Abstract
Altered
redox
homeostasis
has
long
been
observed
in
cancer
cells,
which
can
be
exploited
for
therapeutic
benefits.
However,
reactive
oxygen
species
(ROS)
pleiotropy
coupling
with
reductive
adaptation
cells
poses
a
formidable
challenge
dyshomeostasis‐based
therapy.
Herein,
AuPd
alloying
nanozyme‐glutathione
(GSH)
biosynthesis
inhibitor
co‐delivery
system
(B‐BMES)
is
developed
using
dendritic
SiO
2
as
matrix
to
target
homeostasis.
By
optimizing
element
composition,
the
nanozyme
B‐BMES
exhibits
potent
peroxidase
(POD)‐like
activity
trigger
ROS
insults‐mediated
dyshomeostasis.
Such
POD
functionality
attributed
optimized
electronic
structure
and
catalytic
activity.
Simultaneously,
abrogates
by
exerting
its
molecule‐targeted
GSH
suppression,
thereby
achieving
dual‐disruption
on
Camouflaging
tumor‐homologous
cytomembrane,
hybrid
nanosystem
biological
stability
tumor‐targeting
ability
further
fabricated,
initiates
safe,
precise
disruption‐based
therapy
sensibilizes
standard
chemotherapy.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Abstract
The
global
crisis
of
bacterial
infections
is
exacerbated
by
the
escalating
threat
microbial
antibiotic
resistance.
Nanozymes
promise
to
provide
ingenious
solutions.
Here,
we
reported
a
homogeneous
catalytic
structure
Pt
nanoclusters
with
finely
tuned
metal–organic
framework
(ZIF‐8)
channel
structures
for
treatment
infected
wounds.
Catalytic
site
normalization
showed
that
active
aggregates
fine‐tuned
pore
modifications
had
capacity
14.903×10
5
min
−1
,
which
was
18.7
times
higher
than
particles
in
monodisperse
state
ZIF‐8
(0.793×10
).
In
situ
tests
revealed
change
from
homocleavage
heterocleavage
hydrogen
peroxide
at
interface
nanozyme
one
key
reasons
improvement
activity.
Density‐functional
theory
and
kinetic
simulations
reaction
jointly
determine
role
center
substrate
together.
Metabolomics
analysis
developed
nanozyme,
working
conjunction
reactive
oxygen
species,
could
effectively
block
energy
metabolic
pathways
within
bacteria,
leading
spontaneous
apoptosis
rupture.
This
pioneering
study
elucidates
new
ideas
regulation
artificial
enzyme
activity
provides
perspectives
development
efficient
substitutes.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Окт. 8, 2024
Pyroptosis,
an
immunogenic
programmed
cell
death,
could
efficiently
activate
tumor
immunogenicity
and
reprogram
immunosuppressive
microenvironment
for
boosting
cancer
immunotherapy.
However,
the
overexpression
of
SLC7A11
promotes
glutathione
biosynthesis
maintaining
redox
balance
countering
pyroptosis.
Herein,
we
develop
intermetallics
modified
with
glucose
oxidase
(GOx)
soybean
phospholipid
(SP)
as
pyroptosis
promoters
(Pd
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Nanozymes
have
shown
significant
potential
in
cancer
catalytic
therapy
by
strategically
catalyzing
tumor-associated
substances
and
metabolites
into
toxic
reactive
oxygen
species
(ROS)
situ,
thereby
inducing
oxidative
stress
promoting
cell
death.
However,
within
the
complex
tumor
microenvironment
(TME),
rational
design
of
nanozymes
factors
like
activity,
reaction
substrates,
TME
itself
significantly
influence
efficiency
ROS
generation.
To
address
these
limitations,
recent
research
has
focused
on
exploring
that
affect
activity
developing
nanozyme-based
cascade
systems,
which
can
trigger
two
or
more
processes
tumors,
producing
therapeutic
achieving
efficient
stable
with
minimal
side
effects.
This
area
remarkable
progress.
Perspective
provides
a
comprehensive
overview
nanozymes,
covering
their
classification
fundamentals.
The
regulation
nanozyme
strategies
are
discussed
detail.
Furthermore,
representative
paradigms
for
successful
construction
systems
treatment
summarized
focus
revealing
underlying
mechanisms.
Finally,
we
current
challenges
future
prospects
development
biomedical
applications.
Abstract
Complexity
of
tumor
and
its
microenvironment
as
obstacles
often
restrict
traditional
therapies.
Enzyme/nanozyme‐mediated
catalytic
therapy
has
been
emerged,
but
the
efficacy
single
is
still
moderate.
Inspired
by
concepts
synergetic
therapy,
an
enzyme‐nanozyme
cascade
catalysis
(ENCAT)‐enhanced
developed.
First,
metal–organic
framework
(MOF)
PCN222‐Mn
(PM)
glucose
oxidase
(GOx)
are
chosen
nanozyme
natural
enzyme,
respectively.
Then
two
assembled
together
to
form
complex
PCN222‐Mn@GOx
(PMG).
To
achieve
targeting
GOx
protection,
hyaluronic
acid
(HA)
modified
on
PMG
obtain
PCN222‐Mn@GOx/HA
(PMGH).
Both
cellular
animal
studies
demonstrate
a
catalysis‐enhanced
PMGH.
Specifically,
PDT
achieved
based
mediated
cascade‐catalyzed
O
2
generation;
enhanced
synergistic
demonstrated
combining
PM‐mediated
PDT,
GOx‐mediated
starvation
activated/promoted
immunotherapy
together.
Additionally,
designed
explored
in
bearing
mouse
model,
where
it
exhibits
powerful
anti‐tumor
effects
against
both
primary
metastatic
tumors.
This
strategy
potential
broaden
therapeutic
approaches.
Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 7, 2025
In
recent
10
years,
ferroptosis
has
become
a
hot
research
direction
in
the
scientific
community
as
new
way
of
cell
death.
Iron
toxicity
accumulation
and
lipotoxicity
are
unique
features.
Several
studies
have
found
that
is
involved
regulation
hepatic
microenvironment
various
metabolisms,
thereby
mediating
progression
related
liver
diseases.
For
example,
NRF2
FSP1,
important
regulatory
proteins
ferroptosis,
development
tumors
failure.
this
manuscript,
we
present
mechanisms
concern
with
addition,
summarize
clinical
advances
targeted
therapy
for
We
expect
manuscript
can
provide
perspective
treatment
Despite
the
advantages
of
high
tissue
penetration
depth,
selectivity,
and
non-invasiveness
photothermal
therapy
for
cancer
treatment,
developing
NIR-II
agents
with
desirable
performance
advanced
theranostics
ability
remains
a
key
challenge.
Herein,
universal
surface
modification
strategy
is
proposed
to
effectively
improve
vanadium
carbide
MXene
nanosheets
(L-V
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
Nanozymes,
nanomaterials
with
intrinsic
enzyme
activity,
have
garnered
significant
attention
in
recent
years
due
to
their
catalytic
abilities
comparable
natural
enzymes,
cost-effectiveness,
high
activities,
and
stability
against
environmental
fluctuations.
As
functional
analogs
of
nanozymes
participate
various
critical
metabolic
processes,
including
glucose
metabolism,
lactate
the
maintenance
redox
homeostasis,
all
which
are
essential
for
normal
cellular
functions.
However,
disruptions
these
pathways
frequently
promote
tumorigenesis
progression,
making
them
potential
therapeutic
targets.
While
several
therapies
targeting
tumor
metabolism
currently
clinical
or
preclinical
stages,
efficacy
requires
further
enhancement.
Consequently,
that
target
regarded
as
a
promising
strategy.
Despite
extensive
studies
investigating
application
relevant
reviews
relatively
scarce.
This
article
first
introduces
physicochemical
properties
biological
behaviors
nanozymes.
Subsequently,
we
analyze
role
explore
applications
therapy.
In
conclusion,
this
review
aims
foster
innovative
research
related
fields
advance
development
nanozyme-based
strategies
cancer
diagnostics
therapeutics.
