Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 141 - 176
Опубликована: Янв. 1, 2025
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 496, С. 154226 - 154226
Опубликована: Июль 22, 2024
Язык: Английский
Процитировано
48
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(12), С. 5161 - 5180
Опубликована: Авг. 23, 2024
Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.
Язык: Английский
Процитировано
25
Advanced Materials, Год журнала: 2024, Номер 36(23)
Опубликована: Фев. 20, 2024
Abstract In recent years, tremendous effort is devoted to developing platforms, such as implantable drug delivery systems (IDDSs), with temporally and spatially controlled release capabilities improved adherence. IDDSs have multiple advantages: i) the timing location of can be by patients using specific stimuli (light, sound, electricity, magnetism, etc.). Some intelligent “closed‐loop” IDDS even realize self‐management without human participation. ii) enable continuous stable drugs over a long period (months years) iii) administer directly lesion, thereby helping reduce dosage side effects. iv) personalized according patient needs. The high demand for has prompted scientists make efforts develop IDDS. this review, several common stimulus‐responsive mechanisms including endogenous (e.g., pH, reactive oxygen species, proteins, etc.) exogenous light, etc.), are given in detail. Besides, types reported years reviewed, various based on above mechanisms, radio frequency‐controlled IDDS, self‐powered etc. Finally, advantages disadvantages bottleneck problems, possible solutions analyzed provide directions subsequent research.
Язык: Английский
Процитировано
13
International Journal of Pharmaceutics, Год журнала: 2024, Номер 663, С. 124547 - 124547
Опубликована: Авг. 2, 2024
Язык: Английский
Процитировано
10
Nanoscale, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
The emerging integrated power supplies for self-powered bioelectronic devices over the past few years are summarized. Additionally, challenges and future perspectives in device design manufacturing also indicated.
Язык: Английский
Процитировано
2
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
Ocular injury and infection are significant causes of vision impairment blindness globally. Effective treatment is, however, challenging due to the physical barrier cornea, which restricts drug penetration in eye, as well presence eye that necessitates continuous delivery growth factors on ocular surface for cornea healing. Here, we introduce a transformative wearable corneal microneedle (MN) patch designed efficient therapy infection. The MN comprises water-soluble tips encapsulate antibacterial nanoparticles (NPs), along with backing layer contains epidermal factor (EGF). Upon insertion into dissolve swiftly within stroma, resulting release antimicrobial NPs efficiently eradicate bacteria. Meanwhile, residual undergoes rapid situ transformation upon contact mildly acidic fluid from infected edema, converting lens conforms eye's surface, facilitates sustained EGF over 8 h promote Benefiting these features, demonstrates superior efficacy treating injuries infections vivo, offering promising therapeutic strategy manage diseases.
Язык: Английский
Процитировано
2
Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 539 - 562
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
2
Acta Biomaterialia, Год журнала: 2024, Номер 187, С. 20 - 50
Опубликована: Сен. 3, 2024
Язык: Английский
Процитировано
7
Drug Delivery and Translational Research, Год журнала: 2024, Номер unknown
Опубликована: Окт. 21, 2024
Abstract Transdermal drug delivery (TDD) using electrically assisted microneedle (MN) systems has emerged as a promising alternative to traditional administration routes. This review explores recent advancements in this technology across various therapeutic applications. Integrating iontophoresis (IP) and electroporation (EP) with MN shown significant potential improving treatment outcomes for conditions. Studies demonstrate their effectiveness enhancing vaccine DNA delivery, diabetes management, increasing efficacy dermatological The also exhibited promise delivering nonsteroidal anti-inflammatory drugs (NSAIDs), treating multiple sclerosis, advancing obesity cancer therapy. These offer improved permeation, targeted enhanced effects. While challenges remain, including safety concerns technological limitations, ongoing research focuses on optimizing these broader clinical future of technologies TDD appears promising, personalized medicine, smart monitoring systems, expanded Graphical
Язык: Английский
Процитировано
7
Nature Reviews Electrical Engineering, Год журнала: 2025, Номер unknown
Опубликована: Март 25, 2025
Язык: Английский
Процитировано
1