Journal of Colloid and Interface Science, Год журнала: 2024, Номер 677, С. 941 - 952
Опубликована: Авг. 5, 2024
Язык: Английский
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Сен. 28, 2024
Язык: Английский
Процитировано
17
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(32), С. 22675 - 22688
Опубликована: Авг. 1, 2024
Redox-responsive homodimer prodrug nanoassemblies (RHPNs) have emerged as a significant technology for overcoming chemotherapeutical limitations due to their high drug-loading capacity, low excipient-associated toxicity, and straightforward preparation method. Previous studies indicated that α-position disulfide bond bridged RHPNs exhibited rapid drug release rates but unsatisfactory assembly stability. In contrast, γ-disulfide showed better stability rates. Therefore, designing chemical linkages ensure both stable remains challenging. To address this paradox of in RHPNs, we developed carbon-spaced double-disulfide (CSDD)-bridged (CSDD-RHPNs) with two carbon-spaces. Pilot CSDD-RHPNs carbon-spaces enhanced stability, reduction-responsive release, improved selective toxicity compared α-/γ-position single RHPNs. Based on these findings, four six were designed further investigate the properties CSDD-RHPNs. These excellent ability, safety, prolonged circulation. Particularly, displayed best antitumor efficacy 4T1 B16–F10 tumor-bearing mice. CSDD offer novel perspectives rational design potentially regarding contradictory ability rate.
Язык: Английский
Процитировано
11
ACS Nano, Год журнала: 2024, Номер 18(35), С. 23827 - 23841
Опубликована: Авг. 20, 2024
Carrier-free nanodrugs with extraordinary active pharmaceutical ingredient (API) loading (even 100%), avoidable carrier-induced toxicity, and simple synthetic procedures are considered as one of the most promising candidates for disease theranostics. Substantial studies commercial success "carrier-free" nanocrystals have demonstrated their strong clinical potential. However, practical translations remain challenging impeded by unpredictable assembly processes, insufficient delivery efficiency, an unclear in vivo fate. In this Perspective, we systematically outline contemporary emerging carrier-free based on diverse APIs, well highlight opportunities challenges translation. Looking ahead, further improvements design preparation, drug delivery, efficacy, safety nanomedicines essential to facilitate translation from bench bedside.
Язык: Английский
Процитировано
9
Materials Today Bio, Год журнала: 2024, Номер 27, С. 101145 - 101145
Опубликована: Июль 2, 2024
Tau protein aggregation is a defining characteristic of Alzheimer's disease (AD), leading to the formation neurofibrillary tangles that disrupt neural communication and ultimately result in cognitive decline. Nanotechnology presents novel strategies for both diagnosing treating disease. Nanotechnology. It has become revolutionary tool fight against disease, particularly addressing pathological accumulation tau protein. This review explores relationship between tau-related neurophysiology utilization nanotechnology AD treatment, focusing on application nanomaterials regulate phosphorylation, hinder propagation, stabilize microtubules, eliminate emphasize potential developing personalized therapies monitoring treatment responses patients. combines with provide new insights further understanding
Язык: Английский
Процитировано
8
International Journal of Pharmaceutics, Год журнала: 2024, Номер 669, С. 125050 - 125050
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
5
Fundamental Research, Год журнала: 2024, Номер unknown
Опубликована: Июнь 1, 2024
Mitoxantrone (MTO) is an anthraquinone antitumor drug with potent therapeutic benefits. However, its clinical application restricted by the severe side effects stemming from poor tumor selectivity. In this study, MTO and cholesterol (CLS) were conjugated via a tumor-selective disulfide bond to obtain MTO-SS-CLS prodrug. Interestingly, could self-assemble into uniform nanoassemblies, addition of DSPE-PEG2K significantly improved self-assembly behavior stability. Moreover, compared solutions, bond-bridged nanoassemblies exhibited heightened selectivity pharmacokinetic properties. addition, prodrug tolerated dose safety without compromising effect. This research enriches pharmaceutical paves way for extensive application.
Язык: Английский
Процитировано
4
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Abstract Chemo‐immunotherapy, combining systemic chemotherapeutic drugs and immune checkpoint blockers, is a promising paradigm in cancer treatment. However, challenges such as limited induction of responses toxicity have hindered its clinical applications. Here, zeolite imidazolate framework‐8 (ZIF‐8) that encapsulates mitoxantrone (MIT), an cell death (ICD)‐inducing agent (MIT@ZIF‐8), synthesized using one‐pot aqueous‐phase process. ZIF‐8 serves dual‐functional nanomaterial for chemo‐immunotherapy: carrier to enhance tumor uptake MIT improved chemotherapy efficacy, pyroptosis inducer amplify MIT‐induced ICD augmented anti‐tumor responses. As result, vivo administration MIT@ZIF‐8 markedly inhibits growth both immunologically “hot” colon “cold” prostate cancer. Moreover, treatment increases the abundance cytotoxic CD8 + T cells reduces amount immunosuppressive regulatory tumors, thereby enhancing immunity sensitizing anti‐CTLA‐4 immunotherapy. In summary, offers highly translational approach chemo‐immunotherapy.
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113546 - 113546
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161784 - 161784
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113699 - 113699
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0