Single‐Step Synthesis of Sub‐10 nm Magnetic Nanoparticles with High Saturation Magnetization and Broad pH Stability DOI Creative Commons

Vitaly Pustovalov,

Fabian C. Landers,

Lukas Hertle

et al.

Advanced Engineering Materials, Journal Year: 2024, Volume and Issue: 26(20)

Published: Aug. 3, 2024

Iron oxide nanoparticles hold great potential for future biomedical applications but, to date, usually suffer from reduced magnetic properties compared their bulk counterparts. The replacement of Fe(III) ions with Zn(II) can enhance while keeping biocompatibility characteristics. Yet, common synthesis methods these highly particles require using environmentally harmful solvents, multiple steps, and postfunctionalization, all being affected by poor scalability high polydispersity. To address challenges, in this study, a single‐step coprecipitation‐based method is developed fabricate gelatin‐coated, zinc‐substituted, sub‐10 nm‐sized iron exhibiting saturation magnetization. This benefits simplicity robustness, capable yielding large amounts without the utilization or toxic reagents. Furthermore, situ gelatin coating during ensures particle stability aqueous solutions over wide range pH enhances cell compatibility. Systematic investigations show direct correlation between particles’ magnetization concentrations NaOH, where zinc‐to‐iron ratio Zn:Fe = 0.18:2.82 reach maximum 91.2 emu g −1 . Thus, are promising candidates applications.

Language: Английский

A Survey of Recent Developments in Magnetic Microrobots for Micro-/Nano-Manipulation DOI Creative Commons
Ruomeng Xu, Qingsong Xu

Micromachines, Journal Year: 2024, Volume and Issue: 15(4), P. 468 - 468

Published: March 29, 2024

Magnetically actuated microrobots have become a research hotspot in recent years due to their tiny size, untethered control, and rapid response capability. Moreover, an increasing number of researchers are applying them for micro-/nano-manipulation the biomedical field. This survey provides comprehensive overview developments magnetic microrobots, focusing on materials, propulsion mechanisms, design strategies, fabrication techniques, diverse applications. The exploration biosafety considerations, methods serves as foundation designs discussed this review. paper delves into categories, encompassing helical, surface, ciliary, scaffold, biohybrid with each demonstrating unique capabilities. Furthermore, various including direct laser writing, glancing angle deposition, biotemplating synthesis, template-assisted electrochemical self-assembly, examined owing contributions realization microrobots. potential impact across multidisciplinary domains is presented through application areas, such drug delivery, minimally invasive surgery, cell manipulation, environmental remediation. review highlights summary current challenges, hurdles overcome, future directions microrobot different fields.

Language: Английский

Citations

15
Magnetic Micro/nanorobots in Cancer Theranostics: From Designed Fabrication to Diverse Applications DOI
Lin Zhang, Shuren Wang, Yanglong Hou

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Cancer poses a substantial threat and serious challenge to public human health, driving the promotion of sophisticated technologies for cancer therapy. While conventional chemotherapy has bottlenecks such as low delivery efficiency, strong toxic side effects, tumor enrichment barriers, magnetic micro/nanorobots (MNRs) emerge promising therapeutic candidates that provide alternative strategies MNR is kind human-made machine micro- or nanosized, reasonably designed, performs command tasks through self-actuated externally controlled propulsion mechanisms, which can be potentially applied in theranostics. Here, this review first introduces components constitute typical MNR, including body part, control function sensing part. Subsequently, elucidates representative fabrication methods construct MNRs from top-down approaches bottom-up approaches, covering injection molding, self-rolling, melt electrospinning writing, deposition, biotemplate method, lithography, assembling, 3D printing, chemical synthesis. Furthermore, focuses on multiple applications facing diagnosis treatment, encompassing imaging, quantification, drug release, synergy with therapies, cell manipulation, surgical assistance. Then, systematically elaborates biocompatibility biosafety MNRs. Finally, challenges faced by are discussed alongside future research directions. This intended scientific guidance may improve comprehension cognition theranostics platform MNRs, promoting prospering practical application development

Language: Английский

Citations

1
A Naturally Inspired Extrusion‐Based Microfluidic Approach for Manufacturing Tailorable Magnetic Soft Continuum Microrobotic Devices DOI

Lukas Hertle,

Semih Sevim, Jiawei Zhu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: May 23, 2024

Soft materials play a crucial role in small-scale robotic applications by closely mimicking the complex motion and morphing behavior of organisms. However, conventional fabrication methods face challenges creating highly integrated soft devices. In this study, microfluidics is leveraged to precisely control reaction-diffusion (RD) processes generate multifunctional compartmentalized calcium-cross-linkable alginate-based microfibers. Under RD conditions, sophisticated fibers are produced for magnetic continuum robotics with customizable features, such as geometry (compact or hollow), degree cross-linking, precise localization nanoparticles (inside core, surrounding fiber, on one side). This fine allows tuning stiffness responsiveness Additionally, chemically cleavable regions within enable disassembly into smaller units roll-up structures under rotating field. These findings demonstrate versatility processing

Language: Английский

Citations

4
Magnetically Switchable Adhesive Millirobots for Universal Manipulation in both Air and Water DOI

Zhiang Zhang,

Ruokun He,

Bing Han

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Magnetic soft robots with multimodal locomotion have demonstrated significant potential for target manipulation tasks in hard‐to‐reach spaces recent years. Achieving universal between and their targets requires a nondestructive easily switchable interaction broad applicability across diverse targets. However, establishing versatile dynamic interactions robotic systems remains challenge. Herein, series of magnetic millirobots capable magnetically adhesion is reported. Through two‐photon lithography‐assisted molding, double‐reentrant micropillar arrays liquid repellency are fabricated on the robots. These can serve as units to effectively manipulate various geometries (0D, 1D, 2D, 3D) both air water. As proof‐of‐concept demonstrations, these adhesive perform complex tasks, including circuit repair, mini‐turbine assembly, high‐speed underwater rotation turbine machine. This work may offer approach non‐magnetic objects through amphibious adhesion, emerging new paradigm manipulation.

Language: Английский

Citations

0
Magnetically Guided Microcatheter for Targeted Injection of Magnetic Particle Swarms DOI Creative Commons
Harun Torlakcik, Semih Sevim,

Pedro Alves

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)

Published: Aug. 9, 2024

The initial delivery of small-scale magnetic devices such as microrobots is a key, but often overlooked, aspect for their use in clinical applications. deployment these within the dynamic environment human body presents significant challenges due to dispersion caused by circulatory flows. Here, method introduced effectively deliver swarm nanoparticles fluidic This approach integrates magnetically navigated robotic microcatheter equipped with reservoir storing nanoparticles. microfluidic flow facilitates injection into fluid stream, and field gradient guides through oscillatory target site. are engineered enable steering To demonstrate this approach, experiments conducted utilizing spinal cord phantom simulating intrathecal catheter applications central nervous system. These results that proposed successfully concentrates near desired location precise manipulation gradients, offering promising solution controlled untethered micro-/nanodevices complex physiological systems body.

Language: Английский

Citations

2
Magnetoelectric Microrobots for Spinal Cord Injury Regeneration DOI Open Access
Hao Ye, Jingjing Zang, Jiawei Zhu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

ABSTRACT Regenerative medicine continually seeks effective methods to address spinal cord injuries (SCI), which are known for their limited regenerative potential. Despite advances in neural progenitor cell (NPC) transplants injuries, challenges related graft survival, reliable vivo differentiation, and integration significantly hinder real functional recovery limit clinical outcomes. This study introduces ‘NPCbots’, biohybrid microrobots engineered by integrating human-induced pluripotent stem cell-derived NPCs with magnetoelectric nanoparticles composed of cobalt ferrite-barium titanate. These enable magnetic navigation neuronal stimulation, enhancing targeted therapeutic interventions. Our lab-on-a-chip system allows the mass production NPCbots, ensuring differentiation biocompatibility. Remarkably, a zebrafish model SCI, NPCbots stimulated an alternating field demonstrated rapid into damaged pathways, regeneration. Within three days, injured treated exhibited almost normal swimming behavior improved exploratory behavior, showcasing potential swiftly repair structures restore central nervous system’s functionality injury models through non-invasive means. Additionally, precise vitro manipulation indicates broader application various neurodegenerative disorders, offering promising route neurological recovery.

Language: Английский

Citations

1
Shape‐Morphing in Oxide Ceramic Kirigami Nanomembranes DOI Creative Commons
Min‐Soo Kim, Dong‐Hoon Kim, Mathieu Mirjolet

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(47)

Published: Oct. 10, 2024

Interfacial strain engineering in ferroic nanomembranes can broaden the scope of nanomembrane assembly as well facilitate multiferroic-based devices with enhanced functionalities. Geometrical these material systems enables realization 3-D architectures unconventional physical properties. Here, multiferroic are introduced by incorporating barium titanate (BaTiO

Language: Английский

Citations

1
Single‐Step Synthesis of Sub‐10 nm Magnetic Nanoparticles with High Saturation Magnetization and Broad pH Stability DOI Creative Commons

Vitaly Pustovalov,

Fabian C. Landers,

Lukas Hertle

et al.

Advanced Engineering Materials, Journal Year: 2024, Volume and Issue: 26(20)

Published: Aug. 3, 2024

Iron oxide nanoparticles hold great potential for future biomedical applications but, to date, usually suffer from reduced magnetic properties compared their bulk counterparts. The replacement of Fe(III) ions with Zn(II) can enhance while keeping biocompatibility characteristics. Yet, common synthesis methods these highly particles require using environmentally harmful solvents, multiple steps, and postfunctionalization, all being affected by poor scalability high polydispersity. To address challenges, in this study, a single‐step coprecipitation‐based method is developed fabricate gelatin‐coated, zinc‐substituted, sub‐10 nm‐sized iron exhibiting saturation magnetization. This benefits simplicity robustness, capable yielding large amounts without the utilization or toxic reagents. Furthermore, situ gelatin coating during ensures particle stability aqueous solutions over wide range pH enhances cell compatibility. Systematic investigations show direct correlation between particles’ magnetization concentrations NaOH, where zinc‐to‐iron ratio Zn:Fe = 0.18:2.82 reach maximum 91.2 emu g −1 . Thus, are promising candidates applications.

Language: Английский

Citations

0