Theranostics, Год журнала: 2025, Номер 15(11), С. 5172 - 5219
Опубликована: Апрель 9, 2025
Язык: Английский
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Май 9, 2024
Abstract Background Dry Eye Disease (DED) is a prevalent multifactorial ocular disease characterized by vicious cycle of inflammation, oxidative stress, and mitochondrial dysfunction on the surface, all which lead to DED deterioration impair patients’ quality life social functioning. Currently, anti-inflammatory drugs have shown promising efficacy in treating DED; however, such are associated with side effects. The bioavailability less than 5% owing factors as rapid tear turnover presence corneal barrier. This calls for investigations overcome these challenges drug administration. Results A novel hierarchical action liposome nanosystem (PHP-DPS@INS) was developed this study. In terms delivery, PHP-DPS@INS nanoparticles (NPs) overcame surface transport barrier adopting strategy “ocular electrostatic adhesion-lysosomal site-directed escape”. therapy, achieved targeting antioxidant effects through SS-31 peptide, exerted an effect loading insulin reduce inflammatory metabolites. Ultimately, synergistic “anti-inflammation-antioxidation-mitochondrial function restoration” breaks DED. demonstrated remarkable cellular uptake, lysosomal escape, vitro. Targeted metabolomics analysis revealed that effectively normalized elevated level proinflammatory metabolite fumarate vitro hypertonic model DED, thereby reducing levels key (IL-1β, IL-6, TNF-α). Additionally, strongly inhibited reactive oxygen species (ROS) production facilitated structural repair. vivo, treatment significantly enhanced adhesion duration permeability mice, improving bioavailability. It also restored secretion, suppressed damage, reduced inflammation mice. Moreover, it favorable safety profiles both vivo. Conclusion summary, study successfully comprehensive management transmission disrupted dry eye pathogenesis. pioneered regulation metabolites conditions, presenting safe, efficient, innovative therapeutic other diseases.
Язык: Английский
Процитировано
8
Bioactive Materials, Год журнала: 2024, Номер 37, С. 94 - 105
Опубликована: Март 16, 2024
The vulnerable plaques in atherosclerosis can cause severe outcome with great danger of acute cardiovascular events. Thus, timely diagnosis and treatment early stage effectively benefit the clinical management atherosclerosis. In this work, a targeting theranostic strategy on early-stage is realized by LAID nanoplatform X-CT fluorescent dual-mode imaging lipid-inflammation integrated regulation abilities. iodinated contrast agents (ICA), phenylboronic acid modified astaxanthin oxidized-dextran (oxDEX) jointly construct nanoparticles loaded lipid-specific probe LFP. indicates an active to along dual-responsive disassembly oxidative stress acidic microenvironment signals ICA execute location plaques, while LFP combines lipid cores realizes recognition plaques. Meanwhile, based performed for restraining progression Transcriptome sequencing suggests that inhibit uptake block NF-κB pathway, which synergistically demonstrates suppression growing.
Язык: Английский
Процитировано
6
Biomaterials Science, Год журнала: 2024, Номер 12(15), С. 3805 - 3825
Опубликована: Янв. 1, 2024
Stimuli-responsive polymer-based nanosystems have gained significant attention for cardiovascular disease theranostics. This review summarizes various stimuli-responsive used diagnosing and treating diseases.
Язык: Английский
Процитировано
6
ACS Nano, Год журнала: 2024, Номер unknown
Опубликована: Фев. 6, 2024
Given the multifactorial pathogenesis of atherosclerosis (AS), a chronic inflammatory disease, combination therapy arises as compelling approach to effectively address complex interplay pathogenic mechanisms for more desired treatment outcome. Here, we present
Язык: Английский
Процитировано
5
Chemical Science, Год журнала: 2024, Номер 15(20), С. 7524 - 7544
Опубликована: Янв. 1, 2024
The preparation of right-side-out-orientated coupling-driven ROS-sensitive nanoparticles on the inner leaflet cell membrane for positively regulating phenotypic conversion in atherosclerosis.
Язык: Английский
Процитировано
5
Medicine in Drug Discovery, Год журнала: 2024, Номер 22, С. 100189 - 100189
Опубликована: Апрель 5, 2024
Atherosclerosis, a highly prevalent cardiovascular disease, has significantly contributed to morbidity and mortality worldwide. Despite the availability of various treatment options in clinical practice, complete reversal atherosclerotic pathological process remains challenging. Traditional anti-arteriosclerosis drugs often suffer from poor solubility, limited targeting ability obvious adverse effects. Additionally, novel therapeutics such as genetic protein-based inherently instability issues, thereby compromising their actual curative efficacy impeding further application. Recently, nanomedicine-based drug delivery strategies have emerged promising approaches for treating atherosclerosis due specifically transport target cells, microstructures specific molecules within lesion sites. These advanced features enhance properties bioavailability while minimizing off-target Moreover, numerous studies demonstrated that nanomedicine not only inhibits plaque progression but also reduces lesional areas eventually reverses atherosclerosis. The utilization is considered an important therapeutic tactic mitigating residual risks associated with This review provides comprehensive overview emerging targeted anti-atherosclerosis drugs, elucidating distinct mechanisms highlighting remarkable combating critical challenges future perspectives development application are thoroughly discussed.
Язык: Английский
Процитировано
5
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(40), С. 47381 - 47393
Опубликована: Сен. 28, 2023
The formation of atherosclerosis is the root cause various cardiovascular diseases (CVDs). Therefore, effective CVD interventions call for precise identification plaques to aid in clinical treatment such diseases. Herein, a reactive oxygen species (ROS)-responsive sequentially targeted fluorescent probe developed atherosclerotic plaque recognition. An aggregation-induced emission active fluorophore linked maleimide (polyethylene glycol) hydroxyl with ROS-responsive cleavable bond, which further functionalized CLIKKPF peptide (TPAMCF) specifically binding phosphatidylserine foam cells. After being assembled aqueous medium, TPAMCF nanoparticles can efficiently accumulate through high affinity externalized Activated by locally accumulated ROS cells, are interrupted, and then TPA be released subsequently identify lipid droplets inside cells achieve fluorescence imaging plaques. Such nanoprobes have favorable response performance exhibit special target vitro. In addition, nanoprobe-based permitted high-contrast detection specimens ex vivo. as promising probe, capable potential candidate plaque.
Язык: Английский
Процитировано
12
Regenerative Biomaterials, Год журнала: 2023, Номер 11
Опубликована: Ноя. 21, 2023
Abstract Metal ions participate in many metabolic processes the human body, and their homeostasis is crucial for life. In cardiovascular diseases (CVDs), equilibriums of metal are frequently interrupted, which related to a variety disturbances physiological leading abnormal cardiac functions. Exogenous supplement has potential work as therapeutic strategies treatment CVDs. Compared with other drugs, possess broad availability, good stability safety diverse drug delivery strategies. The important exert effects reduce toxic side applications, also receiving increasing attention. Controllable local based on various biomaterials constantly being designed. this review, we comprehensively summarized positive roles CVDs from three aspects: protecting cells oxidative stress, inducing angiogenesis, adjusting functions ion channels. addition, introduced transferability vascular reconstruction tissue repair, well currently available engineered precise ions, such integrated nanoparticles, hydrogels scaffolds.
Язык: Английский
Процитировано
12
ACS Nano, Год журнала: 2024, Номер unknown
Опубликована: Июль 17, 2024
Neovascular age-related macular degeneration (AMD), a leading cause of blindness, requires frequent intravitreal injection antivascular endothelial growth factor (anti-VEGF), which could generate succession complications with poor patient compliance. The current VEGF-targeting therapies often fail in half patients due to the complex pathologic microenvironment excessive reactive oxygen species (ROS) production, and increased levels inflammation are accompanied by choroidal neovascularization (CNV). We herein reported multifunctional nanotherapeutics featuring superior antioxidant anti-inflammation properties that aim reverse pathological condition, alongside its strong targeted antiangiogenesis CNV ability provide long-term sustained bioactive delivery via minimally invasive subconjunctival injection, so as achieve satisfactory wet AMD treatment effects. Concretely, nanomedicine was designed coencapsulation astaxanthin (AST), red pigmented carotenoid known for antioxidative, anti-inflammatory antiapoptotic properties, axitinib (AXI), small molecule tyrosine kinase inhibitor selectively targets vascular epidermal receptor antiangiogenesis, into Food Drug Administration (FDA) approved poly(lactic-co-glycolic acid) (PLGA), forms nanodrug PLGA@AST/AXI. Our results demonstrated single-dose administration PLGA@AST/AXI showed rational synergistic effect targeting various prevailing risk factors associated AMD, ensuring persistent drug release profiles, maintaining good ocular biocompatibility, causing no obvious mechanical damage. Such attributes vital hold significant potential treating posterior segment diseases. Moreover, this nanotherapeutic strategy represents versatile broad-spectrum nanoplatform, offering promising alternative progression other neovascular
Язык: Английский
Процитировано
4
ACS Sensors, Год журнала: 2024, Номер 9(9), С. 4898 - 4905
Опубликована: Сен. 5, 2024
Copper ions, implicated in processes such as oxidative stress and inflammation, are believed to play a crucial role cardiovascular disease, prevalent deadly disease. Despite this, current diagnostic methods fail detect early stage disease or track copper ion accumulation, limiting our understanding of the disease's progression. Therefore, development noninvasive techniques image ions is urgently needed enhance precision therapeutic strategies. In this study, we report successful synthesis application ion-activated photoacoustic probe,
Язык: Английский
Процитировано
4