Collagen-Based Nanoparticles as Drug Delivery System in Wound Healing Applications
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 11321 - 11341
Опубликована: Ноя. 1, 2024
Background:
Conventional
wound
dressings
often
adhere
to
wounds
and
can
cause
secondary
injury
due
their
lack
of
anti-inflammatory
antibacterial
properties.
In
contrast,
collagen-based
nanoparticles
(NPs)
as
drug
delivery
systems
exhibit
both
biocompatibility
biodegradability,
presenting
a
promising
avenue
for
accelerating
healing
processes.
Aims
Study:
This
review
aims
provide
comprehensive
overview
the
mechanisms
involved
in
healing,
description
attributes
ideal
dressings,
understanding
efficacy
collagen,
exploring
NPs-mediated
therapy,
detailing
synthesis
fabrication
techniques
NPs,
delineating
applications
various
NPs
infused
on
healing.
Methodology:
synthesizes
relevant
literature
from
reputable
databases
such
Scopus,
Science
Direct,
Google
Scholar,
PubMed.
Results:
A
diverse
array
including
nanopolymers,
metal
nanoemulsions,
nanoliposomes,
nanofibers,
demonstrate
pronounced
promoting
closure
tissue
regeneration.
The
incorporation
has
not
only
become
an
agent
therapeutics
but
also
actively
contributes
cascade.
Conclusion:
conclusion,
brief,
use
presents
compelling
strategy
expediting
Keywords:
nanoparticles,
techniques,
collagen
Язык: Английский
Biomineralized Nanocomposite‐Integrated Microneedle Patch for Combined Brachytherapy and Photothermal Therapy in Postoperative Melanoma Recurrence and Infectious Wound Healing
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
Abstract
In
the
surgical
management
of
malignant
melanoma,
incomplete
tumor
resection
and
large‐area
cutaneous
defects
are
major
contributors
to
high
locoregional
recurrence
uncontrolled
wound
infections,
resulting
in
poor
prognosis
prolonged
recovery
times
for
patients.
Herein,
a
versatile
nanocomposite
microneedle
patch
(referred
as
GM‐Ag
2
S/Ca
32
P)
is
designed
simultaneously
eliminate
residual
post‐surgery
promote
healing
infectious
wounds.
This
effectively
penetrates
subcutaneous
tissues,
delivering
therapeutic
payloads
infiltrating
cells
bacteria.
The
Ag
P
nanocomposites
encapsulated
within
decompose
acidic
microenvironment
tumors
bacterial
biofilms,
releasing
radioactive
S
nanodots,
which
enhance
eradication
bacteria
killing
through
synergistic
brachytherapy
photothermal
therapy
(PTT).
Moreover,
promotes
scar‐free
by
reducing
inflammation,
promoting
granulation
tissue
formation,
collagen
deposition,
angiogenesis,
thanks
localized
hyperthermia,
radiation,
swelling
biodegradation
matrices.
patch‐based
postoperative
adjuvant
offers
comprehensive
strategy
addressing
melanoma
healing,
with
promising
potential
clinical
application
postsurgical
management.
Язык: Английский
Research Progress on the Preparation and Application of Decellularized Tendons
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(4), С. 251 - 251
Опубликована: Апрель 6, 2025
Tendons
connect
animal
skeletons
to
skeletal
muscles,
playing
a
crucial
role
in
weight-bearing
and
maintaining
motor
functions.
After
decellularization,
tendon
extracellular
matrix
(tECM)
retains
the
physicochemical
characteristics
similar
those
of
native
tendons.
This
has
made
tECM
promising
biomaterial
fields
tissue
engineering
regenerative
medicine
recent
years.
paper
summarizes
origin,
structure,
ECM
components
tendons,
reviews
decellularization
methods,
discusses
advancements
research
applications
decellularized
Furthermore,
it
explores
future
development
trends
xenogeneic
materials,
aiming
provide
reference
for
fundamental
biomaterials
related
Язык: Английский
Injectable Gypsogenin‐Based Composite Hydrogel Enhances Osteoporotic Bone Regeneration by Alleviating Oxidative Injury via Promoting AMPKα Phosphorylation
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Abstract
Osteoporosis
is
characterized
by
an
imbalance
between
osteoblasts
and
osteoclasts
coupling
excessive
oxidative
stress
in
the
bone
microenvironment
that
impairs
defect
healing
increases
risk
of
non‐union.
In
this
study,
injectable
gypsogenin
(GN)‐based
organic–inorganic
composite
hydrogel
(CCT/nHA@GN)
developed
to
treat
osteoporotic
defects.
The
made
grafting
sodium
citrate
(SC)
nano‐hydroxyapatite
(nHA)/GN
nanoparticles
onto
carboxymethylated
chitosan
(CMCS).
GN
a
natural
small‐molecule
saponin,
which
shows
biocompatibility
anti‐oxidant
properties.
resulting
well‐defined
porous
structure,
favorable
degradability,
controlled
drug‐release
properties,
suitable
rheological
characteristics.
Importantly,
it
reverses
differentiation
fate
marrow‐derived
mesenchymal
stem
cells
(BMSCs)
from
patients
promotes
angiogenesis
human
umbilical
vein
endothelial
(HUVECs).
Furthermore,
activates
AMPKα‐FOXO3a‐CAT/MnSOD
signaling
pathway
via
AMPKα
phosphorylation,
thereby
augmenting
antioxidant
capacity,
promoting
osteogenesis,
inhibiting
osteoclastogenesis,
ultimately
rectifying
disrupted
microenvironment.
vivo
studies
reveal
volume
total
(BV/TV)
ratio
bones
regenerated
with
CCT/nHA@GN
2.85
times
higher
than
control
group.
conclusion,
these
findings
suggest
can
be
promising
alternative
material
for
treatment
Язык: Английский
Isolation of cellulose microfibers from banana plant residues and their conversion into sustainable and biocompatible 3D printable hydrogels for drug delivery
Industrial Crops and Products,
Год журнала:
2025,
Номер
229, С. 120998 - 120998
Опубликована: Апрель 10, 2025
Язык: Английский
Engineering cell-derived extracellular matrix for peripheral nerve regeneration
Materials Today Bio,
Год журнала:
2024,
Номер
27, С. 101125 - 101125
Опубликована: Июнь 13, 2024
Extracellular
matrices
(ECMs)
play
a
key
role
in
nerve
repair
and
are
recognized
as
the
natural
source
of
biomaterials.
In
parallel
to
extensively
studied
tissue-derived
ECMs
(ts-ECMs),
cell-derived
(cd-ECMs)
also
have
capability
partially
recapitulate
complicated
regenerative
microenvironment
native
tissues.
Notably,
cd-ECMs
can
avoid
shortcomings
ts-ECMs.
Cd-ECMs
be
prepared
by
culturing
various
cells
or
even
autologous
vitro
under
pathogen-free
conditions.
And
mild
decellularization
achieve
efficient
removal
immunogenic
components
cd-ECMs.
Moreover,
more
readily
customizable
desired
functional
properties.
These
advantages
garnered
significant
attention
for
potential
neuroregenerative
medicine.
As
promising
biomaterials,
bring
new
hope
effective
treatment
peripheral
injuries.
Herein,
this
review
comprehensively
examines
current
knowledge
about
characteristics
their
mechanisms
interaction
with
regeneration,
particular
focus
on
preparation,
engineering
optimization,
scalability
The
applications
from
distinct
cell
sources
reported
tissue
highlighted
summarized.
Furthermore,
limitations
that
should
addressed
outlooks
related
clinical
translation
put
forward
well.
Язык: Английский
The Biological Macromolecules constructed Matrigel for cultured organoids in biomedical and tissue engineering
Colloids and Surfaces B Biointerfaces,
Год журнала:
2024,
Номер
247, С. 114435 - 114435
Опубликована: Дек. 7, 2024
Язык: Английский
Effect of non‐thermal acidic and alkaline modifications on the structural, pasting, rheological, and functional properties of cassava (Manihot esculenta) starch
Journal of Food Science,
Год журнала:
2024,
Номер
89(10), С. 6601 - 6615
Опубликована: Сен. 17, 2024
This
study
aimed
to
investigate
the
effects
of
acid
or
alkali
modification
isolated
cassava
starch
(ICS)
on
its
physicochemical
properties.
Acetic
concentrations
5%,
10%,
and
20%
v/v
(0.87,
1.73,
3.46
M,
respectively)
calcium
hydroxide
0.15%,
0.20%,
0.30%
w/w
(0.02,
0.025,
0.04
were
tested
independently
compared
with
untreated
starch.
The
scanning
electron
microscope
(SEM)
shows
starches
polyhedral
semispherical
shapes;
these
modifications
do
not
change
surface
granules.
Nanocrystals
orthorhombic
crystal
structure
extracted
from
ICS.
Transmission
microscopy
(TEM)
crystallites
a
size
(two-dimensional)
20
±
5
nm
in
length
10
2
width
reveals
that
this
contains
nanocrystals
structure.
X-ray
patterns
show
are
unaffected
by
acidic
alkaline
treatments.
Ca
Язык: Английский
Optimization of fermentation conditions for microbial transglutaminase production by Streptoverticillium cinnamoneum KKP 1658 using response surface methodology (RSM)
Folia Microbiologica,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 22, 2024
Abstract
Microbial
transglutaminase
(MTG)
is
an
enzyme
widely
used
in
the
food
industry
because
it
creates
cross-links
between
proteins,
enhancing
texture
and
stability
of
products.
Its
unique
properties
make
a
valuable
tool
for
modifying
functional
characteristics
significantly
impacting
quality
innovation
In
this
study,
response
surface
methodology
was
employed
to
optimize
fermentation
conditions
microbial
production
by
strain
Streptoverticillium
cinnamoneum
KKP
1658.
The
effects
nitrogen
dose,
cultivation
time,
initial
pH
on
activity
produced
were
investigated.
significance
examined
factors
determined
as
follows:
time
>
dose
pH.
interaction
found
be
crucial,
having
second
most
significant
impact
activity.
Optimal
identified
48
h
with
2%
source
medium
approximately
6.0.
Under
these
conditions,
ranged
from
4.5
5.5
U/mL.
results
study
demonstrated
that
promising
approach
optimizing
production.
Future
applications
include
development
modern
products
improved
nutritional
value,
well
its
potential
use
regenerative
medicine
creating
biomaterials
tissue
scaffolds.
This
topic
particularly
important
timely
addresses
growing
demand
innovative
sustainable
solutions
biomedical
industries,
contributing
life.
Язык: Английский
A Cell Adhesive Radial Nanofiber Membrane for Promoting Diabetes Wound Healing
ACS Applied Polymer Materials,
Год журнала:
2024,
Номер
7(1), С. 258 - 267
Опубликована: Дек. 27, 2024
Diabetic
wounds
are
extremely
difficult
to
heal
due
the
long
duration
and
high
recurrence
rate.
The
bacterial
infection
caused
by
elevated
blood
glucose
negatively
affects
speed
of
wound
healing.
In
this
article,
radially
oriented
nanofibers
containing
natural
antimicrobial
agent
purslane
were
prepared
electrostatic
spinning.
Subsequently,
asiaticoside
was
loaded
onto
surface
fibers
spraying.
experimental
results
indicated
that
radial
nanofiber
membranes
exhibited
uniform
diameter
distribution,
suitable
water
vapor
permeability,
good
hydrophilicity
as
well
excellent
antibacterial
performance
biocompatibility.
Due
ordered
arrangement,
healing
ability,
regular
granulation
tissue
growth,
collagen
deposition.
More
importantly,
fiber
structure
significantly
promoted
cell
proliferation
adhesion.
Based
on
these
results,
with
a
have
potential
application
prospects
in
field
chronic
diabetic
Язык: Английский