In situ engineered magnesium alloy implant for preventing postsurgical tumor recurrence

Bioactive Materials, Год журнала: 2024, Номер 40, С. 474 - 483

Опубликована: Июнь 26, 2024

Invasive tumors are difficult to be completely resected in clinical surgery due the lack of clear resection margins, which greatly increases risk postoperative recurrence. However, chemotherapy and radiotherapy as traditional means adjuvant therapy, limited applications, such multi-drug resistance low sensitivity, etc. Therefore, an engineered magnesium alloy rod is designed a implant remove residual tumor tissue inhibit recurrence by gas mild magnetic hyperthermia therapy (MMHT). As reactive metal, responds acidic microenvironment continuously generating hydrogen. The in-situ generation hydrogen not only protects surrounding normal tissue, but also enables achieve MMHT under low-intensity alternating field (AMF). Furthermore, numerous oxygen species (ROS) produced heat stress will combine with nitric oxide (NO) generated situ, produce more toxic nitrogen (RNS) storm. In summary, can RNS storm AMF, biodegradability makes great potential for application.

Язык: Английский

---

Recent advances in biomaterials based near-infrared mild photothermal therapy for biomedical application: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134746 - 134746

Опубликована: Авг. 13, 2024

Язык: Английский

---

NIR‐Triggered Cu₂O/Cu_2‐xS Heterostructure as an “All‐In‐One” Functional Nanoplatform for Efficient Synergistic Tumor Therapy

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

Abstract The fabrication of synergistic multifunctional anti‐tumor nanoplatforms is challenging due to the urgent requirement activate different therapeutic modalities. Although multi‐modal treatments can be achieved by carrying out activation with exogenous and endogenous stimulations in sequence, this tedious manner not applicable ideal cancer treatment. Herein, a simple heterojunction Cu 2 O/Cu 2‐x S modified gambogic acid hyaluronic (CCS@GA@HA) ingeniously fabricated for treatment combining photothermal therapy (PTT), photocatalytic (PCT), chemodynamic (CDT) potential ferroptosis just activated single near infrared (NIR) light irradiation. heterostructure (CCS) promoted separation transfer efficiency photogenerated charge carriers exhibits excellent performance. intervention (GA) downregulates overexpression heat shock protein 90 (HSP90), which make it possible execute mild PTT. And CDT performance efficiently improved generated from Specifically, CCS appears accelerate accumulation lipid peroxides (LPO) inactivate glutathione peroxidase 4 (GPX4) that directly induce ferroptosis. In brief, CCS@GA@HA prominent NIR‐triggered effect involving PCT, PTT, enhanced an effective tumor

Язык: Английский

---

Metal-based nanocomposites for immunotherapy of osteosarcoma

Advanced Composites and Hybrid Materials, Год журнала: 2024, Номер 7(6)

Опубликована: Окт. 23, 2024

Язык: Английский

---

NIR-Triggered Programmable Nanomotor with H2S and NO Generation for Cascading Oncotherapy by Three-Pronged Reinforcing ICD

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101540 - 101540

Опубликована: Фев. 3, 2025

Язык: Английский

---