Recent Advancements in the Formulation of Nanomaterials-Based Nanozymes, Their Catalytic Activity, and Biomedical Applications

ACS Applied Bio Materials, Год журнала: 2023, Номер 6(9), С. 3577 - 3599

Опубликована: Авг. 17, 2023

Nanozymes are nanoparticles with intrinsic enzyme-mimicking properties that have become more prevalent because of their ability to outperform conventional enzymes by overcoming drawbacks related stability, cost, and storage. the potential manipulate active sites natural enzymes, which is why they considered promising candidates function as enzyme mimetics. Several microscopy- spectroscopy-based techniques been used for characterization nanozymes. To date, a wide range nanozymes, including catalase, oxidase, peroxidase, superoxide dismutase, designed effectively mimic enzymes. The activity nanozymes can be controlled regulating structural morphological aspects multifaceted benefits, exploited on large scale application in biomedical sector. versatility aids monitoring treating cancer, other neurodegenerative diseases, metabolic disorders. Due compelling advantages significant research advancements made this area. Although act potent mimetics specificities suboptimal, there still room diversification analytical purposes. Designing diverse nanozyme systems sensitive one or substrates through specialized has subject an in-depth study. Hence, we believe stimuli-responsive may open avenues diagnosis treatment fusing catalytic nanomaterial systems.

Язык: Английский

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Prussian blue nanozymes: progress, challenges, and opportunities

Nanoscale, Год журнала: 2023, Номер 15(31), С. 12818 - 12839

Опубликована: Янв. 1, 2023

Prussian Blue Nanozymes (PBNZs) have emerged as highly efficient agents for reactive oxygen species (ROS) elimination, owing to their multiple enzyme-like properties encompassing catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activities. As a functional nanomaterial mimicking enzyme, PBNZs not only surmount the limitations of natural enzymes, such instability high manufacturing costs, but also exhibit superior stability, tunable activity, low storage expenses, remarkable reusability. Consequently, gained significant attention in diverse biomedical applications, including disease diagnosis therapy. Over past decade, propelled by advancements catalysis science, biotechnology, computational nanotechnology, witnessed progress exploration enzymatic activities, elucidation catalytic mechanisms, wide-ranging applications. This comprehensive review aims provide systematic overview discovery mechanisms PBNZ, along with strategies employed modulate Furthermore, we extensively survey recent utilizing scavenging ROS various Lastly, analyze existing challenges translating into therapeutic clinical use outline future research directions this field. By presenting synopsis current state knowledge, seeks contribute deeper understanding immense potential an innovative agent biomedicine.

Язык: Английский

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Nanozymes‐Mediated Cascade Reaction System for Tumor‐Specific Diagnosis and Targeted Therapy

Small Methods, Год журнала: 2024, Номер unknown

Опубликована: Март 13, 2024

Abstract Cascade reactions are described as efficient and versatile tools, organized catalytic cascades can significantly improve the efficiency of chemical interworking between nanozymes. They have attracted great interest in many fields such chromogenic detection, biosensing, tumor diagnosis, therapy. However, how to selectively kill cells by enzymatic without harming normal cells, well exploring two or more enzyme‐engineered nanoreactors for cascading reactions, remain challenges field targeted specific cancer diagnostics The latest research advances nanozyme‐catalyzed cascade processes diagnosis therapy this article. Here, various sensing strategies summarized, tumor‐specific diagnostics. Targeting mechanisms treatment using nanozymes classified analyzed, “elements” “dimensions” nanozymes, types, designs structure, assembly modes highly active a variety new targeting based on reaction Finally, integrated application systems tumor‐targeted diagnostic is which will lay foundation design rational, efficient, therapeutic modalities future.

Язык: Английский

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Catalytic Nanoparticles in Biomedical Applications: Exploiting Advanced Nanozymes for Therapeutics and Diagnostics

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Апрель 29, 2024

Catalytic nanoparticles (CNPs) as heterogeneous catalyst reveals superior activity due to their physio-chemical features, such high surface-to-volume ratio and unique optical, electric, magnetic properties. The CNPs, based on nature, can either increase the reactive oxygen species (ROS) level for tumor antibacterial therapy or eliminate ROS cytoprotection, anti-inflammation, anti-aging. In addition, catalytic of nanozymes specifically trigger a specific reaction accompanied by optical feature change, presenting feasibility biosensor bioimaging applications. Undoubtedly, CNPs play pivotal role in pushing evolution technologies medical clinical fields, advanced strategies nanomaterials rely input chemical experts develop. Herein, systematic comprehensive review challenges recent development biomedical applications is presented from viewpoint nanomaterial with additional functions. Furthermore, biosafety issue applying biodegradable non-biodegradable future perspectives are critically discussed guide promising direction developing span-new more intelligent overcoming current limitations.

Язык: Английский

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Multifunctional iron-apigenin nanocomplex conducting photothermal therapy and triggering augmented immune response for triple negative breast cancer

International Journal of Pharmaceutics, Год журнала: 2024, Номер 655, С. 124016 - 124016

Опубликована: Март 19, 2024

Язык: Английский

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Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy

Chemical Society Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Язык: Английский

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pH-Responsive injectable self-healing hydrogels loading Au nanoparticles-decorated bimetallic organic frameworks for synergistic sonodynamic-chemodynamic-starvation-chemo therapy of cancer

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 675, С. 746 - 760

Опубликована: Июль 9, 2024

Язык: Английский

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Single‐Atom Cu Nanozyme‐Loaded Bone Scaffolds for Ferroptosis‐Synergized Mild Photothermal Therapy in Osteosarcoma Treatment

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(15)

Опубликована: Март 1, 2024

Abstract The rapid multiplication of residual tumor cells and poor reconstruction quality new bone are considered the major challenges in postoperative treatment osteosarcoma. It is a promising candidate for composite scaffold which combines photothermal therapy (PTT) regeneration induction local However, it inevitable to damage normal tissues around due hyperthermia PTT, while mild heat shows limited effect on antitumor as can be easily repaired by stress‐induced shock proteins (HSP). This study reports type single‐atom Cu nanozyme‐loaded scaffolds, exhibit exceptional conversion properties well peroxidase glutathione oxidase mimicking activities vitro experiments. leads lipid peroxidation (LPO) reactive oxygen species (ROS) upregulation, ultimately causing ferroptosis. accumulation LPO ROS also contributes HSP70 inactivation, maximizing PTT efficiency against tumors at an appropriate therapeutic temperature minimizing surrounding tissues. Further, promotes via continuous release bioactive ions (Ca 2+ , P 5+ Si 4+ ). results vivo experiments reveal that scaffolds inhibit growth promote repair.

Язык: Английский

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Tumor Microenvironment‐Driven Structural Transformation of Vanadium‐Based MXenzymes to Amplify Oxidative Stress for Multimodal Tumor Therapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

MXenzymes, a promising class of catalytic therapeutic material, offer great potential for tumor treatment, but they encounter significant obstacles due to suboptimal efficiency and kinetics in the microenvironment (TME). Herein, this study draws inspiration from electronic structure transition metal vanadium, proposing leverage TME specific-features induce structural transformations sheet-like vanadium carbide MXenzymes (TVMz). These trigger cascading reactions that amplify oxidative stress, thereby significantly enhancing multimodal therapy. Specifically, engineered HTVMz, coated with hyaluronic acid, exhibits good stability generates thermal effect under NIR-II laser irradiation. The effect, combined characteristics, facilities transformation into ultra-small oxide nanozymes (VOx). enlarged surface area VOx substantially enhances ROS regeneration amplifies which promotes lysosomal permeability induces endoplasmic reticulum stress. high-valent interacts intracellular glutathione, disrupting redox homeostasis intensifying stress further. amplifications accelerate apoptosis, ferroptosis, suppress HSP90 expression. Consequently, heightened sensitivity HTVMz synergistically cell death via pathways. This presents an innovative strategy therapy by manipulating structures, advancing field

Язык: Английский

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Biomimetic Nanoparticles-Enhanced Photothermal Immunotherapy: Targeted Delivery of NIR-II Agents and Immunoadjuvants for Tumor Immunogenicity

Biomaterials Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Advancing at the cutting edge of oncology, synergistic application photothermal therapy coupled with immunotherapy is rapidly establishing itself as an innovative and potent strategy against cancer. A critical challenge in this domain precise efficient targeting tumor tissues agents immunoadjuvants while minimizing interference healthy tissues. In paper, we introduce ingenious biomimetic nanoparticle platform, cancer cell membrane coated F127/(R837 IR1048) (CFRI) nanoparticles encapsulating a near-infrared region II agent, IR1048, immunostimulatory molecule, R837, their surface modified using membranes derived from cells, conferring exceptional specificity for targeting. CFRI demonstrated extraordinary conversion efficiency 49%, adeptly eradicating situ tumors. This process also triggered release damage-associated molecular patterns, thereby activating dendritic cells catalyzing maturation differentiation T initiating robust immune response. vivo animal models substantiated that CFRI-mediated immunotherapeutic markedly suppressed proliferation tumors provoked vigorous systemic response, effectively curtailing metastasis recurrence distant The successful development system offers promising horizon future clinical translations pioneering research oncology.

Язык: Английский

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