ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Hydrogel
wound
dressings
have
emerged
as
a
promising
solution
for
healing
due
to
their
excellent
mechanical
and
biochemical
properties.
Over
recent
years,
there
has
been
significant
progress
in
expanding
the
variety
of
raw
materials
used
hydrogel
formulation
along
with
development
advanced
modification
techniques
design
approaches
that
enhance
performance.
However,
comprehensive
review
encompassing
diverse
polymer
strategies
innovations
is
still
lacking
literature.
This
summarizes
use
natural
polymers
(e.g.,
chitosan,
gelatin,
sodium
alginate,
hyaluronic
acid,
dextran)
synthetic
poly(vinyl
alcohol),
polyethylene
glycol,
Pluronic
F-127,
poly(N-isopropylacrylamide),
polyacrylamide,
polypeptides)
dressings.
We
further
explore
advantages
limitations
these
discuss
various
strategies,
including
cationic
modification,
oxidative
double-bond
catechol
etc.
The
also
addresses
principles
synthesis
methods,
aligning
modifications
specific
requirements
healing.
Finally,
we
future
challenges
opportunities
hydrogel-based
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июль 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(13), С. 3171 - 3190
Опубликована: Янв. 1, 2024
This
review
summarizes
fabrication
strategies
and
manifold
applications
of
electrospun
organic/inorganic
hybrid
nanofibers
in
promoting
the
wound
healing
process.
Advanced Materials,
Год журнала:
2024,
Номер
36(41)
Опубликована: Авг. 16, 2024
Hydrogel
bioadhesives
have
emerged
as
a
promising
alternative
to
wound
dressings
for
chronic
management.
However,
many
existing
do
not
meet
the
functional
requirements
efficient
management
through
dynamically
mechanical
modulation,
due
reduced
contractibility,
frequent
recurrence,
incapability
actively
adapt
external
microenvironment
variation,
especially
those
gradually-expanded
wounds.
Here,
self-growing
hydrogel
bioadhesive
(sGHB)
patch
that
exhibits
instant
adhesion
biological
tissues
but
also
gradual
increase
in
strength
and
interfacial
adhesive
within
120-h
application
is
presented.
The
gradually
increased
mechanics
of
sGHB
could
effectively
mitigate
stress
concentration
at
edge,
resist
expansion
various
stages,
thus
mechanically
contracting
wounds
programmable
manner.
demonstrated
enhanced
healing
efficacy
mouse
diabetic
model,
by
regulating
inflammatory
response,
promoting
faster
re-epithelialization
angiogenesis
modulation.
Such
kind
potential
clinical
utility
variety
where
dynamic
modulation
indispensable.
Despite
significant
progress
in
skin
wound
healing,
it
is
still
a
challenge
to
construct
multifunctional
bioactive
dressings
based
on
highly
aligned
protein
fiber
coated
hydrogel
matrix
for
antifibrosis
regeneration
that
indistinguishable
native
skin.
In
this
study,
"dual-wheel-driven"
strategy
adopted
modify
the
surface
of
methacrylated
gelatin
(GelMA)
with
magnetic
nanocomposites-protein
assemblies
(MPF)
consisting
photothermal
responsive
antibacteria
superparamagnetic
nanocomposites-fibrinogen
(Fg)
complexes
as
building
blocks.
Whole-phase
healing
properties
modified
dressing,
GelMA-MPF
(GMPF),
stem
from
integration
Fg
RGD
peptide
activity
decorated
antibacterial
nanoactuator,
facilitating
facile
and
reproducible
dressing
preparation
by
self-assembly
involving
biochemical,
morphological,
biophysical
cues.
Payload
substantial
release
copper
ions
Inadequate
vascularization
significantly
hampers
wound
recovery
by
limiting
nutrient
delivery.
To
address
this
challenge,
we
extracted
membrane
vesicles
from
Lactobacillus
reuteri
(LMVs)
and
identified
their
angiogenic
potential
via
transcriptomic
analysis.
We
further
developed
a
composite
hydrogel
system
(Gel-LMVs)
anchoring
LMVs
within
carboxylated
chitosan
cross-linking
it
with
oxidized
hyaluronic
acid
through
Schiff
base
reaction.
The
resulting
Gel-LMVs
exhibit
good
biocompatibility
retain
the
bioactivity
of
LMVs,
which
are
released
in
controlled
manner
to
stimulate
cell
proliferation,
migration,
angiogenesis
vitro
modulating
gene
expression
critical
signaling
pathways.
Moreover,
an
vivo
model,
upregulate
vascular
endothelial
growth
factor
(VEGF)
platelet
adhesion
molecule
(CD31),
leading
accelerated
early
healing
stages,
while
concurrently
reducing
inflammation
augmenting
collagen
deposition
enhance
quality.
This
approach
functionalizing
biomaterials
probiotic-MVs
offers
advanced
strategy
for
healing.
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
Oral
ulcer
wounds
are
difficult
to
heal
due
bacterial
infections,
persistent
inflammatory
responses,
and
excessive
reactive
oxygen
species
(ROS).
Therefore,
the
elimination
of
bacteria,
removal
ROS,
reduction
inflammation
prerequisites
for
treatment
mouth
wounds.
In
this
study,
oligomeric
proanthocyanidins
(OPC)
3-(aminomethyl)phenylboronic
acid-modified
hyaluronic
acid
(HP)
were
used
form
polymer
gels
through
dynamic
covalent
borate
bonds.
Minocycline
hydrochloride
(MH)
was
then
loaded
into
gel,
a
multifunctional
MH/OPC-HP
microneedles
(MNs)
with
ROS-responsive
properties
prepared
using
vacuum
method.
The
MNs
can
rapidly
release
MH
in
diffusive
manner
sustainably
OPC
response
ROS.
gel-based
extended
retention
oral
ulcers,
leading
prolonged
ROS
scavenging
effects.
Cytocompatibility
hemocompatibility
tests
showed
that
had
good
biocompatibility.
Antibacterial
experiments
demonstrated
exhibited
excellent
antibacterial
vitro
indicated
could
effectively
clear
reduce
oxidative
stress
damage,
inhibit
M1-type
macrophage
polarization,
induce
M2-type
polarization.
Furthermore,
vivo
revealed
pro-inflammatory
cytokines,
promote
neovascularization,
accelerate
epithelial
healing
significantly
rat
model
wound
infection.
summary,
hold
promise
as
therapeutic
strategy
enhancing
