Biomaterials, Год журнала: 2025, Номер unknown, С. 123125 - 123125
Опубликована: Янв. 1, 2025
Язык: Английский
Smart Materials in Medicine, Год журнала: 2024, Номер 5(2), С. 291 - 320
Опубликована: Март 24, 2024
Язык: Английский
Процитировано
10
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Июнь 10, 2024
Abstract Oxidative damage, exacerbated by the excessive accumulation of reactive oxygen species (ROS), profoundly inhibits both crop growth and yield. Herein, a biocompatible nanozyme, calcium hexacyanoferrate nanoparticles (CaHCF NPs), targeting ROS is developed, to mitigate oxidative damage sequestrate heavy metal ions during plant growth. Uniquely, CaHCF NPs feature multifaced enzyme‐like activities, involving superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione peroxidase, thiol ascorbate which enable them neutralize ROS. Furthermore, promote calcium‐cadmium exchange process, diminishing uptake metals. Importantly, 120 µg mL −1 alleviate inhibitory effects hydrogen peroxide cadmium chloride on Arabidopsis tomato. The activities SOD, POD, CAT increase 46.2%, 74.4%, 48.3%, respectively, meanwhile level rises 72.4% in under stress. Moreover, boost expression genes associated with antioxidation, detoxification, nutrient transport, stress resistance. These findings unveil significant potential nanoplatforms equipped nanozymes alleviating plants, not only regulate but also substantially ameliorate yield quality, heralding new era agricultural nanotechnology.
Язык: Английский
Процитировано
10
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 26, 2025
Abstract Immune checkpoint blockade (ICB) therapy has achieved remarkable benefits in the treatment of malignant tumors, but clinical response rates are unsatisfied due to low tumor immunogenicity and abundant immunosuppressive cells. Herein, a plasma membrane targeted photodynamic nanoagonist (designated as PMTPN) is developed potentiate ICB by initiating cell pyroptosis depleting infiltrating B PMTPN composed rationally designed chimeric peptide sequence loaded with Bruton's tyrosine kinase inhibitor (Ibrutinib). Notably, capable sequentially targeting trigger immunogenic cause overwhelming release cytokines, promoting dendritic cells maturation, cytotoxic T lymphocytes (CTLs) activation. Meanwhile, can also deplete reduce secretion interleukin‐10 decrease regulatory enhance CTLs infiltration. Beneficially, synergistic immune modulating characteristics simultaneously eliminate primary distant tumors. This study offers promising strategy elevate immunotherapeutic rate consideration complex factors.
Язык: Английский
Процитировано
1
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Март 7, 2025
Dual-atom nanozymes (DAzymes) have garnered considerable attention as catalysts for reactive oxygen species (ROS)-based therapies, effectively leveraging ROS generation within the tumor microenvironment (TME). Herein, we introduce FeMn-NCe DAzymes, which are meticulously engineered enhanced peroxidase (POD)-mimetic activity and potent radiosensitization to advance radioimmunotherapy. Density functional theory (DFT) calculations reveal that DAzymes lower energy barrier increase substrate affinity, enabling highly efficient catalytic performance. Within TME, these efficiently convert overexpressed hydrogen peroxide (H2O2) into hydroxyl radicals (•OH), potentially activating cGAS-STING immune pathway. This POD-mimetic catalysis is further accelerated under X-ray irradiation, significantly enhancing radiosensitization. Additionally, a uniform coating of ultrasmall gold nanoparticles on enhances absorption cancer cells. The incorporation STING agonist diABZI onto induces long-term antitumor immunity, reprograms immunosuppressive suppresses growth metastasis following single low-dose treatment. work highlights valuable strategy designing radiodynamic immunotherapy.
Язык: Английский
Процитировано
1
Talanta, Год журнала: 2025, Номер 292, С. 127941 - 127941
Опубликована: Март 13, 2025
Язык: Английский
Процитировано
1
Advanced Biology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 9, 2025
Abstract Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, witnessed continuous discovery an increasing number regulatory mechanisms. Trace metal elements play a multifaceted and crucial role in oncology. Interestingly, it been increasingly evident these elements, such copper, are involved regulation iron accumulation, lipid peroxidation antiferroptotic systems, suggesting existence “nonferrous” mechanisms ferroptosis. In this review, comprehensive overview composition mechanism ferroptosis is provided. The interaction between copper metabolism (including cuproptosis) cancer, well roles other trace (such zinc, manganese, cobalt, molybdenum) specifically focused. Furthermore, applications nanomaterials based on metals cancer therapy also reviewed potential strategies for co‐targeting cuproptosis explored. Nevertheless, light intricate ambiguous nature interactions, ongoing research essential to further elucidate ferroptosis, thereby facilitating development therapeutic targets approaches treatment.
Язык: Английский
Процитировано
1
Advanced Functional Materials, Год журнала: 2024, Номер 34(46)
Опубликована: Июнь 10, 2024
Abstract Immunotherapy, one of the most promising antitumor strategies, is used to treat prostate cancer (PCa). However, owing immunosuppressive tumor microenvironment (TME), therapeutic effect immune response greatly weakened. Therefore, there an urgent need explore new methods enhance responses. In this study, a single‐atom nanozyme platform (Cu SA‐DOX@COD) that can trigger pyroptosis developed activate responses via gasdermin E (GSDME)‐dependent pathway. It triggered by catalyzing production reactive oxygen species (ROS) and depleting reduced glutathione through intrinsic multi‐enzyme simulated activities providing source for cholesterol (CHOL) oxidation. Meanwhile, loaded CHOL oxidase not only reduces content cells increase cell membrane permeability inhibit proliferation invasion but also oxidizes increases level H 2 O in pyroptosis. addition, doxorubicin activated caspase‐3 cleave GSDME further augment Consequently, Cu SA‐DOX@COD enhances immunocompetence reshapes TME triggering caused ROS storm, chemotherapy, CHOL, thereby activating systemic immunity PCa.
Язык: Английский
Процитировано
7
Journal of Colloid and Interface Science, Год журнала: 2025, Номер 685, С. 753 - 765
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
1
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 21, 2025
Abstract Remodeling of the tumor immune microenvironment and enhancement antitumor responses are necessary to overcome immunotherapy resistance in tumors. However, heterogeneity complexity evasion mechanisms pose significant therapeutic challenges. Nanozymes exhibit enzyme‐like characteristics unique nanomaterial properties, showing potential for therapy. design effective nanozymes remains complex, inefficient, functionally limited. Therefore, this study, a novel strategy combining rationally designed single‐atom (SAzymes) with checkpoint blockade (ICB) therapy is established. Molybdenum SAzymes supported on graphitic carbon nitride (Mo SAs) constructed using 25 transition metal candidates from 4th 6th periods based high‐throughput calculations optimal piezoelectric‐enhanced multienzyme‐like activities. Upon activation by ultrasound, Mo SAs exerted potent effects against ICB‐resistant tumors remodeled inducing immunogenic cell death, alleviating hypoxia, modulating chemokine expression Combination anti‐programmed death protein‐1 antibodies further enhanced their efficacy, highlighting treat
Язык: Английский
Процитировано
1
Biomaterials Research, Год журнала: 2025, Номер 29
Опубликована: Янв. 1, 2025
Tumors are the second most common cause of mortality globally, ranking just below heart disease. With continuous advances in diagnostic technology and treatment approaches, survival rates some cancers have increased. Nevertheless, due to complexity mechanisms underlying tumors, cancer remains a serious public health issue that threatens population globally. Manganese (Mn) is an essential trace element for human body. Its regulatory role tumor biology has received much attention recent years. Developments nanotechnology led emergence Mn-based nanoparticles great potential use diagnosis cancers. nanomaterials can be integrated with conventional techniques, including chemotherapy, radiation therapy, gene augment their therapeutic effectiveness. Further, play synergistic emerging strategies such as immunotherapy, photothermal photodynamic electromagnetic hyperthermia, sonodynamic chemodynamic intervention therapy. Moreover, enhance both precision diagnostics capability combined treatment. This article examines roles associated Mn field physiology biology, focus on application prospects
Язык: Английский
Процитировано
1