Cells,
Год журнала:
2024,
Номер
13(11), С. 908 - 908
Опубликована: Май 24, 2024
The
future
of
drug
delivery
offers
immense
potential
for
the
creation
nanoplatforms
based
on
nanogels.
Nanogels
present
a
significant
possibility
pharmaceutical
advancements
because
their
excellent
stability
and
effective
drug-loading
capability
both
hydrophobic
hydrophilic
agents.
As
multifunctional
systems,
composite
nanogels
demonstrate
capacity
to
carry
genes,
drugs,
diagnostic
agents
while
offering
perfect
platform
theranostic
multimodal
applications.
can
achieve
diverse
responsiveness
enable
stimuli-responsive
release
chemo-/immunotherapy
drugs
thus
reprogramming
cells
within
TME
in
order
inhibit
tumor
proliferation,
progression,
metastasis.
In
active
targeting
boost
accumulation
at
target
sites,
particular
ligands
be
added
improve
therapeutic
outcomes
enhance
precision
cancer
therapy.
Modern
“immune-specific”
also
have
extra
sophisticated
tissue-editing
properties.
Consequently,
introduction
nanogel-based
system
improves
targeted
distribution
immunotherapy
combinational
treatments,
thereby
increasing
effectiveness
Tumor
immunotherapy,
which
utilizes
the
immune
system
to
fight
cancer,
represents
a
revolutionary
method
for
cancer
treatment.
Poly
(lactic-co-glycolic
acid)
(PLGA)
copolymer
has
emerged
as
promising
material
tumor
immunotherapy
due
its
biocompatibility,
biodegradability,
and
versatility
in
drug
delivery.
By
tuning
size,
shape,
surface
properties
of
PLGA-based
systems,
researchers
have
improved
their
ability
align
with
requirements
diverse
modalities.
In
this
review,
basic
PLGA
materials
are
first
introduced
further
principal
forms
systems
controlled
release
summarized
delivery
applications
targeted.
addition,
recent
advances
use
highlighted
enhance
antitumor
responses
terms
vaccines,
immunogenic
cell
death-mediated
responses,
microenvironment
modulation,
combination
immunotherapies.
Finally,
prospects
future
research
clinical
translation
proposed.
With
the
rapid
development
of
nanotechnology,
nanomaterials
have
shown
immense
potential
for
antitumor
applications.
Nanosized
calcium
carbonate
(CaCO3)
materials
exhibit
excellent
biocompatibility
and
degradability,
been
utilized
to
develop
platform
technologies
cancer
therapy.
These
can
be
engineered
carry
anticancer
drugs
functional
groups
that
specifically
target
cells
tissues,
thereby
enhancing
therapeutic
efficacy.
Additionally,
their
physicochemical
properties
tailored
enable
stimuli-responsive
therapy
precision
drug
delivery.
This
Review
consolidates
recent
literatures
focusing
on
synthesis,
properties,
multimodal
therapies
CaCO3-based
nanoplatforms
(CBN).
We
also
explore
current
challenges
breakthroughs
in
CBN
applications,
providing
a
valuable
reference
researchers
field.
ACS Nano,
Год журнала:
2024,
Номер
18(31), С. 20313 - 20323
Опубликована: Июль 24, 2024
The
self-renewal
and
differentiation
properties
of
cancer
stem
cells
(CSCs)
result
in
chemoresistance
breast
cancer.
Even
though
numerous
drugs
have
been
developed
to
target
CSCs,
they
suffered
from
inefficient
delivery
accumulation
at
the
focal
site.
Here,
a
thermoresponsive
hydrogel
is
by
coencapsulating
aggregation-induced
emission
(AIE)-active
photothermal
agent
thioridazine
(THZ),
demonstrating
controllable
system
triggered
AIE
augment
THZ-mediated
CSC
ablation.
Upon
near-infrared
laser
stimuli,
effect
induces
deformation
for
burst
drug
release.
precise
situ
tumor
administration
accelerates
diffusion
deep
lesions.
Thus,
THZ
can
invade
tumors
provoke
massive
apoptosis
via
dopamine
receptor
blockage
oxidative
stress
induction.
Consequently,
effective
inhibition
significant
suppression
recurrence
metastasis
are
demonstrated
mice
with
We
believe
that
this
intelligent
hydrogel-based
represents
promising
treatment
strategy
metastatic
clinical
potential.
Biomaterials Research,
Год журнала:
2024,
Номер
28
Опубликована: Янв. 1, 2024
Cancer
has
become
one
of
the
most
important
factors
threatening
human
health,
and
global
cancer
burden
been
increasing
rapidly.
Immunotherapy
another
clinical
research
hotspot
after
surgery,
chemotherapy,
radiotherapy
because
its
high
efficiency
tumor
metastasis
prevention.
However,
problems
such
as
lower
immune
response
rate
immune-related
adverse
reaction
in
application
immunotherapy
need
to
be
urgently
solved.
With
development
nanodrug
delivery
systems,
various
nanocarrier
materials
have
used
antitumor
with
encouraging
therapeutic
results.
In
this
review,
we
mainly
summarized
combination
systems
from
following
4
aspects:
(a)
combined
cytokine
therapy
improve
cytokines
vivo;
(b)
provided
a
suitable
platform
for
checkpoint
blockade
other
treatments;
(c)
helped
deliver
antigens
adjuvants
vaccines
enhance
effects;
(d)
improved
treatment
reduced
toxicity
adoptive
cell
therapy.
Nanomaterials
chosen
by
researchers
construct
their
function
were
also
introduced
detail.
Finally,
discussed
current
challenges
future
prospects
combining
immunotherapy.
Abstract
The
normal
operation
of
organelles
is
critical
for
tumor
growth
and
metastasis.
Herein,
an
intelligent
nanoplatform
(BMA
EF
)
fabricated
to
perform
on‐demand
destruction
mitochondria
golgi
apparatus,
which
also
generates
the
enhanced
photothermal‐immunotherapy,
resulting
in
effective
inhibition
primary
metastasis
tumor.
BMA
has
a
core
mesoporous
silica
nanoparticles
loaded
with
brefeldin
A
(BM),
connected
ethylenebis(oxyethylenenitrilo)tetraacetic
acid
(EGTA)
folic
co‐modified
gold
(A
).
During
therapy,
first
accumulates
cells
via
acid‐induced
targeting.
Subsequently,
schiff
base/ester
bond
cleaves
lysosome
release
exposed
EGTA.
EGTA
further
captures
Ca
2+
block
ion
transfer
among
mitochondria,
endoplasmic
reticulum,
not
only
induced
dysfunction
apparatus
assisted
by
suppress
both
energy
material
metabolism
against
metastasis,
but
causes
aggregation
tumor‐specific
photothermal
therapy
immunotherapy.
Moreover,
these
stops
production
BMI1
heat
shock
protein
70
enhance
meanwhile
triggers
escape
cytochrome
C
cytoplasm,
leading
additional
apoptosis
cells.
Nanoscale,
Год журнала:
2024,
Номер
16(14), С. 6876 - 6899
Опубликована: Янв. 1, 2024
CaCO
3
nanoparticles
as
nanocarriers
for
drug,
protein,
gene,
and
co-delivery
are
discussed.
Furthermore,
their
combinations
with
other
therapies,
including
photodynamic
therapy,
sonodynamic
immunotherapy,
imaging,
reviewed.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 8, 2024
Head
and
neck
squamous
cell
carcinoma
(HNSCC)
rank
among
the
most
prevalent
types
of
head
cancer
globally.
Unfortunately,
a
significant
number
patients
receive
their
diagnoses
at
advanced
stages,
limiting
effectiveness
available
treatments.
The
tumor
microenvironment
(TME)
is
pivotal
player
in
HNSCC
development,
with
macrophages
holding
central
role.
Macrophages
demonstrate
diverse
functions
within
TME,
both
inhibiting
facilitating
progression.
M1
are
characterized
by
phagocytic
immune
activities,
while
M2
tend
to
promote
inflammation
immunosuppression.
Striking
balance
between
these
different
polarization
states
essential
for
maintaining
overall
health,
yet
context
tumors,
typically
prevail.
Recent
efforts
have
been
directed
controlling
macrophages,
paving
way
novel
approaches
treatment.
Various
drugs
immunotherapies,
including
innovative
treatments
based
on
like
engineering
CAR-M
therapy,
developed.
This
article
provides
an
overview
roles
played
HNSCC,
explores
potential
therapeutic
targets
strategies,
presents
fresh
perspectives
future
Bioconjugate Chemistry,
Год журнала:
2024,
Номер
35(8), С. 1089 - 1115
Опубликована: Июль 11, 2024
Targeted
protein
degradation
or
TPD,
is
rapidly
emerging
as
a
treatment
that
utilizes
small
molecules
to
degrade
proteins
cause
diseases.
TPD
allows
for
the
selective
removal
of
disease-causing
proteins,
including
proteasome-mediated
degradation,
lysosome-mediated
and
autophagy-mediated
degradation.
This
approach
has
shown
great
promise
in
preclinical
studies
now
being
translated
treat
numerous
diseases,
neurodegenerative
infectious
cancer.
review
discusses
latest
advances
its
potential
new
chemical
modality
immunotherapy,
with
special
focus
on
innovative
applications
cutting-edge
research
PROTACs
(Proteolysis
TArgeting
Chimeras)
their
efficient
translation
from
scientific
discovery
technological
achievements.
Our
also
addresses
significant
obstacles
prospects
this
domain,
while
offering
insights
into
future
immunotherapeutic
applications.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 5739 - 5761
Опубликована: Июнь 1, 2024
Proteolysis-targeting
chimeras
(PROTACs)
are
heterobifunctional
molecules
that
have
the
capability
to
induce
specific
protein
degradation.
While
playing
a
revolutionary
role
in
effectively
degrading
of
interest
(POI),
PROTACs
encounter
certain
limitations
impede
their
clinical
translation.
These
encompass
off-target
effects,
inadequate
cell
membrane
permeability,
and
hook
effect.
The
advent
nanotechnology
presents
promising
avenue
surmount
challenges
associated
with
conventional
PROTACs.
utilization
nano-proteolysis
targeting
(nano-PROTACs)
holds
potential
enhance
tissue
accumulation,
augment
enable
controlled
release.
Consequently,
this
approach
has
capacity
significantly
controllable
degradation
target
proteins.
Additionally,
they
synergistic
effect
by
combining
other
therapeutic
strategies.
This
review
comprehensively
summarizes
structural
basis,
advantages,
Furthermore,
it
highlights
latest
advancements
nanosystems
engineered
for
delivering
PROTACs,
as
well
development
nano-sized
employing
nanocarriers
linkers.
Moreover,
delves
into
underlying
principles
tailored
specifically
alongside
current
prospects
research.
In
conclusion,
integration
harbors
vast
enhancing
anti-tumor
treatment
response
expediting
