ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 12, 2024
The
sophisticated
environment
of
chronic
wounds,
characterized
by
prolonged
exudation
and
recurrent
bacterial
infections,
poses
significant
challenges
to
wound
recovery.
Recent
advancements
in
multifunctional
dressings
fall
short
providing
comprehensive,
accurate,
comfortable
treatment.
To
address
these
issues,
a
battery-free
microfluidic
Janus
dressing
(MM-JWD)
capable
three
functions,
including
exudate
management,
antibacterial
properties,
multiple
indications
infection
detection,
has
been
developed.
During
the
treatment,
fully
soft
membrane
not
only
demonstrated
stable
unidirectional
fluid
transport
capabilities
under
various
skin
deformations
for
longer
period
but
also
provided
effects
through
surface
treatment
with
chitosan
quaternary
ammonium
salts
poly(vinyl
alcohol).
Furthermore,
integrating
colorimetric
sensors
within
membrane's
microchannels
dual-layer
structure
enabled
simultaneous
monitoring
wound's
pH,
uric
acid,
temperature.
was
facilitated
smartphone
recognition
color
changes
sensors.
In
vivo
vitro
tests
confirmed
antibacterial,
sensing
MM-JWD,
proving
its
efficacy
promoting
healing
wounds.
Overall,
this
study
provides
valuable
method
design
care.
RSC Advances,
Год журнала:
2024,
Номер
14(5), С. 3359 - 3378
Опубликована: Янв. 1, 2024
Electrostatic
spinning
as
a
technique
for
producing
nanoscale
fibers
has
recently
attracted
increasing
attention
due
to
its
simplicity,
versatility,
and
loadability.
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101093 - 101093
Опубликована: Май 18, 2024
The
incidence
of
chronic
wound
healing
is
promoted
by
the
growing
trend
elderly
population,
obesity,
and
type
II
diabetes.
Although
numerous
dressings
have
been
studied
over
years,
it
still
challenging
for
many
to
perfectly
adapt
process
due
dynamic
complicated
microenvironment.
Aiming
at
an
optimal
reproduction
physiological
environment,
multifunctional
electrospinning
nanofibrous
membranes
(ENMs)
emerged
as
a
promising
platform
treatment
owing
their
resemblance
extracellular
matrix
(ECM),
adjustable
preparation
processes,
porousness,
good
conformability
site.
Moreover,
profiting
from
booming
development
human-machine
interaction
artificial
intelligence,
next
generation
intelligent
(iENMs)
based
dressing
substrates
that
could
realize
real-time
monitoring
proceeding
individual-based
therapy
has
evoked
surge
interest.
In
this
regard,
general
wound-related
biomarkers
are
overviewed
firstly
representative
iENMs
stimuli-responsive
materials
briefly
summarized.
Subsequently,
emergent
applications
highlighted.
Finally,
opportunities
challenges
next-generation
well
translating
into
clinical
practice
evaluated.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(33), С. 8007 - 8032
Опубликована: Янв. 1, 2024
Inflammatory
skin
diseases,
such
as
psoriasis
and
atopic
dermatitis,
pose
significant
health
challenges
due
to
their
long-lasting
nature,
potential
for
serious
complications,
risks,
which
requires
treatments
that
are
both
effective
exhibit
minimal
side
effects.
Hydrogels
offer
an
innovative
solution
biocompatibility,
tunability,
controlled
drug
delivery
capabilities,
enhanced
treatment
adherence
minimized
effects
risk.
This
review
explores
the
mechanisms
guide
design
of
hydrogel
therapeutic
platforms
from
multiple
perspectives,
focusing
on
components
hydrogels,
adjustable
physical
chemical
properties,
interactions
with
cells
drugs
underscore
clinical
potential.
We
also
examine
various
agents
dermatitis
can
be
integrated
into
including
traditional
drugs,
novel
compounds
targeting
oxidative
stress,
small
molecule
biologics,
emerging
therapies,
offering
insights
advantages.
Additionally,
we
trial
data
evaluate
effectiveness
safety
hydrogel-based
in
managing
under
complex
disease
conditions.
Lastly,
discuss
current
future
opportunities
therapeutics
treating
improving
barrier
penetration
developing
multifunctional
highlight
enhance
long-term
stability.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 13, 2024
Abstract
Current
skin
sensors
or
wound
dressings
fall
short
in
addressing
the
complexities
and
challenges
encountered
real‐world
scenarios,
lacking
adequate
capability
to
facilitate
repair.
The
advancement
of
methodologies
enabling
early
diagnosis,
real‐time
monitoring,
active
regulation
drug
delivery
for
timely
comprehensive
treatment
holds
paramount
significance
complex
chronic
wounds.
In
this
study,
a
nanocomposite
hydrogel
is
devised
monitoring
condition
treatment.
Tannins
siRNA
containing
matrix
metalloproteinase‐9
gene
interference
are
self‐assembled
construct
degradable
nanogel
modified
with
bovine
serum
albumin.
pH
indicator
encapsulated
within
dual‐crosslinking
synthesized
norbornene
dianhydride‐modified
paramylon.
exhibited
excellent
shape
adaptability
due
borate
bonding,
click
polymerization
reaction
led
rapid
situ
curing
hydrogel.
system
not
only
monitors
pH,
temperature,
exudate
alterations,
peristalsis
during
healing
but
also
exhibits
hemostatic,
antimicrobial,
anti‐inflammatory,
antioxidant
properties,
modulates
macrophage
polarization,
facilitates
vascular
tissue
regeneration.
This
therapeutic
approach,
which
integrates
pathological
parameters
treatment,
anticipated
address
clinical
issues
associated
diabetic
wounds
infected
wounds,
offering
broad
prospects
application.
Biomimetics,
Год журнала:
2024,
Номер
9(5), С. 278 - 278
Опубликована: Май 7, 2024
Biomimetic
materials
have
become
a
promising
alternative
in
the
field
of
tissue
engineering
and
regenerative
medicine
to
address
critical
challenges
wound
healing
skin
regeneration.
Skin-mimetic
enormous
potential
improve
outcomes
enable
innovative
diagnostic
sensor
applications.
Human
skin,
with
its
complex
structure
diverse
functions,
serves
as
an
excellent
model
for
designing
biomaterials.
Creating
effective
coverings
requires
mimicking
unique
extracellular
matrix
composition,
mechanical
properties,
biochemical
cues.
Additionally,
integrating
electronic
functionality
into
these
presents
exciting
possibilities
real-time
monitoring,
diagnostics,
personalized
healthcare.
This
review
examines
biomimetic
their
role
healing,
well
integration
technologies.
It
discusses
recent
advances,
challenges,
future
directions
this
rapidly
evolving
field.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(35), С. 8577 - 8604
Опубликована: Янв. 1, 2024
Biosensors
integrated
into
closed-loop
systems
provide
patient-specific
adaptive
therapies.
These
advanced
devices
have
significant
potential
for
managing
chronic
conditions
by
continuously
adjusting
therapeutic
regimens
based
on
physiological
data.
