Bioactive Materials, Год журнала: 2024, Номер 46, С. 229 - 241
Опубликована: Дек. 20, 2024
Язык: Английский
AAPS PharmSciTech, Год журнала: 2025, Номер 26(1)
Опубликована: Янв. 8, 2025
Язык: Английский
Процитировано
4
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 298, С. 140010 - 140010
Опубликована: Янв. 17, 2025
Язык: Английский
Процитировано
4
Nano-Micro Letters, Год журнала: 2025, Номер 17(1)
Опубликована: Фев. 6, 2025
Abstract The use of microneedles (MNs) has been established as an effective transdermal drug delivery strategy that extensively deployed for treating various diseases, including skin diseases. MNs can surpass the constraints conventional methods by their superior safety and efficacy through precise targeting, while simultaneously enabling painless delivery. Currently, are increasingly used carriers delivery, with loading insoluble drugs to improve treatment efficiency or combining bioactive substances construction efficient system maximize effects substances. preparation diverse, them meet requirements most applications. emergence addressed shortcomings associated drugs, expanded applications substances, improved in clinical practice. This review summarizes current information on application a variety such psoriasis, vitiligo, alopecia, hypertrophic scarring, atopic dermatitis, melanoma, acne, infections. future opportunities diseases also discussed. Despite substantial progress vectors, issues low poor mechanical strength during remain main challenges. Therefore, implementation MNs-based therapies remains limited, highlighting key research.
Язык: Английский
Процитировано
2
Biosensors, Год журнала: 2025, Номер 15(3), С. 139 - 139
Опубликована: Фев. 23, 2025
Wound healing is a complicated biological process that important for restoring tissue integrity and function after injury. Infection, usually due to bacterial colonization, significantly complicates this by hindering the course of enhancing chances systemic complications. Recent advances in wearable biosensors have transformed wound care making real-time monitoring biomarkers such as pH, temperature, moisture, infection-related metabolites like trimethylamine uric acid. This review focuses on recent biosensor technologies designed management. Novel sensor architectures, flexible stretchable electronics, colorimetric patches, electrochemical platforms, enable non-invasive detection changes associated with wounds high specificity sensitivity. These are increasingly combined AI analytics based smartphones can timely personalized interventions. Examples PETAL patch applies multiple sensing mechanisms wide-ranging views status closed-loop systems connect therapeutic devices automate infection control. Additionally, self-powered tap into body heat or energy from biofluids themselves avoid any external batteries thus more effective field use limited resources. Internet Things connectivity allows further support remote sharing data, supporting telemedicine applications. Although developed relatively rapidly their prospects continue expand, regular clinical application stalled significant challenges regulatory, cost, patient compliance, technical problems related accuracy, biofouling, power, among others, need be addressed innovative solutions. The goal synthesize current trends, challenges, future directions monitoring, emphasis potential improve outcomes reduce healthcare burdens. innovations leading way toward next-generation bridging advanced materials science, biotechnology, digital health.
Язык: Английский
Процитировано
0
IntechOpen eBooks, Год журнала: 2025, Номер unknown
Опубликована: Фев. 27, 2025
Microneedles (MNs) have been used as active drug delivery carriers by precisely delivering drugs to the targeted site along with minimal tissue destruction. Earlier, MNs were for of transdermal site; now they are solid tumor site, mucosal, ophthalmic, and other organ site-specific delivery. considered a boon trans-barrier because routes, such systemic parenteral, face challenges limiting optimum amount reaching skin or barrier-containing organs. Hence, MN-mediated enhances permeation improves brain ciliary nasal clearance crossing barrier. The current book chapter mainly focuses on recent advancements in area MN-based into various parts body, their theragnostic applications, organs containing barriers, encounters has discussed. Also, comprehensive overview MN types, fabrication polymers, mechanisms release, effectiveness, advantages over conventional systems summarized.
Язык: Английский
Процитировано
0
European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113877 - 113877
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142273 - 142273
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 290, С. 117535 - 117535
Опубликована: Март 20, 2025
Cancer drug delivery remains a critical challenge with systemic toxicity, poor bioavailability, and lack of effective targeting. Overcoming these barriers is essential for improving treatment efficacy patient outcomes. This review discusses current techniques that reshape cancer therapy by offering precise, controlled-release tailored to tumor-specific features. Innovations in nanotechnology, immunotherapy, gene enable interventions at molecular cellular levels. Radiomics pathomics integrate high-dimensional data optimize diagnostics planning. Combination addresses the complexities tumor heterogeneity synergizing multiple agents within single therapeutic framework, while peptide-drug conjugates enhance specificity potency. Hydrogel-based systems microneedle arrays offer localized, sustained release, significantly However, clinical translation advancements faces significant such as resistance, off-target effects, scalability, cost, ethical concerns. Moreover, regulatory economic feasibility therapies highlight need innovative frameworks make them accessible globally. Therefore, there innovation cell therapy, next-generation platforms, personalized medicine. focuses on recent over past decade, evaluating their limitations exploring potential future directions transforming treatment.
Язык: Английский
Процитировано
0
Hybrid Advances, Год журнала: 2025, Номер unknown, С. 100447 - 100447
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
BioNanoScience, Год журнала: 2025, Номер 15(2)
Опубликована: Март 22, 2025
Язык: Английский
Процитировано
0