Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
Chemical
reactions
underpin
biological
processes,
and
imbalances
in
critical
biochemical
pathways
within
organisms
can
lead
to
the
onset
of
severe
diseases.
Within
this
context,
emerging
field
“Nanocatalytic
Medicine”
leverages
nanomaterials
as
catalysts
modulate
fundamental
chemical
specific
microenvironments
This
approach
is
designed
facilitate
targeted
synthesis
localized
accumulation
therapeutic
agents,
thus
enhancing
treatment
efficacy
precision
while
simultaneously
reducing
systemic
side
effects.
The
effectiveness
these
nanocatalytic
strategies
critically
hinges
on
a
profound
understanding
kinetics
intricate
interplay
particular
pathological
ensure
effective
catalytic
actions.
review
methodically
explores
situ
their
associated
biomaterials,
emphasizing
regulatory
that
control
responses.
Furthermore,
discussion
encapsulates
crucial
elements‐reactants,
catalysts,
reaction
conditions/environments‐necessary
for
optimizing
thermodynamics
reactions,
rigorously
addressing
both
biophysical
dimensions
disease
enhance
outcomes.
It
seeks
clarify
mechanisms
underpinning
biomaterials
evaluate
potential
revolutionize
across
various
conditions.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(7)
Опубликована: Ноя. 2, 2023
Abstract
Cancer
immunotherapy
holds
great
promise
but
is
generally
limited
by
insufficient
induction
of
anticancer
immune
responses.
In
this
work,
Microcystis
aerugiosa
(MA)
observed
to
act
as
an
stimulator,
which
activates
the
cGAS‐STING
and
IRF‐signaling
pathways
dendritic
cells
(DCs),
induces
immunostimulatory
factors
production,
eventually
resulting
in
death
tumor
promoting
cytotoxic
CD8
+
T
infiltration.
To
further
enhance
immunogenicity,
MA
engineered
with
polydopamine
(PDA)
assembled
injectable
Pluronic
F127
hydrogels
(denoted
MA@PDA‐F127).
The
introduction
PDA
endows
MA@PDA‐F127
photothermal
therapy
capability,
enhances
immunogenicity
situ
exposing
damage‐associated
molecular
patterns
antigens
from
dying
cells.
Importantly,
surface‐rich
reaction
sites
thermosensitive
capture
antigens,
facilitating
long
retention
exposure
enhancing
DCs
maturation
for
advanced
anti‐tumor
response.
Accordingly,
administration
a
single
dose
achieves
efficient
eradication
both
primary
distant
tumors
orthotopic
metastasis
model.
Furthermore,
hydrogel
can
sensitize
checkpoint
inhibitor
cell
infiltration
murine
Collectively,
offers
effective
therapeutic
augmenting
activating
systematic
Nanoscale,
Год журнала:
2023,
Номер
15(48), С. 19407 - 19422
Опубликована: Янв. 1, 2023
Sonocatalytic
cancer
therapy
has
emerged
as
a
promising
strategy
through
the
combination
of
ultrasound
waves
and
catalytic
materials
to
selectively
target
destroy
cells.
Nanomaterials,
Год журнала:
2024,
Номер
14(9), С. 797 - 797
Опубликована: Май 3, 2024
Nanomaterials,
with
unique
physical,
chemical,
and
biocompatible
properties,
have
attracted
significant
attention
as
an
emerging
active
platform
in
cancer
diagnosis
treatment.
Amongst
them,
metal–organic
framework
(MOF)
nanostructures
are
particularly
promising
a
nanomedicine
due
to
their
exceptional
surface
functionalities,
adsorption
organo-inorganic
hybrid
characteristics.
Furthermore,
when
bioactive
substances
integrated
into
the
structure
of
MOFs,
these
materials
can
be
used
anti-tumor
agents
superior
performance
compared
traditional
nanomaterials.
In
this
review,
we
highlight
most
recent
advances
MOFs-based
for
tumor
therapy,
including
application
treatment
underlying
mechanisms.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
Chemical
reactions
underpin
biological
processes,
and
imbalances
in
critical
biochemical
pathways
within
organisms
can
lead
to
the
onset
of
severe
diseases.
Within
this
context,
emerging
field
“Nanocatalytic
Medicine”
leverages
nanomaterials
as
catalysts
modulate
fundamental
chemical
specific
microenvironments
This
approach
is
designed
facilitate
targeted
synthesis
localized
accumulation
therapeutic
agents,
thus
enhancing
treatment
efficacy
precision
while
simultaneously
reducing
systemic
side
effects.
The
effectiveness
these
nanocatalytic
strategies
critically
hinges
on
a
profound
understanding
kinetics
intricate
interplay
particular
pathological
ensure
effective
catalytic
actions.
review
methodically
explores
situ
their
associated
biomaterials,
emphasizing
regulatory
that
control
responses.
Furthermore,
discussion
encapsulates
crucial
elements‐reactants,
catalysts,
reaction
conditions/environments‐necessary
for
optimizing
thermodynamics
reactions,
rigorously
addressing
both
biophysical
dimensions
disease
enhance
outcomes.
It
seeks
clarify
mechanisms
underpinning
biomaterials
evaluate
potential
revolutionize
across
various
conditions.
