulating metabolic pathways tumor cells been discovered therapeutic strategy for tumors. As research concerning progressed, emerging evidence highlights its role reprogramming, independent immune function, indicating targets activation cancers. In this review, we delve into the interplay multiple pathways. We also synthesize current knowledge on antitumor functions STING, within microenvironment (TME) that could be exploited activation. This review necessity future dissect complex interactions with various cancer types, emphasizing personalized strategies based profiling.

Язык: Английский

Процитировано

0
cGAS/STING signalling pathway in senescence and oncogenesis DOI
Le Yu, Pengda Liu

Seminars in Cancer Biology, Год журнала: 2024, Номер 106-107, С. 87 - 102

Опубликована: Авг. 31, 2024

Язык: Английский

Процитировано

3
The cGAS/STING Pathway—A New Potential Biotherapeutic Target for Gastric Cancer? DOI Open Access

Mengxiang Tian,

Shuai Zhang, Fengbo Tan

и другие.

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(7), С. 736 - 736

Опубликована: Июль 9, 2024

Gastric cancer ranks among the top five deadliest tumors worldwide, both in terms of prevalence and mortality rates. Despite mainstream treatments, efficacy treating gastric remains suboptimal, underscoring urgency for novel therapeutic approaches. The elucidation tumor immunosuppressive microenvironments has shifted focus towards biotherapeutics, which leverage patient’s immune system or biologics to target cells. Biotherapy emerged as a promising alternative resistant traditional chemotherapy, radiation, immunotherapy. Central this paradigm is cGAS-STING pathway, pivotal component innate system. This pathway recognizes aberrant DNA, such that from viral infections cells, triggers an response, thereby reshaping microenvironment into immune-stimulating milieu. In context cancer, harnessing holds significant potential biotherapeutic interventions. review provides comprehensive overview latest research on including insights clinical trials involving STING agonists. Furthermore, it assesses prospects targeting strategy cancer.

Язык: Английский

Процитировано

1