A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing

Journal of Controlled Release, Год журнала: 2024, Номер 368, С. 740 - 755

Опубликована: Март 19, 2024

Язык: Английский

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Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis

Theranostics, Год журнала: 2024, Номер 14(10), С. 4014 - 4057

Опубликована: Янв. 1, 2024

Background:The comprehensive management of diabetic bone defects remains a substantial clinical challenge due to the hostile regenerative microenvironment characterized by aggravated inflammation, excessive reactive oxygen species (ROS), bacterial infection, impaired angiogenesis, and unbalanced homeostasis.Thus, an advanced multifunctional therapeutic platform capable simultaneously achieving immune regulation, elimination, tissue regeneration is urgently designed for augmented under pathological milieu.Methods Results: Herein, photoactivated soft-hard combined scaffold system (PGCZ) was engineered introducing polydopamine-modified zeolitic imidazolate framework-8-loaded double-network hydrogel (soft matrix component) into 3D-printed poly(ε-caprolactone) (PCL) (hard component).The versatile PGCZ based on PCL thus prepared features highly extracellular matrix-mimicking microstructure, suitable biodegradability mechanical properties, excellent photothermal performance, allowing long-term structural stability support regeneration.Under periodic near-infrared (NIR) irradiation, localized effect triggers on-demand release Zn 2+ , which, together with repeated mild hyperthermia, collectively accelerates proliferation osteogenic differentiation preosteoblasts potently inhibits growth biofilm formation.Additionally, also presents outstanding immunomodulatory ROS scavenging capacities, which regulate M2 polarization macrophages drive functional cytokine secretion, leading pro-regenerative in situ enhanced vascularization.In vivo experiments further demonstrated that conjunction activity remarkably attenuated local inflammatory cascade, initiated endogenous stem cell recruitment neovascularization, orchestrated osteoblast/osteoclast balance, ultimately accelerating regeneration. Ivyspring

Язык: Английский

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Recent advances of hydrogels as smart dressings for diabetic wounds

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(5), С. 1126 - 1148

Опубликована: Янв. 1, 2024

This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy diabetic wounds.

Язык: Английский

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Magnesium promotes vascularization and osseointegration in diabetic states

International Journal of Oral Science, Год журнала: 2024, Номер 16(1)

Опубликована: Янв. 31, 2024

Diabetes has long been considered a risk factor in implant therapy and impaired wound healing soft hard oral tissues. Magnesium proved to promote bone under normal conditions. Here, we elucidate the mechanism by which Mg

Язык: Английский

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Microenvironment-responsive smart hydrogels with antibacterial activity and immune regulation for accelerating chronic wound healing

Journal of Controlled Release, Год журнала: 2024, Номер 368, С. 518 - 532

Опубликована: Март 12, 2024

Язык: Английский

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