A DNA tetrahedron-based nanosuit for efficient delivery of amifostine and multi-organ radioprotection

Bioactive Materials, Год журнала: 2024, Номер 39, С. 191 - 205

Опубликована: Май 21, 2024

Unnecessary exposure to ionizing radiation (IR) often causes acute and chronic oxidative damages normal cells organs, leading serious physiological even life-threatening consequences. Amifostine (AMF) is a validated radioprotectant extensively applied in chemotherapy medicine, but the short half-life limits its bioavailability clinical applications, remaining as great challenge be addressed. DNA-assembled nanostructures especially tetrahedral framework nucleic acids (tFNAs) are promising nanocarriers with preeminent biosafety, low biotoxicity, high transport efficiency. The tFNAs also have relative long-term maintenance for structural stability excellent endocytosis capacity. We therefore synthesized tFNA-based delivery system of AMF multi-organ radioprotection (tFNAs@AMF, termed nanosuit). By establishing mice models accidental total body irradiation (TBI) radiotherapy model Lewis lung cancer, we demonstrated that nanosuit could shield from IR-induced DNA damage by regulating molecular biomarkers anti-apoptosis anti-oxidative stress. In model, pretreated exhibited satisfactory alteration superoxide dismutase (SOD) activities malondialdehyde (MDA) contents, functional recovery hematopoietic system, reducing pathological safeguarding lethal radiation. More importantly, showed selective organs without interferences tumor control cancer. Based on conveniently available tetrahedron-based nanocarrier, this work presents high-efficiency prolonged enhanced multi-organs. Such pioneers strategy translation potential radioactivity protection.

Язык: Английский

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Targeting modulation of intestinal flora through oral route by an antimicrobial nucleic acid-loaded exosome-like nanovesicles to improve Parkinson’s disease

Science Bulletin, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Photothermally-enhanced ferroptotic-chemo therapy enabled by ZIF-derived multizyme

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 683, С. 398 - 407

Опубликована: Дек. 14, 2024

Язык: Английский

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Ultrasound-Enhanced Mitochondrial Targeting for Synergistic Mitoxantrone-Based Nanotherapy in Triple-Negative Breast Cancer

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Язык: Английский

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Spatiotemporally Programming Microenvironment to Recapitulate Endochondral Ossification via Greenhouse‐Inspired Bionic Niche

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Abstract Various biomaterials have been developed to address challenging critical‐sized bone defects. However, most of them focus on intramembranous ossification (IMO) rather than endochondral (ECO), often resulting in suboptimal therapeutic outcomes. Drawing inspiration from the functionality greenhouse ecosystem, herein a bionic niche is innovatively crafted recapitulate ECO process. This consists three hierarchical components: an embedded microchannel network that facilitates cell infiltration and matter exchange, polydopamine surface modification layer with immunomodulatory functions, ECO‐targeted delivery system based mesoporous silica nanoparticles. Through spatiotemporally programming microenvironment, effectively recapitulates key stages ECO. Notably, even rat calvaria, region well‐known for IMO, capable initiating ECO, evident by cartilage template formation, leading efficient regeneration. Taken together, this study introduces prospective concepts designing next‐generation ECO‐driven tissue engineering.

Язык: Английский

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Nanotherapeutic platform-mediated cholesterol metabolism regulation for boosting antitumor chemo-immunotherapy

Science China Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Язык: Английский

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Prominent Supramolecular Systems for Cancer Therapy: From Structural Design to Tailored Applications

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117754 - 117754

Опубликована: Май 1, 2025

Язык: Английский

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Multiplex Methionine Modulating Hydrogel for Cancer Metabolic Therapy

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

Abstract The reliance on high levels of methionine by tumor cells provides an attractive target for cancer treatment. However, systemic blockade may raise concerns about potential side effects given the broad and essential functions in cellular metabolism. Here, a combined drug delivery platform multilayered constraint within lesions is developed. Small molecule inhibitors PF9366 adenosine dialdehyde are encapsulated cell‐targeting nanoparticles (NPs) to achieve cascaded blockage intracellular These NPs further co‐loaded with extracellular uptake inhibitor JPH203 into type reactive oxygen species‐sensitive hydrogel, assembling multiplex modulating hydrogel (3 M Gel). In murine models triple‐negative breast (TNBC), hepatocellular carcinoma, colorectal cancer, situ formed 3 Gel exhibits superior efficacy restricting S‐adenosyl generation histone methylation, stimulating immunogenic cell death cells, thereby eliciting potent innate adaptive immune responses restrain progression. Moreover, remodeling microenvironment overcomes checkpoint resistance TNBC. This study presents localized triple regulation strategy paves new path amino acid starvation‐based therapy.

Язык: Английский

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Dual‐Defect Nitrogen‐Rich Carbon Nitride‐Based Heterostructural Nanocatalyst for Improving the Therapeutic Efficacy of αPD‐1 via Tumor Immune Microenvironment Remodelling

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Июнь 4, 2025

Abstract Low immunogenicity, insufficient immune infiltrates, and inhibitive microenvironment of tumors ruthlessly weakened the therapeutic efficacy immunotherapies. How to improve therapy by reshaping tumor still remains a challenge that needs be urgently addressed. Here, novel dual‐defect nitrogen‐rich carbon nitride‐based heterostructural nanocatalyst (CNO@CuMS) possessing brilliant piezocatalytic H 2 O generation, sonocatalytic 1 Fenton‐like catalytic •OH cell cuproptosis inducing properties are developed. Accompanied ultrasonic treatment, immunogenic death (ICD) subsequent releasing damage‐associated molecular patterns (DAMPs) cells successfully triggered CNO@CuMS, which resulted in activation systematic antitumor response enhanced infiltration CD8 + cytotoxic T lymphocytes natural killer (NK) at site. The large quantitatively generated reactive oxygen species (ROS) also promoted polarization M2‐type macrophage M1‐type as well. Benefitting from this remodelling effect, remarkable malignant orthotopic osteosarcoma is achieved employing CNO@CuMS α PD‐1 combination strategy under with no significant side effects observed. This research not only proposes method fabricate high proformance but provides new realize highly efficient bone during clinical practice.

Язык: Английский

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Liposome-like Nanoplatform Regulates Autophagy to Enhance Antitumor Chemo-Immunotherapy

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(22), С. 25447 - 25458

Опубликована: Ноя. 8, 2024

Studies on immunogenic cell death of tumor cells have confirmed that some chemotherapy drugs can induce antitumor immune response. This response is caused by the antigens released dead cells. However, these and damage-associated molecular patterns (DAMPs) be degraded autophagy pathway, which highly upregulated in shown inhibition increase accumulation autophagosomes, reduce degradation major histocompatibility complex (MHC) class I molecules, maintain or even enhance responses. In order to chemotherapy-induced through regulation autophagy, this project intends create a nanoplatform for codelivery chemotherapeutics inhibitors. Phospholipid-modified inhibitor DSPE-BiQ drug DSPE-OXA-PEG were synthesized, respectively, generated system OXA/BiQ-Lip could achieve efficient delivery release EPR effect stimulation from intracellular pH gradient/reduced glutathione concentration changing. The strategy inhibitors not only overcome oxaliplatin resistance but also promote intact autophagosomes containing multiple DAMPs, antigen presentation infiltration, improve triggered chemotherapy.

Язык: Английский

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