Theranostics,
Год журнала:
2025,
Номер
15(10), С. 4848 - 4860
Опубликована: Март 31, 2025
Rationale:
Endometriosis,
characterized
by
the
presence
of
ectopic
endometrial-like
tissue,
is
a
common
chronic
inflammatory
disorder
in
gynecology.
However,
current
treatments,
including
surgery
and
hormone
therapy,
often
yield
suboptimal
outcomes
significant
adverse
effects.
The
lack
drug
delivery
system
specifically
targeting
lesions
remains
major
barrier
to
development
more
effective
treatments.
Methods:
To
exploit
continuous
recruitment
neutrophils
elevated
reactive
oxygen
species
(ROS)
levels
within
endometriotic
lesions,
we
designed
ROS-responsive
liposome
(cLipo)
modified
with
neutrophil-targeting
peptides
on
its
surface.
A
minimally
invasive
mouse
model
endometriosis
was
used
assess
neutrophil-mediated
cLipo.
Additionally,
co-loaded
glucose
analog
2-deoxy-D-glucose
(2-DG)
autophagy
inhibitor
chloroquine
(CQ)
into
liposomes,
resulting
formulation
termed
cLipo-DC.
therapeutic
efficacy
cLipo-DC
evaluated
using
human
cells
(12Z),
endometrial
cancer
(Ishikawa),
an
model.
Results:
Although
neutrophil
hitchhiking
strategies
are
rarely
reported
diseases,
found
that
cLipo
bound
accumulated
following
intraperitoneal
injection
Subsequently,
vitro
experiments
showed
effectively
inhibited
glycolysis
both
12Z
Ishikawa
cells,
cell
death.
Furthermore,
vivo
administration
exerted
anti-endometriosis
effect,
no
detectable
side
Conclusions:
This
study
provides
novel
platform
for
non-hormonal
treatment
endometriosis.
This
review
explores
the
evolution
of
lipid-based
nanoparticles
(LBNPs)
for
drug
delivery
(DD).
Herein,
LBNPs
are
classified
into
liposomes
and
cell
membrane-based
(CMNPs),
each
with
unique
advantages
challenges.
Conventional
possess
drawbacks
such
as
poor
targeting,
quick
clearance,
limited
biocompatibility.
One
possible
alternatives
to
overcome
these
challenges
is
surface
modification
(NPs)
materials
polyethylene
glycol
(PEG),
aptamers,
antibody
fragments,
peptides,
CD44,
hyaluronic
acid,
folic
palmitic
lactoferrin.
Thus,
main
focus
this
will
be
on
different
modifications
that
enable
have
beneficial
properties
DD,
enhancing
mass
transport
properties,
immune
evasion,
improved
stability,
targeting.
Moreover,
various
CMNPs
explored
used
DD
derived
from
cells
red
blood
(RBCs),
platelets,
leukocytes,
cancer
cells,
stem
highlighting
their
natural
(e.g.,
biocompatibility
ability
evade
system).
discussion
extends
biomimicking
hybrid
NPs
accomplished
through
coating
synthetic
(mainly
polymeric)
membranes.
aims
provide
a
comprehensive
resource
researchers
recent
advances
in
field
CMNPs.
Overall,
provides
valuable
insights
dynamic
systems.
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(1), С. 8 - 8
Опубликована: Янв. 1, 2025
Each
year,
the
number
of
cases
strokes
and
deaths
due
to
this
is
increasing
around
world.
This
could
be
work
stress,
lifestyles,
unhealthy
food
habits,
several
other
reasons.
Currently,
there
are
traditional
methods
like
thrombolysis
mechanical
thrombectomy
for
managing
strokes.
The
current
approach
has
limitations,
delayed
diagnosis,
limited
therapeutic
delivery,
risks
secondary
injuries.
So,
a
need
some
effective
reliable
management
strokes,
which
help
in
early
diagnosis
followed
by
treatment
Nanotechnology
played
an
immense
role
recently,
it
emerged
as
transformative
solution
offering
innovative
diagnostic
tools
strategies.
Nanoparticles
(NPs)
belonging
classes,
including
metallic
(metallic
metal
oxide),
organic
(lipids,
liposome),
carbon,
can
cross
blood–brain
barrier
may
exhibit
potential
various
Moreover,
these
NPs
have
exhibited
promise
improving
imaging
specificity
delivery
precise
drug
real-time
monitoring
efficacy.
Nanomaterials
cerium
oxide
(CeO2)
liposome-encapsulated
agents
neuroprotective
properties
that
reduce
oxidative
stress
promote
neuroregeneration.
In
present
article,
authors
emphasized
significant
advancements
nanomedicine
stroke,
NPs-based
systems,
neuroregenerative
therapies,
multimodal
advancements.
Abstract
Extracellular
vesicles
(EVs)
are
heterogeneous
membrane-like
secreted
by
living
cells
that
involved
in
many
physiological
and
pathological
processes
act
as
intermediaries
of
intercellular
communication
molecular
transfer.
Recent
studies
have
shown
EVs
from
specific
sources
regulate
tissue
repair
regeneration
delivering
proteins,
lipids,
nucleic
acids
to
target
signaling
molecules.
Nanotechnology
breakthroughs
facilitated
the
development
exploration
engineered
for
repair.
Enhancements
through
gene
editing,
surface
modification,
content
modification
further
improved
their
therapeutic
efficacy.
This
review
summarizes
potential
regeneration,
mechanisms
action,
research
progress
regenerative
medicine.
highlights
design
logic
typical
examples
explores
prospects
The
aim
this
is
provide
new
insights
into
applications,
thereby
expanding
use
Abstract
Following
the
discovery
of
bone
as
an
endocrine
organ
with
systemic
influence,
bone-brain
interaction
has
emerged
a
research
hotspot,
unveiling
complex
bidirectional
communication
between
and
brain.
Studies
indicate
that
brain
can
influence
each
other’s
homeostasis
via
multiple
pathways,
yet
there
is
dearth
systematic
reviews
in
this
area.
This
review
comprehensively
examines
interactions
across
three
key
areas:
bone-derived
factors
on
function,
effects
brain-related
diseases
or
injuries
(BRDI)
health,
concept
skeletal
interoception.
Additionally,
discusses
innovative
approaches
biomaterial
design
inspired
by
mechanisms,
aiming
to
facilitate
through
materiobiological
aid
treatment
neurodegenerative
bone-related
diseases.
Notably,
integration
artificial
intelligence
(AI)
highlighted,
showcasing
AI’s
role
expediting
formulation
effective
targeted
strategies.
In
conclusion,
offers
vital
insights
into
mechanisms
suggests
advanced
harness
these
clinical
practice.
These
offer
promising
avenues
for
preventing
treating
impacting
skeleton
brain,
underscoring
potential
interdisciplinary
enhancing
human
health.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8539 - 8539
Опубликована: Авг. 5, 2024
Ischemic
stroke
is
a
serious
neurological
disease
involving
multiple
complex
physiological
processes,
including
vascular
obstruction,
brain
tissue
ischemia,
impaired
energy
metabolism,
cell
death,
ion
pump
function,
and
inflammatory
response.
In
recent
years,
there
has
been
significant
interest
in
membrane-functionalized
biomimetic
nanoparticles
as
novel
therapeutic
approach.
This
review
comprehensively
explores
the
mechanisms
importance
of
using
these
to
treat
acute
ischemic
with
special
emphasis
on
their
potential
for
actively
targeting
therapies
through
membranes.
We
provide
an
overview
pathophysiology
present
advances
study
nanoparticles,
emphasizing
drug
delivery
precision-targeted
therapy.
paper
focuses
bio-nanoparticles
encapsulated
bionic
membranes
target
treatment.
It
highlights
mechanism
action
research
progress
regarding
different
types
bi-onic
such
erythrocytes,
neutrophils,
platelets,
exosomes,
macrophages,
neural
stem
cells
treating
while
improve
tissue's
state
attenuate
damage
dysfunction.
Through
in-depth
exploration
benefits
provided
by
reducing
injury
dysfunction,
this
also
provides
comprehensive
cells'
along
that
ameliorate
However,
it
undeniable
are
still
some
challenges
limitations
terms
biocompatibility,
safety,
practical
applications
clinical
translation.
Pharmaceutics,
Год журнала:
2024,
Номер
16(7), С. 849 - 849
Опубликована: Июнь 22, 2024
The
state
of
well-being
and
health
our
body
is
regulated
by
the
fine
osmotic
biochemical
balance
established
between
cells
different
tissues,
organs,
systems.
Specific
districts
human
are
defined,
kept
in
correct
functioning,
and,
therefore,
protected
from
exogenous
or
endogenous
insults
both
mechanical,
physical,
biological
nature
presence
barrier
In
addition
to
placental
barrier,
which
even
acts
as
a
linker
two
organisms,
mother
fetus,
all
barriers,
including
blood-brain
(BBB),
blood-retinal
blood-nerve
blood-lymph
blood-cerebrospinal
fluid
operate
maintain
physiological
homeostasis
within
tissues
organs.
From
pharmaceutical
point
view,
most
challenging
undoubtedly
BBB,
since
its
notably
complicates
treatment
brain
disorders.
BBB
action
can
impair
delivery
chemical
drugs
biopharmaceuticals
into
brain,
reducing
their
therapeutic
efficacy
and/or
increasing
unwanted
bioaccumulation
surrounding
healthy
tissues.
Recent
nanotechnological
innovation
provides
advanced
biomaterials
ad
hoc
customized
engineering
functionalization
methods
able
assist
brain-targeted
drug
delivery.
this
context,
lipid
nanocarriers,
synthetic
(liposomes,
solid
nanoparticles,
nanoemulsions,
nanostructured
carriers,
niosomes,
proniosomes,
cubosomes)
cell-derived
ones
(extracellular
vesicles
cell
membrane-derived
nanocarriers),
considered
one
successful
systems
due
reasonable
biocompatibility
ability
cross
BBB.
This
review
aims
provide
complete
up-to-date
view
on
varied
whether
FDA-approved,
involved
clinical
trials,
used
vitro
vivo
studies,
for
inflammatory,
cancerous,
infectious
diseases.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2071 - 2071
Опубликована: Фев. 27, 2025
Nanoplastics
(NPs)
represent
a
major
challenge
in
environmental
contamination
resulting
from
the
physical,
chemical,
and
biological
degradation
of
plastics.
Their
characterization
requires
advanced
expensive
methods,
which
limit
routine
analyses.
The
effects
NPs
depend
on
their
chemical
physical
properties,
influence
toxicity
interactions
with
systems.
Studies
animal
models,
such
as
Daphnia
magna
Danio
rerio,
show
that
induce
oxidative
stress,
inflammation,
DNA
damage,
metabolic
alterations,
often
related
to
charge
particle
size.
affect
endocrine
functions
by
acting
disruptors,
interfering
thyroid
sex
hormones
showing
potential
transgenerational
through
epigenetic
modifications,
including
hyper-
hypomethylation.
Behavioral
neurofunctional
alterations
have
been
observed
rerio
mouse
suggesting
link
between
NP
exposure
neurotransmitters
dopamine
serotonin.
Despite
limited
human
studies,
presence
breast
milk
placenta
underscores
need
for
further
investigation
health
effects.
Research
focusing
genetic
markers
is
encouraged
elucidate
molecular
mechanisms
risks
associated
chronic
exposure.
