Tailored Metal‐Organic Framework‐Based Nanozymes for Enhanced Enzyme‐Like Catalysis

Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

Abstract The global crisis of bacterial infections is exacerbated by the escalating threat microbial antibiotic resistance. Nanozymes promise to provide ingenious solutions. Here, we reported a homogeneous catalytic structure Pt nanoclusters with finely tuned metal–organic framework (ZIF‐8) channel structures for treatment infected wounds. Catalytic site normalization showed that active aggregates fine‐tuned pore modifications had capacity 14.903×10 5 min −1 , which was 18.7 times higher than particles in monodisperse state ZIF‐8 (0.793×10 ). In situ tests revealed change from homocleavage heterocleavage hydrogen peroxide at interface nanozyme one key reasons improvement activity. Density‐functional theory and kinetic simulations reaction jointly determine role center substrate together. Metabolomics analysis developed nanozyme, working conjunction reactive oxygen species, could effectively block energy metabolic pathways within bacteria, leading spontaneous apoptosis rupture. This pioneering study elucidates new ideas regulation artificial enzyme activity provides perspectives development efficient substitutes.

Язык: Английский

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Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Язык: Английский

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Intermetallics triggering pyroptosis and disulfidptosis in cancer cells promote anti-tumor immunity

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 8, 2024

Pyroptosis, an immunogenic programmed cell death, could efficiently activate tumor immunogenicity and reprogram immunosuppressive microenvironment for boosting cancer immunotherapy. However, the overexpression of SLC7A11 promotes glutathione biosynthesis maintaining redox balance countering pyroptosis. Herein, we develop intermetallics modified with glucose oxidase (GOx) soybean phospholipid (SP) as pyroptosis promoters (Pd

Язык: Английский

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Surface Engineering Enhances Vanadium Carbide MXene‐Based Nanoplatform Triggered by NIR‐II for Cancer Theranostics

Small, Год журнала: 2024, Номер 20(44)

Опубликована: Июль 5, 2024

Despite the advantages of high tissue penetration depth, selectivity, and non-invasiveness photothermal therapy for cancer treatment, developing NIR-II agents with desirable performance advanced theranostics ability remains a key challenge. Herein, universal surface modification strategy is proposed to effectively improve vanadium carbide MXene nanosheets (L-V

Язык: Английский

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From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Март 7, 2025

In recent 10 years, ferroptosis has become a hot research direction in the scientific community as new way of cell death. Iron toxicity accumulation and lipotoxicity are unique features. Several studies have found that is involved regulation hepatic microenvironment various metabolisms, thereby mediating progression related liver diseases. For example, NRF2 FSP1, important regulatory proteins ferroptosis, development tumors failure. this manuscript, we present mechanisms concern with addition, summarize clinical advances targeted therapy for We expect manuscript can provide perspective treatment

Язык: Английский

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A Powerful Tumor Catalytic Therapy by an Enzyme‐Nanozyme Cascade Catalysis (ENCAT) System

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Abstract Complexity of tumor and its microenvironment as obstacles often restrict traditional therapies. Enzyme/nanozyme‐mediated catalytic therapy has been emerged, but the efficacy single is still moderate. Inspired by concepts synergetic therapy, an enzyme‐nanozyme cascade catalysis (ENCAT)‐enhanced developed. First, metal–organic framework (MOF) PCN222‐Mn (PM) glucose oxidase (GOx) are chosen nanozyme natural enzyme, respectively. Then two assembled together to form complex PCN222‐Mn@GOx (PMG). To achieve targeting GOx protection, hyaluronic acid (HA) modified on PMG obtain PCN222‐Mn@GOx/HA (PMGH). Both cellular animal studies demonstrate a catalysis‐enhanced PMGH. Specifically, PDT achieved based mediated cascade‐catalyzed O 2 generation; enhanced synergistic demonstrated combining PM‐mediated PDT, GOx‐mediated starvation activated/promoted immunotherapy together. Additionally, designed explored in bearing mouse model, where it exhibits powerful anti‐tumor effects against both primary metastatic tumors. This strategy potential broaden therapeutic approaches.

Язык: Английский

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Emerging Roles of Nanozyme in Tumor Metabolism Regulation: Mechanisms, Applications, and Future Directions

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Nanozymes, nanomaterials with intrinsic enzyme activity, have garnered significant attention in recent years due to their catalytic abilities comparable natural enzymes, cost-effectiveness, high activities, and stability against environmental fluctuations. As functional analogs of nanozymes participate various critical metabolic processes, including glucose metabolism, lactate the maintenance redox homeostasis, all which are essential for normal cellular functions. However, disruptions these pathways frequently promote tumorigenesis progression, making them potential therapeutic targets. While several therapies targeting tumor metabolism currently clinical or preclinical stages, efficacy requires further enhancement. Consequently, that target regarded as a promising strategy. Despite extensive studies investigating application relevant reviews relatively scarce. This article first introduces physicochemical properties biological behaviors nanozymes. Subsequently, we analyze role explore applications therapy. In conclusion, this review aims foster innovative research related fields advance development nanozyme-based strategies cancer diagnostics therapeutics.

Язык: Английский

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Arsenene-Vanadene Nanodots Co-Activate Apoptosis/Ferroptosis for Enhanced Chemo-Immunotherapy

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis

Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 137337 - 137337

Опубликована: Март 1, 2025

Язык: Английский

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Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Abstract Poor prognosis and chemotherapy response stem from difficulties in precise targeting the lack of effective synergistic treatments. Nanozymes show promising potential tumor chemodynamic therapy (CDT) by catalyzing hydrogen peroxide (H₂O₂) decomposition glutathione depletion microenvironment (TME). However, integrating with CDT remains challenging. In this study, a porous Fe/Cu bimetallic nanozyme carrier (FeCuNPs) is developed for co‐loading humanized 3F8 anti‐GD2 disialoganglioside antibody (3F8) novel pyridazinone‐based chemotherapeutic agent (IMB), forming nanoreactor (3F8@FeCuNPs@IMB) targeted CDT. The responds specifically to acidic TME as primary insurance, allowing controlled release IMB at site. coating on surface acts secondary minimizing drug leakage during delivery process ensuring chemotherapy. Furthermore, FeCuNPs act peroxidase‐like (POD) oxidase‐like (GSHOX) enzymes, hydroxyl radical (•OH) generation depleting excess GSH, enhancing results vitro vivo indicate that dual insurance designed 3F8@FeCuNPs@IMB offers prospect targeted, precise, combination against melanoma.

Язык: Английский

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