Inorganics,
Год журнала:
2025,
Номер
13(3), С. 71 - 71
Опубликована: Фев. 26, 2025
As
a
non-invasive
modality,
sonodynamic
therapy
(SDT)
offers
several
advantages
in
cancer
treatment,
including
deep
tissue
penetration
and
precise
spatiotemporal
control,
resulting
from
the
interplay
between
low-intensity
ultrasound
sonosensitizers.
Piezoelectric
materials,
known
for
their
remarkable
capacity
of
interconversion
mechanical
electrical
energy,
have
garnered
considerable
attention
biomedical
applications,
which
can
serve
as
pivotal
sonosensitizers
SDT.
These
materials
generate
internal
electric
fields
via
ultrasound-induced
deformation,
modulates
alteration
charge
carriers,
thereby
initiating
surface
redox
reactions
to
reactive
oxygen
species
(ROS)
realizing
therapeutic
efficacy
This
review
provides
an
in-depth
exploration
piezoelectric
utilized
SDT,
with
particular
emphasis
on
recent
innovations,
elucidation
underlying
mechanisms,
optimization
strategies
advanced
materials.
Furthermore,
incorporation
immunotherapy,
photodynamic,
chemodynamic,
chemotherapy
is
explored,
emphasizing
potential
enhance
outcomes.
By
examining
basic
principles
effect
its
contributions
this
sheds
light
promising
applications
oncology.
It
also
highlights
future
directions
improving
these
expanding
clinical
utility
tumor
therapy.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 30, 2025
Abstract
Traditional
biomaterial
development
lacks
systematicity
and
predictability,
posing
significant
challenges
in
addressing
the
intricate
engineering
issues
related
to
infections
with
drug‐resistant
bacteria.
The
unprecedented
ability
of
artificial
intelligence
(AI)
manage
complex
systems
offers
a
novel
paradigm
for
materials
development.
However,
no
AI
model
currently
guides
antibacterial
biomaterials
based
on
an
in‐depth
understanding
interplay
between
In
this
study,
AI‐guided
design
platform
(AMP‐hydrogel‐Designer)
is
developed
generate
biomaterials.
This
utilizes
generative
multi‐objective
constrained
optimization
thiol‐containing
high‐efficiency
antimicrobial
peptide
(AMP),
that
functionally
coupled
hydrogel
form
network
structure.
Additionally,
Cu‐modified
barium
titanate
(Cu‐BTO)
incorporated
facilitate
further
cross–linking
via
Cu
2+
/SH
coordination
produce
AI‐AMP‐hydrogel.
vitro,
AI‐AMP‐hydrogel
exhibits
>
99.99%
bactericidal
efficacy
against
Methicillin‐resistant
Staphylococcus
aureus
(MRSA)
Escherichia
coli
(
E.
coli)
.
Furthermore,
Cu‐BTO
converts
mechanical
stimulation
into
electrical
signals,
thereby
promoting
expression
growth
factors
angiogenesis.
rat
dynamic
wounds,
AI‐AMP
significantly
reduces
MRSA
load
markedly
accelerates
wound
healing.
Therefore,
strategy
innovative
solution
precisely
treat
bacterial
infections.
Nanoscale,
Год журнала:
2024,
Номер
16(18), С. 8708 - 8738
Опубликована: Янв. 1, 2024
Cancer
immunotherapy,
a
burgeoning
modality
for
cancer
treatment,
operates
by
activating
the
autoimmune
system
to
impede
growth
of
malignant
cells.
Although
numerous
immunotherapy
strategies
have
been
employed
in
clinical
therapy,
resistance
cells
immunotherapeutic
medications
and
other
apprehensions
attainment
sustained
advantages
most
patients.
Recent
advancements
nanotechnology
drug
delivery
hold
promise
augmenting
efficacy
immunotherapy.
However,
is
currently
constrained
inadequate
specificity
delivery,
low
rate
response,
intricate
immunosuppressive
tumor
microenvironment.
In
this
context,
investigation
cell
membrane
coated
nanoparticles
(CMNPs)
has
revealed
their
ability
perform
targeted
immune
evasion,
controlled
release,
immunomodulation.
By
combining
advantageous
features
natural
membranes
nanoparticles,
CMNPs
demonstrated
unique
potential
realm
This
review
aims
emphasize
recent
research
progress
elucidate
underlying
mechanisms
as
an
innovative
platform
enhancing
Additionally,
it
provides
comprehensive
overview
current
involving
different
types
CMNPs,
with
intention
further
exploration
optimization.
ABSTRACT
Although
drug
delivery
technology
has
promoted
the
clinical
translation
of
small
molecule
drugs,
there
is
an
urgent
need
for
advanced
systems
to
overcome
complex
physiological
barriers
and
increasing
development
biological
drugs.
This
review
overviews
emerging
applications
synthetic
biology‐based
engineered
cells
delivery.
We
first
introduce
biology
strategies
engineer
discuss
benefits
in
terms
specificity,
intelligence,
controllability.
Furthermore,
we
highlight
cutting‐edge
advancements
at
convergence
nanotechnology
Nanotechnology
expands
engineering
design
construction
concepts
biology,
drives
biotechnology‐driven
nanomaterial
synthesis.
In
future,
may
be
developed
more
modular,
standardized,
intelligent,
leading
significant
breakthroughs
systems.
