A Survey of Recent Developments in Magnetic Microrobots for Micro-/Nano-Manipulation
Micromachines,
Год журнала:
2024,
Номер
15(4), С. 468 - 468
Опубликована: Март 29, 2024
Magnetically
actuated
microrobots
have
become
a
research
hotspot
in
recent
years
due
to
their
tiny
size,
untethered
control,
and
rapid
response
capability.
Moreover,
an
increasing
number
of
researchers
are
applying
them
for
micro-/nano-manipulation
the
biomedical
field.
This
survey
provides
comprehensive
overview
developments
magnetic
microrobots,
focusing
on
materials,
propulsion
mechanisms,
design
strategies,
fabrication
techniques,
diverse
applications.
The
exploration
biosafety
considerations,
methods
serves
as
foundation
designs
discussed
this
review.
paper
delves
into
categories,
encompassing
helical,
surface,
ciliary,
scaffold,
biohybrid
with
each
demonstrating
unique
capabilities.
Furthermore,
various
including
direct
laser
writing,
glancing
angle
deposition,
biotemplating
synthesis,
template-assisted
electrochemical
self-assembly,
examined
owing
contributions
realization
microrobots.
potential
impact
across
multidisciplinary
domains
is
presented
through
application
areas,
such
drug
delivery,
minimally
invasive
surgery,
cell
manipulation,
environmental
remediation.
review
highlights
summary
current
challenges,
hurdles
overcome,
future
directions
microrobot
different
fields.
Язык: Английский
Magnetic Micro/nanorobots in Cancer Theranostics: From Designed Fabrication to Diverse Applications
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Cancer
poses
a
substantial
threat
and
serious
challenge
to
public
human
health,
driving
the
promotion
of
sophisticated
technologies
for
cancer
therapy.
While
conventional
chemotherapy
has
bottlenecks
such
as
low
delivery
efficiency,
strong
toxic
side
effects,
tumor
enrichment
barriers,
magnetic
micro/nanorobots
(MNRs)
emerge
promising
therapeutic
candidates
that
provide
alternative
strategies
MNR
is
kind
human-made
machine
micro-
or
nanosized,
reasonably
designed,
performs
command
tasks
through
self-actuated
externally
controlled
propulsion
mechanisms,
which
can
be
potentially
applied
in
theranostics.
Here,
this
review
first
introduces
components
constitute
typical
MNR,
including
body
part,
control
function
sensing
part.
Subsequently,
elucidates
representative
fabrication
methods
construct
MNRs
from
top-down
approaches
bottom-up
approaches,
covering
injection
molding,
self-rolling,
melt
electrospinning
writing,
deposition,
biotemplate
method,
lithography,
assembling,
3D
printing,
chemical
synthesis.
Furthermore,
focuses
on
multiple
applications
facing
diagnosis
treatment,
encompassing
imaging,
quantification,
drug
release,
synergy
with
therapies,
cell
manipulation,
surgical
assistance.
Then,
systematically
elaborates
biocompatibility
biosafety
MNRs.
Finally,
challenges
faced
by
are
discussed
alongside
future
research
directions.
This
intended
scientific
guidance
may
improve
comprehension
cognition
theranostics
platform
MNRs,
promoting
prospering
practical
application
development
Язык: Английский
A Naturally Inspired Extrusion‐Based Microfluidic Approach for Manufacturing Tailorable Magnetic Soft Continuum Microrobotic Devices
Advanced Materials,
Год журнала:
2024,
Номер
36(31)
Опубликована: Май 23, 2024
Soft
materials
play
a
crucial
role
in
small-scale
robotic
applications
by
closely
mimicking
the
complex
motion
and
morphing
behavior
of
organisms.
However,
conventional
fabrication
methods
face
challenges
creating
highly
integrated
soft
devices.
In
this
study,
microfluidics
is
leveraged
to
precisely
control
reaction-diffusion
(RD)
processes
generate
multifunctional
compartmentalized
calcium-cross-linkable
alginate-based
microfibers.
Under
RD
conditions,
sophisticated
fibers
are
produced
for
magnetic
continuum
robotics
with
customizable
features,
such
as
geometry
(compact
or
hollow),
degree
cross-linking,
precise
localization
nanoparticles
(inside
core,
surrounding
fiber,
on
one
side).
This
fine
allows
tuning
stiffness
responsiveness
Additionally,
chemically
cleavable
regions
within
enable
disassembly
into
smaller
units
roll-up
structures
under
rotating
field.
These
findings
demonstrate
versatility
processing
Язык: Английский
Magnetically Switchable Adhesive Millirobots for Universal Manipulation in both Air and Water
Zhiang Zhang,
Ruokun He,
Bing Han
и другие.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Abstract
Magnetic
soft
robots
with
multimodal
locomotion
have
demonstrated
significant
potential
for
target
manipulation
tasks
in
hard‐to‐reach
spaces
recent
years.
Achieving
universal
between
and
their
targets
requires
a
nondestructive
easily
switchable
interaction
broad
applicability
across
diverse
targets.
However,
establishing
versatile
dynamic
interactions
robotic
systems
remains
challenge.
Herein,
series
of
magnetic
millirobots
capable
magnetically
adhesion
is
reported.
Through
two‐photon
lithography‐assisted
molding,
double‐reentrant
micropillar
arrays
liquid
repellency
are
fabricated
on
the
robots.
These
can
serve
as
units
to
effectively
manipulate
various
geometries
(0D,
1D,
2D,
3D)
both
air
water.
As
proof‐of‐concept
demonstrations,
these
adhesive
perform
complex
tasks,
including
circuit
repair,
mini‐turbine
assembly,
high‐speed
underwater
rotation
turbine
machine.
This
work
may
offer
approach
non‐magnetic
objects
through
amphibious
adhesion,
emerging
new
paradigm
manipulation.
Язык: Английский
Magnetically Guided Microcatheter for Targeted Injection of Magnetic Particle Swarms
Advanced Science,
Год журнала:
2024,
Номер
11(38)
Опубликована: Авг. 9, 2024
The
initial
delivery
of
small-scale
magnetic
devices
such
as
microrobots
is
a
key,
but
often
overlooked,
aspect
for
their
use
in
clinical
applications.
deployment
these
within
the
dynamic
environment
human
body
presents
significant
challenges
due
to
dispersion
caused
by
circulatory
flows.
Here,
method
introduced
effectively
deliver
swarm
nanoparticles
fluidic
This
approach
integrates
magnetically
navigated
robotic
microcatheter
equipped
with
reservoir
storing
nanoparticles.
microfluidic
flow
facilitates
injection
into
fluid
stream,
and
field
gradient
guides
through
oscillatory
target
site.
are
engineered
enable
steering
To
demonstrate
this
approach,
experiments
conducted
utilizing
spinal
cord
phantom
simulating
intrathecal
catheter
applications
central
nervous
system.
These
results
that
proposed
successfully
concentrates
near
desired
location
precise
manipulation
gradients,
offering
promising
solution
controlled
untethered
micro-/nanodevices
complex
physiological
systems
body.
Язык: Английский
Magnetoelectric Microrobots for Spinal Cord Injury Regeneration
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 8, 2024
ABSTRACT
Regenerative
medicine
continually
seeks
effective
methods
to
address
spinal
cord
injuries
(SCI),
which
are
known
for
their
limited
regenerative
potential.
Despite
advances
in
neural
progenitor
cell
(NPC)
transplants
injuries,
challenges
related
graft
survival,
reliable
vivo
differentiation,
and
integration
significantly
hinder
real
functional
recovery
limit
clinical
outcomes.
This
study
introduces
‘NPCbots’,
biohybrid
microrobots
engineered
by
integrating
human-induced
pluripotent
stem
cell-derived
NPCs
with
magnetoelectric
nanoparticles
composed
of
cobalt
ferrite-barium
titanate.
These
enable
magnetic
navigation
neuronal
stimulation,
enhancing
targeted
therapeutic
interventions.
Our
lab-on-a-chip
system
allows
the
mass
production
NPCbots,
ensuring
differentiation
biocompatibility.
Remarkably,
a
zebrafish
model
SCI,
NPCbots
stimulated
an
alternating
field
demonstrated
rapid
into
damaged
pathways,
regeneration.
Within
three
days,
injured
treated
exhibited
almost
normal
swimming
behavior
improved
exploratory
behavior,
showcasing
potential
swiftly
repair
structures
restore
central
nervous
system’s
functionality
injury
models
through
non-invasive
means.
Additionally,
precise
vitro
manipulation
indicates
broader
application
various
neurodegenerative
disorders,
offering
promising
route
neurological
recovery.
Язык: Английский
Shape‐Morphing in Oxide Ceramic Kirigami Nanomembranes
Advanced Materials,
Год журнала:
2024,
Номер
36(47)
Опубликована: Окт. 10, 2024
Interfacial
strain
engineering
in
ferroic
nanomembranes
can
broaden
the
scope
of
nanomembrane
assembly
as
well
facilitate
multiferroic-based
devices
with
enhanced
functionalities.
Geometrical
these
material
systems
enables
realization
3-D
architectures
unconventional
physical
properties.
Here,
multiferroic
are
introduced
by
incorporating
barium
titanate
(BaTiO
Язык: Английский
Single‐Step Synthesis of Sub‐10 nm Magnetic Nanoparticles with High Saturation Magnetization and Broad pH Stability
Advanced Engineering Materials,
Год журнала:
2024,
Номер
26(20)
Опубликована: Авг. 3, 2024
Iron
oxide
nanoparticles
hold
great
potential
for
future
biomedical
applications
but,
to
date,
usually
suffer
from
reduced
magnetic
properties
compared
their
bulk
counterparts.
The
replacement
of
Fe(III)
ions
with
Zn(II)
can
enhance
while
keeping
biocompatibility
characteristics.
Yet,
common
synthesis
methods
these
highly
particles
require
using
environmentally
harmful
solvents,
multiple
steps,
and
postfunctionalization,
all
being
affected
by
poor
scalability
high
polydispersity.
To
address
challenges,
in
this
study,
a
single‐step
coprecipitation‐based
method
is
developed
fabricate
gelatin‐coated,
zinc‐substituted,
sub‐10
nm‐sized
iron
exhibiting
saturation
magnetization.
This
benefits
simplicity
robustness,
capable
yielding
large
amounts
without
the
utilization
or
toxic
reagents.
Furthermore,
situ
gelatin
coating
during
ensures
particle
stability
aqueous
solutions
over
wide
range
pH
enhances
cell
compatibility.
Systematic
investigations
show
direct
correlation
between
particles’
magnetization
concentrations
NaOH,
where
zinc‐to‐iron
ratio
Zn:Fe
=
0.18:2.82
reach
maximum
91.2
emu
g
−1
.
Thus,
are
promising
candidates
applications.
Язык: Английский