Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 26, 2025
Abstract
Rectal
cancer
surgery
is
challenging
due
to
the
complex
anatomy,
making
it
difficult
achieve
clear
surgical
margins.
Radiotherapy
(RT)
plays
a
crucial
role,
especially
in
treating
locally
recurrent
rectal
and
preserving
anal
function.
However,
its
effectiveness
often
limited
by
tumor
hypoxia,
particularly
prevalent
hypoxic
regions
near
bowel
wall
colorectal
cancer.
Hypoxia
contributes
both
radiation
resistance
apoptosis
resistance,
compromising
RT
outcomes.
To
overcome
hypoxia‐driven
radiotherapy
this
work
designs
engineers
radiotherapy‐sensitizing
bioplatform
for
efficient
RT.
It
combines
lanthanum
oxide
nanoparticles
(La
2
O
3
NPs)
with
cyanobacteria,
which
produces
oxygen
through
photosynthesis.
This
uniquely
reduces
enhances
deposition,
improves
efficacy.
La
NPs
further
enhance
reactive
species
(ROS)
production
induced
radiation,
triggering
pyroptosis
via
ROS‐NLRP3‐GSDMD
pathway,
while
amplifies
GSDME,
circumventing
resistance.
The
integrated
thermosensitive
hydrogels
ensure
precise
localization
of
bioplatform,
reducing
systemic
toxicity
improving
therapeutic
specificity.
Compared
conventional
therapies,
dual‐action
system
addresses
more
effectively.
In
vivo
vitro
hypoxia
models
validate
potent
anti‐tumor
efficacy,
offering
valuable
insights
refining
clinical
treatment
paradigms.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 11633 - 11649
Опубликована: Ноя. 1, 2024
Ischemic
stroke
is
a
medical
emergency
for
which
effective
treatment
remains
inadequate.
Curcumin
(Cur)
natural
polyphenolic
compound
that
regarded
as
potent
neuroprotective
agent.
Compared
to
synthetic
pharmaceuticals,
Cur
possesses
minimal
side
effects
and
exhibits
multiple
mechanisms
of
action,
offering
significant
advantages
in
the
ischemic
stroke.
However,
drawbacks
such
poor
water
solubility
transmembrane
permeability
limit
efficacy
Cur.
In
recent
years,
nano-delivery
systems
have
attracted
great
interest
field
therapy
an
method
improve
drug
cross
blood-brain
barrier
(BBB).
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 6, 2025
Synthetic
biology
and
nanotechnology
fusion
represent
a
transformative
approach
promoting
fundamental
clinical
biomedical
science
development.
In
SynBioNanoDesign,
biological
systems
are
reimagined
as
dynamic
programmable
materials
to
yield
engineered
nanomaterials
with
emerging
specific
functionalities.
This
review
elucidates
comprehensive
examination
of
synthetic
biology's
pivotal
role
in
advancing
for
targeted
drug
delivery
systems.
It
begins
exploring
the
synergy
between
nanotechnology,
then
highlights
current
landscape
applications.
Subsequently,
discusses
design
novel
informed
by
principles,
focusing
on
expounding
tools
potential
developing
advanced
nanomaterials.
Afterward,
research
advances
innovative
through
were
systematically
summarized,
emphasizing
integration
genetic
circuitry
program
nanomaterial
responses.
Furthermore,
challenges,
weaknesses
opportunities,
prospective
directions,
ethical
societal
implications
SynBioNanoDesign
elucidated.
Finally,
summarizes
impact
that
may
have
drug-delivery
technologies
future.
Cerebral
ischemia-reperfusion
injury
(CI/RI)
is
currently
considered
a
significant
factor
affecting
the
prognosis
of
ischemic
stroke.
The
blood-brain
barrier
(BBB)
plays
multiple
roles
in
treatment
ofCI/RI.
BBB
leakage
allows
bloodborne
toxins
to
exacerbate
stroke
pathology.
Yet
as
physiological
that
separates
blood
from
brain,
also
poses
obstacle
therapeutic
drug
delivery.
Therefore,
it
essential
consider
both
crossing
and
repairing
process
CI/RI.
Leveraging
exceptional
benefits
nanoparticles
(NPs)
for
penetration
targeted
repair,
numerous
NPs
are
developed
promising
delivery
platforms.
Considering
complex
role
CI/RI,
this
review
delves
into
strategies
designing
cross
BBB,
focusing
on
peptide-modified
NPs,
cell-mediated
cell
membrane-derived
BBB-modulating
NPs.
Additionally,
summarizes
design
targeting
endothelial
cells
(ECs),
astrocytes,
those
aimed
at
regulating
microenvironment
repair
BBB.
On
basis,
reveals
prospects
challenges
designed
around
CI/RI
treatment.
And
highlights
need
combine
permeability
promotion
nanoparticle
based
achieve
more
effective
Tissue and Cell,
Год журнала:
2025,
Номер
95, С. 102872 - 102872
Опубликована: Март 22, 2025
Neural
stem
cell
therapy
is
considered
as
a
promising
new
for
ischemic
stroke.
However,
the
therapeutic
efficacy
of
neural
cells
(NSCs)
hampered
by
effects
cerebral
ischemia
and
hypoxia,
resulting
in
suboptimal
performance.
Drug
stimulation
can
further
improve
NSCs
stroke,
among
which
small
molecule
peptide
Apelin-13
could
have
potential.
In
this
study,
we
simulated
anoxic
microenvironment
oxygen-glucose
deprivation
(OGD)
to
observe
improvement
on
treatment-related
functions.
Six
hours
OGD
treatment
suppressed
viability
NSCs,
while
100
nM
mitigated
suppression.
Additionally,
reduced
migration
capability
but
enhanced
ability
under
conditions.
also
increased
rate
apoptotic
decreased
ratio
Bcl-2
Bax.
environment,
BDNF
expression
was
elevated,
level.
APJ
endogenous
receptor
Apelin-13.
We
knocked
down
observed
that
effect
abolished
environment
compared
with
negative
control
group
knockdown,
upregulation
brain
derived
neurotrophic
factor
(BDNF)
lost.
Our
study
found
enhances
fosters
migration,
diminishes
apoptosis,
augments
conditions
through
receptor.
The
Apelin-13/APJ
system
may
play
beneficial
role
activating
purpose
treating
This
positive
be
mediated
downstream
effector
protein,
BDNF.
