Abstract
Low‐temperature
second
near‐infrared
region
(NIR‐II)
photothermal
therapy
(PTT)
has
shown
significant
potential
in
minimizing
damage
to
normal
tissues
and
reducing
inflammation.
However,
it
still
faces
challenge
of
insufficient
immune
response.
Thus,
a
multifunctional
phototheranostic
nanoparticle
(BDPB/Pt/Fe@P[5])
is
developed
by
co‐loading
BDPB,
CDHPt,
Fe
2
⁺
with
pH‐sensitive
lipid
DSPE‐PEOz2K.
The
carboxylatopillar[5]arene
(CP[5])
used
construct
this
exhibits
strong
host–guest
recognition
pyridine
salts,
alleviating
aggregation
caused
quench
(ACQ)
effect
enhancing
the
NIR‐II
emission
donor–acceptor–donor
(D–A–D)‐type
organic
small
molecule
(BDPB).
CP[5]
provides
suitable
vehicles
for
encapsulating
platinum
(IV)
prodrugs
(CDHPt)
ions
via
metal
coordination
controllable
reactive
oxygen
species
(ROS)
release.
Under
low‐intensity
laser
irradiation
an
acidic
tumor
microenvironment,
nanoparticles
degrade,
releasing
CDHPt
platinum‐based
chemodynamic
(CDT).
facilitates
direct
production
superoxide
anions
(O₂·⁻)
from
O₂
partially
converts
into
highly
cytotoxic
hydroxyl
radicals,
thereby
promoting
Fenton
reaction
process.
therapeutic
efficacy
further
synergized
immunogenic
cell
death
(ICD)
effect.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
The
cGAS‐STING
pathway
is
pivotal
in
initiating
antitumor
immunity.
However,
tumor
metabolism,
particularly
glycolysis,
negatively
regulates
the
activation
of
pathway.
Herein,
Mn
galvanic
cells
(MnG)
are
prepared
via
liquid‐phase
exfoliation
and
situ
replacement
to
modulate
thereby
enhancing
for
bidirectional
synergistic
H
2
‐immunotherapy.
obtained
MnG
can
be
etched
by
water,
enabling
efficient
sustained
generation
gas
2+
.
not
only
activated
amplified
through
release
but
also
regulated
glucose
metabolism
inhibit
expression
three
prime
repair
exonuclease
(TREX2),
synergistically
injection
into
tumors
resulted
a
robust
immune
response,
providing
favorable
support
therapy.
Consequently,
combination
with
checkpoint
blockade
therapy
significant
suppression
both
primary
distant
tumors.
Furthermore,
MnG‐lipiodol
dispersion
exhibited
remarkable
efficacy
transarterial
embolization
(TAE)‐gas‐immunotherapy
rabbit
orthotopic
liver
model.
present
study
underscores
significance
employing
metal
cell
strategy
enhanced
immunotherapy,
offering
novel
approach
rational
design
bioactive
materials
augment
immunotherapeutic
effectiveness.
Biomacromolecules,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 11, 2024
Glioblastoma
multiforme
(GBM)
is
a
highly
malignant
brain
tumor
with
poor
prognosis
and
limited
treatment
options.
Drug
delivery
by
stimuli-responsive
nanocarriers
holds
great
promise
for
improving
the
modalities
of
GBM.
At
beginning
review,
we
highlighted
stimuli-active
polymeric
carrying
therapies
that
potentially
boost
anti-GBM
responses
employing
endogenous
(pH,
redox,
hypoxia,
enzyme)
or
exogenous
stimuli
(light,
ultrasonic,
magnetic,
temperature,
radiation)
as
triggers
controlled
drug
release
mainly
via
hydrophobic/hydrophilic
transition,
degradability,
ionizability,
etc.
Modifying
these
target
ligands
further
enhanced
their
capacity
to
traverse
blood-brain
barrier
(BBB)
preferentially
accumulate
in
glioma
cells.
These
unique
features
lead
more
effective
cancer
minimal
adverse
reactions
superior
therapeutic
outcomes.
Finally,
review
summarizes
existing
difficulties
future
prospects
treating
Overall,
this
offers
theoretical
guidelines
developing
intelligent
versatile
facilitate
precise
GBM
clinical
settings.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(46)
Опубликована: Июнь 10, 2024
Abstract
Immunotherapy,
one
of
the
most
promising
antitumor
strategies,
is
used
to
treat
prostate
cancer
(PCa).
However,
owing
immunosuppressive
tumor
microenvironment
(TME),
therapeutic
effect
immune
response
greatly
weakened.
Therefore,
there
an
urgent
need
explore
new
methods
enhance
responses.
In
this
study,
a
single‐atom
nanozyme
platform
(Cu
SA‐DOX@COD)
that
can
trigger
pyroptosis
developed
activate
responses
via
gasdermin
E
(GSDME)‐dependent
pathway.
It
triggered
by
catalyzing
production
reactive
oxygen
species
(ROS)
and
depleting
reduced
glutathione
through
intrinsic
multi‐enzyme
simulated
activities
providing
source
for
cholesterol
(CHOL)
oxidation.
Meanwhile,
loaded
CHOL
oxidase
not
only
reduces
content
cells
increase
cell
membrane
permeability
inhibit
proliferation
invasion
but
also
oxidizes
increases
level
H
2
O
in
pyroptosis.
addition,
doxorubicin
activated
caspase‐3
cleave
GSDME
further
augment
Consequently,
Cu
SA‐DOX@COD
enhances
immunocompetence
reshapes
TME
triggering
caused
ROS
storm,
chemotherapy,
CHOL,
thereby
activating
systemic
immunity
PCa.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Although
cytotoxic
T
lymphocytes
(CTLs)
activation
combined
with
programmed
cell
death‐1
(PD‐1)/programmed
death
ligand‐1
(PD‐L1)
axis
blockade
have
emerged
as
an
effective
strategy
to
improve
immunotherapeutic
potency,
it
remains
challenging
realize
the
spatiotemporal
synergy
of
these
two
components.
Herein,
study
reports
engineered
bacterial‐based
delivery
system
that
can
simultaneously
promote
CTLs
infiltration
and
control
PD‐L1
binding
protein
(PD‐L1
trap)
release
on
demand
at
tumor
site.
The
drug
button
this
targeting
is
specific
temperature,
which
accomplished
by
dual‐modified
melanin
nanoparticles
photothermal
conversion
capacity
bacterial.
These
form
in
situ
reservoir
heat
supplier
antitumor
immunity
activator
once
arriving
microenvironment
(TME).
Importantly,
establishes
personalized
administration
regimen
according
TME
changes,
perform
local
laser
irradiation
trigger
trap
production
only
when
infiltrated
reach
highest
level.
This
work
provides
a
flexible
platform
for
optimizing
cancer
immunotherapy.
Theranostics,
Год журнала:
2025,
Номер
15(9), С. 4147 - 4174
Опубликована: Март 15, 2025
Magnetic
resonance
imaging
(MRI)
guidance
in
the
realm
of
anticancer
therapy
is
crucial
to
visualize
spread
tumors
deep
tissues,
accumulate
therapeutics,
and
trigger
them
for
precise
therapy.
Recent
studies
bridge
this
gap
by
integrating
MRI
contrast
agents
(CAs)
with
different
therapeutic
regimes
a
better
outcome.
In
context,
manganese-based
materials
hold
great
potential
owing
their
T1/T2
dual-modal
MR-relaxation,
less
toxicity,
other
capabilities
such
as
chemodynamic
therapy,
immunotherapy,
etc.,
which
have
gained
increasing
interest
among
researchers
medical
professionals.
This
work
offers
timely
update
on
last
three
years
Mn-based
MRI-guided
theranostic
applications,
including
chemotherapy,
photo
therapies,
sonodynamic
radiotherapy
against
cancer.
Further,
several
combinatory
therapies
surgical
intersections
also
been
summarized
light
guidance.
The
design
rationale
these
has
discussed
understand
existing
challenges
plausible
outcomes
shortly.
Herein,
we
dive
into
stimulus-based
probes
pH,
temperature,
etc.
show
unexplored
Mn-complexes
domain.
state-of-the-art
review
will
guide
innovations
CAs
expedite
safer
modules
clinical
translation.
