Hybrid Nanogel Drug Delivery Systems: Transforming the Tumor Microenvironment through Tumor Tissue Editing DOI Creative Commons
Theodora Katopodi, Savvas Petanidis, George Floros

и другие.

Cells, Год журнала: 2024, Номер 13(11), С. 908 - 908

Опубликована: Май 24, 2024

The future of drug delivery offers immense potential for the creation nanoplatforms based on nanogels. Nanogels present a significant possibility pharmaceutical advancements because their excellent stability and effective drug-loading capability both hydrophobic hydrophilic agents. As multifunctional systems, composite nanogels demonstrate capacity to carry genes, drugs, diagnostic agents while offering perfect platform theranostic multimodal applications. can achieve diverse responsiveness enable stimuli-responsive release chemo-/immunotherapy drugs thus reprogramming cells within TME in order inhibit tumor proliferation, progression, metastasis. In active targeting boost accumulation at target sites, particular ligands be added improve therapeutic outcomes enhance precision cancer therapy. Modern “immune-specific” also have extra sophisticated tissue-editing properties. Consequently, introduction nanogel-based system improves targeted distribution immunotherapy combinational treatments, thereby increasing effectiveness

Язык: Английский

Versatile PLGA‐Based Drug Delivery Systems for Tumor Immunotherapy DOI Creative Commons

Yishu Wang,

Xiaoming Hu, Jinghui Wang

и другие.

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Tumor immunotherapy, which utilizes the immune system to fight cancer, represents a revolutionary method for cancer treatment. Poly (lactic-co-glycolic acid) (PLGA) copolymer has emerged as promising material tumor immunotherapy due its biocompatibility, biodegradability, and versatility in drug delivery. By tuning size, shape, surface properties of PLGA-based systems, researchers have improved their ability align with requirements diverse modalities. In this review, basic PLGA materials are first introduced further principal forms systems controlled release summarized delivery applications targeted. addition, recent advances use highlighted enhance antitumor responses terms vaccines, immunogenic cell death-mediated responses, microenvironment modulation, combination immunotherapies. Finally, prospects future research clinical translation proposed.

Язык: Английский

Процитировано

2

Calcium Carbonate-Based Nanoplatforms for Cancer Therapeutics: Current State of Art and Future Breakthroughs DOI Creative Commons
Xiaoting Zhou, Qihui Wang,

Zipeng Lei

и другие.

ACS Omega, Год журнала: 2024, Номер unknown

Опубликована: Март 10, 2024

With the rapid development of nanotechnology, nanomaterials have shown immense potential for antitumor applications. Nanosized calcium carbonate (CaCO3) materials exhibit excellent biocompatibility and degradability, been utilized to develop platform technologies cancer therapy. These can be engineered carry anticancer drugs functional groups that specifically target cells tissues, thereby enhancing therapeutic efficacy. Additionally, their physicochemical properties tailored enable stimuli-responsive therapy precision drug delivery. This Review consolidates recent literatures focusing on synthesis, properties, multimodal therapies CaCO3-based nanoplatforms (CBN). We also explore current challenges breakthroughs in CBN applications, providing a valuable reference researchers field.

Язык: Английский

Процитировано

9

Stimuli-Responsive Hydrogels Potentiating Photothermal Therapy against Cancer Stem Cell–Induced Breast Cancer Metastasis DOI
Tianfu Zhang, Ping Wei,

Meng Suo

и другие.

ACS Nano, Год журнала: 2024, Номер 18(31), С. 20313 - 20323

Опубликована: Июль 24, 2024

The self-renewal and differentiation properties of cancer stem cells (CSCs) result in chemoresistance breast cancer. Even though numerous drugs have been developed to target CSCs, they suffered from inefficient delivery accumulation at the focal site. Here, a thermoresponsive hydrogel is by coencapsulating aggregation-induced emission (AIE)-active photothermal agent thioridazine (THZ), demonstrating controllable system triggered AIE augment THZ-mediated CSC ablation. Upon near-infrared laser stimuli, effect induces deformation for burst drug release. precise situ tumor administration accelerates diffusion deep lesions. Thus, THZ can invade tumors provoke massive apoptosis via dopamine receptor blockage oxidative stress induction. Consequently, effective inhibition significant suppression recurrence metastasis are demonstrated mice with We believe that this intelligent hydrogel-based represents promising treatment strategy metastatic clinical potential.

Язык: Английский

Процитировано

9

Nanodrug Delivery Systems in Antitumor Immunotherapy DOI Creative Commons
Zishuo Guo, Jinhong Ye, Xuehao Cheng

и другие.

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

Cancer has become one of the most important factors threatening human health, and global cancer burden been increasing rapidly. Immunotherapy another clinical research hotspot after surgery, chemotherapy, radiotherapy because its high efficiency tumor metastasis prevention. However, problems such as lower immune response rate immune-related adverse reaction in application immunotherapy need to be urgently solved. With development nanodrug delivery systems, various nanocarrier materials have used antitumor with encouraging therapeutic results. In this review, we mainly summarized combination systems from following 4 aspects: (a) combined cytokine therapy improve cytokines vivo; (b) provided a suitable platform for checkpoint blockade other treatments; (c) helped deliver antigens adjuvants vaccines enhance effects; (d) improved treatment reduced toxicity adoptive cell therapy. Nanomaterials chosen by researchers construct their function were also introduced detail. Finally, discussed current challenges future prospects combining immunotherapy.

Язык: Английский

Процитировано

8

Synergistic Regulation of Targeted Organelles in Tumor Cells to Promote Photothermal‐Immunotherapy Using Intelligent Core‐Satellite‐Like Nanoparticles for Effective Treatment of Breast Cancer DOI
X.-B. Chang,

Xiaoyu Tang,

Wenjun Tang

и другие.

Small, Год журнала: 2024, Номер 20(35)

Опубликована: Апрель 18, 2024

Abstract The normal operation of organelles is critical for tumor growth and metastasis. Herein, an intelligent nanoplatform (BMA EF ) fabricated to perform on‐demand destruction mitochondria golgi apparatus, which also generates the enhanced photothermal‐immunotherapy, resulting in effective inhibition primary metastasis tumor. BMA has a core mesoporous silica nanoparticles loaded with brefeldin A (BM), connected ethylenebis(oxyethylenenitrilo)tetraacetic acid (EGTA) folic co‐modified gold (A ). During therapy, first accumulates cells via acid‐induced targeting. Subsequently, schiff base/ester bond cleaves lysosome release exposed EGTA. EGTA further captures Ca 2+ block ion transfer among mitochondria, endoplasmic reticulum, not only induced dysfunction apparatus assisted by suppress both energy material metabolism against metastasis, but causes aggregation tumor‐specific photothermal therapy immunotherapy. Moreover, these stops production BMI1 heat shock protein 70 enhance meanwhile triggers escape cytochrome C cytoplasm, leading additional apoptosis cells.

Язык: Английский

Процитировано

8

CaCO3 nanoplatform for cancer treatment: drug delivery and combination therapy DOI
Xiaorong Yang,

Yue Sun,

Hong Zhang

и другие.

Nanoscale, Год журнала: 2024, Номер 16(14), С. 6876 - 6899

Опубликована: Янв. 1, 2024

CaCO 3 nanoparticles as nanocarriers for drug, protein, gene, and co-delivery are discussed. Furthermore, their combinations with other therapies, including photodynamic therapy, sonodynamic immunotherapy, imaging, reviewed.

Язык: Английский

Процитировано

7

Macrophages: plastic participants in the diagnosis and treatment of head and neck squamous cell carcinoma DOI Creative Commons
Lin Chen, Yidian Chu, Zheng Ye

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Апрель 8, 2024

Head and neck squamous cell carcinoma (HNSCC) rank among the most prevalent types of head cancer globally. Unfortunately, a significant number patients receive their diagnoses at advanced stages, limiting effectiveness available treatments. The tumor microenvironment (TME) is pivotal player in HNSCC development, with macrophages holding central role. Macrophages demonstrate diverse functions within TME, both inhibiting facilitating progression. M1 are characterized by phagocytic immune activities, while M2 tend to promote inflammation immunosuppression. Striking balance between these different polarization states essential for maintaining overall health, yet context tumors, typically prevail. Recent efforts have been directed controlling macrophages, paving way novel approaches treatment. Various drugs immunotherapies, including innovative treatments based on like engineering CAR-M therapy, developed. This article provides an overview roles played HNSCC, explores potential therapeutic targets strategies, presents fresh perspectives future

Язык: Английский

Процитировано

6

Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions DOI Creative Commons
Rajamanikkam Kamaraj, Subhrojyoti Ghosh,

Souvadra Das

и другие.

Bioconjugate Chemistry, Год журнала: 2024, Номер 35(8), С. 1089 - 1115

Опубликована: Июль 11, 2024

Targeted protein degradation or TPD, is rapidly emerging as a treatment that utilizes small molecules to degrade proteins cause diseases. TPD allows for the selective removal of disease-causing proteins, including proteasome-mediated degradation, lysosome-mediated and autophagy-mediated degradation. This approach has shown great promise in preclinical studies now being translated treat numerous diseases, neurodegenerative infectious cancer. review discusses latest advances its potential new chemical modality immunotherapy, with special focus on innovative applications cutting-edge research PROTACs (Proteolysis TArgeting Chimeras) their efficient translation from scientific discovery technological achievements. Our also addresses significant obstacles prospects this domain, while offering insights into future immunotherapeutic applications.

Язык: Английский

Процитировано

6

Potential of the nanoplatform and PROTAC interface to achieve targeted protein degradation through the Ubiquitin–Proteasome system DOI

Hanshu Xie,

Chao Zhang

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 267, С. 116168 - 116168

Опубликована: Фев. 1, 2024

Язык: Английский

Процитировано

5

Nano-Proteolysis Targeting Chimeras (Nano-PROTACs) in Cancer Therapy DOI Creative Commons
Yue Song,

Qing‐Qing Dong,

Yi-Ke Ni

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 5739 - 5761

Опубликована: Июнь 1, 2024

Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that have the capability to induce specific protein degradation. While playing a revolutionary role in effectively degrading of interest (POI), PROTACs encounter certain limitations impede their clinical translation. These encompass off-target effects, inadequate cell membrane permeability, and hook effect. The advent nanotechnology presents promising avenue surmount challenges associated with conventional PROTACs. utilization nano-proteolysis targeting (nano-PROTACs) holds potential enhance tissue accumulation, augment enable controlled release. Consequently, this approach has capacity significantly controllable degradation target proteins. Additionally, they synergistic effect by combining other therapeutic strategies. This review comprehensively summarizes structural basis, advantages, Furthermore, it highlights latest advancements nanosystems engineered for delivering PROTACs, as well development nano-sized employing nanocarriers linkers. Moreover, delves into underlying principles tailored specifically alongside current prospects research. In conclusion, integration harbors vast enhancing anti-tumor treatment response expediting

Язык: Английский

Процитировано

5