Scientia Sinica Chimica, Год журнала: 2024, Номер 54(10), С. 1644 - 1662
Опубликована: Июль 16, 2024
Nano-Micro Letters, Год журнала: 2025, Номер 17(1)
Опубликована: Янв. 15, 2025
Abstract The proliferation of wearable biodevices has boosted the development soft, innovative, and multifunctional materials for human health monitoring. integration sensors with intelligent systems is an overwhelming tendency, providing powerful tools remote monitoring personal management. Among many candidates, two-dimensional (2D) stand out due to several exotic mechanical, electrical, optical, chemical properties that can be efficiently integrated into atomic-thin films. While previous reviews on 2D primarily focus conventional configurations like graphene, rapid new opened up novel applications, particularly in smart interaction functionalities. This review aims consolidate recent progress, highlight unique advantages materials, guide future research by discussing existing challenges opportunities applying biodevices. We begin in-depth analysis advantages, sensing mechanisms, potential applications biodevice fabrication. Following this, we systematically discuss state-of-the-art based various physiological signals within body. Special attention given showcasing multi-functionality devices, mainly including self-power supply, diagnosis/treatment, human–machine interaction. Finally, concludes a concise summary prospective solutions concerning utilization advanced
Язык: Английский
Процитировано
7
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Июль 2, 2024
Abstract Recent advances are achieved in the design and development of efficient organic photosensitizers (PSs), especially with fluorescence imaging navigation second near‐infrared (NIR‐II, 1000–1700 nm) region. However, there simply a handful NIR‐II emissive PSs oxygen‐independent capability due to scarcity high‐performance NIR‐responsive materials targeted delivery. Herein, NIR‐II‐emissive nanomedicine biomimetic engineering for multiple phototherapies pancreatic tumors is reported. An A‐D‐A‐type conjugated small‐molecule TPC designed used prepare water‐dispersive nanoparticles, which demonstrated high efficiency type I II photodynamic performances, good photothermal conversion 57%, bright emission quantum yield 9.8% under 808 nm light irradiation. With cancer cell membrane camouflage, high‐resolution bioimaging whole‐body blood vessels tumors. Antitumor experiments tumor elimination biosafety This work versatile enhanced tumor‐targeting superior phototheranostics, providing feasible idea evolution theranostics.
Язык: Английский
Процитировано
7
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(36), С. 25383 - 25393
Опубликована: Авг. 28, 2024
The regulation of the cell membrane potential plays a crucial role in governing transmembrane transport various ions and cellular life processes. However, situ on-demand modulation for ion channel is challenging. Herein, we have constructed supramolecular assembly system based on water-soluble cationic oligo(phenylenevinylene) (OPV) cucurbit[7]uril (CB[7]). controllable disassembly OPV/4CB[7] combined with subsequent click reaction provides step-by-step adjustable surface positive potential. These processes can be employed plasma to modulate precisely controlling activation transient receptor vanilloid 1 (TRPV1) up-regulating exogenous calcium-responsive gene expression. Compared typical optogenetics, electrogenetics, mechanogenetics, our strategy perspective genetics toolbox downstream intracellular events.
Язык: Английский
Процитировано
5
Angewandte Chemie International Edition, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
The regulation of oxidative stress in living cells is essential for maintaining cellular processes and signal transduction. However, developing straightforward strategies to activate stress-sensitive membrane channels situ poses significant challenges. In this study, we present a chemiluminescence resonance energy transfer (CRET) system based on conjugated oligomer, oligo(p-phenylenevinylene)-imidazolium (OPV-Im), designed the activation transient receptor potential melastatin 2 (TRPM2) calcium by superoxide anion (O2⋅-) without requiring external light sources. OPV-Im oligomer targeted cell efficiently, leading TRPM2 CRET process subsequent intracellular overload. This cascade resulted mitochondrial damage inhibition autophagy, ultimately inducing apoptosis. Additionally, strategy could be applied selective killing tumor that overexpress ion inhibiting growth three-dimensional (3D) spheroids. Our offers novel approach regulating channel activity compared optogenetics photodynamic therapy.
Язык: Английский
Процитировано
0
Angewandte Chemie, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
Abstract The regulation of oxidative stress in living cells is essential for maintaining cellular processes and signal transduction. However, developing straightforward strategies to activate stress‐sensitive membrane channels situ poses significant challenges. In this study, we present a chemiluminescence resonance energy transfer (CRET) system based on conjugated oligomer, oligo( p ‐phenylenevinylene)‐imidazolium (OPV−Im), designed the activation transient receptor potential melastatin 2 (TRPM2) calcium by superoxide anion (O ⋅ − ) without requiring external light sources. OPV−Im oligomer targeted cell efficiently, leading TRPM2 CRET process subsequent intracellular overload. This cascade resulted mitochondrial damage inhibition autophagy, ultimately inducing apoptosis. Additionally, strategy could be applied selective killing tumor that overexpress ion inhibiting growth three‐dimensional (3D) spheroids. Our offers novel approach regulating channel activity compared optogenetics photodynamic therapy.
Язык: Английский
Процитировано
0
Journal of Fluorescence, Год журнала: 2025, Номер unknown
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
0
Advanced Materials Technologies, Год журнала: 2025, Номер unknown
Опубликована: Фев. 21, 2025
Abstract To meet the growing demand for flexible wearable devices in information era, development of cost‐effective, easy‐processable, and mechanically sound luminescent materials is pivotal but remains challenging. Here, a facile one‐step melt mixing strategy reported to prepare reprocessable polyethylene with high stable fluorescence (f‐PE) using low‐density (LDPE) high‐dosages benzoyl peroxide (BPO) as raw materials. Typically, after 30 min 50 g LDPE 1 BPO 110‐rpm mixer, resulting f‐PE exhibited fluorescent brightness remarkable stability. In addition good mechanical properties, also demonstrated excellent processability can be processed conventional processing methods normal PE. Based on results, extended through‐space n‐π*/π‐π* interactions from high‐content BPO‐induced extensive grafting oxygen‐containing functional groups main chain proposed, well scissions rearrangement under strong shearing, may factors contribute processable properties. Thanks advantages such cost‐effective materials, scalable solvent‐free production, its preparation technique show great potential applications, bringing new opportunities functionalizing traditional versatile
Язык: Английский
Процитировано
0
Talanta, Год журнала: 2025, Номер 290, С. 127833 - 127833
Опубликована: Фев. 25, 2025
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Март 6, 2025
In the past decades, conjugated polyelectrolytes (CPEs) have become prominent in sensing applications due to their unique properties, including strong and tunable light absorption, high sensitivity, water solubility, biocompatibility. Inspired by mammalian olfactory gustatory systems, CPE-based sensor arrays made significant strides discriminating structurally similar analytes complex mixtures for various applications. This review consolidates recent advancements arrays, highlighting rational design, controllable fabrication, effective data processing methods. It covers fundamentals of CPE fluorescence sensing, emphasizing design strategies array units techniques. The broad applicability is demonstrated across diverse domains, environmental monitoring (e.g., detecting metal ions explosives), medical diagnostics disease markers analyzing biological samples), food safety assessing freshness, quality, source products). Further, challenges future directions field are discussed inspire further research development this area.
Язык: Английский
Процитировано
0
Advances in Materials Science, Год журнала: 2025, Номер 25(1), С. 5 - 36
Опубликована: Март 1, 2025
Abstract This leading-edge overview delivers an all-inclusive knowledge on fundamentals, state-of-the-art, and technicalities of two important polymer categories filled with graphene quantum dots, namely conjugated polymer/graphene dots rubber/graphene nanocomposites. According to the literature up till now, facile efficient fabrication methods, like in situ polymerization, solution mixing, melt blending, etc. have been reported for these derived hybrids. The ensuing based nanocomposites were inspected microstructural, electrical conductivity, charge transportation, thermal/mechanical resistance, fluorescence properties, allied valuable physical features. Incidentally, we notice promising applications inimitable hybrids gas/molecular/piezoelectric sensors, supercapacitors, biomedical areas. Nevertheless, due limited reports applied sides conjugated/rubbery matrices, future research attempts seem indispensable resolve challenges optimized/controlled processing also unveil structure-property-performance links synergistic mechanisms developing next generation industrial level
Язык: Английский
Процитировано
0