A DNA tetrahedron-based nanosuit for efficient delivery of amifostine and multi-organ radioprotection

Bioactive Materials, Journal Year: 2024, Volume and Issue: 39, P. 191 - 205

Published: May 21, 2024

Unnecessary exposure to ionizing radiation (IR) often causes acute and chronic oxidative damages normal cells organs, leading serious physiological even life-threatening consequences. Amifostine (AMF) is a validated radioprotectant extensively applied in chemotherapy medicine, but the short half-life limits its bioavailability clinical applications, remaining as great challenge be addressed. DNA-assembled nanostructures especially tetrahedral framework nucleic acids (tFNAs) are promising nanocarriers with preeminent biosafety, low biotoxicity, high transport efficiency. The tFNAs also have relative long-term maintenance for structural stability excellent endocytosis capacity. We therefore synthesized tFNA-based delivery system of AMF multi-organ radioprotection (tFNAs@AMF, termed nanosuit). By establishing mice models accidental total body irradiation (TBI) radiotherapy model Lewis lung cancer, we demonstrated that nanosuit could shield from IR-induced DNA damage by regulating molecular biomarkers anti-apoptosis anti-oxidative stress. In model, pretreated exhibited satisfactory alteration superoxide dismutase (SOD) activities malondialdehyde (MDA) contents, functional recovery hematopoietic system, reducing pathological safeguarding lethal radiation. More importantly, showed selective organs without interferences tumor control cancer. Based on conveniently available tetrahedron-based nanocarrier, this work presents high-efficiency prolonged enhanced multi-organs. Such pioneers strategy translation potential radioactivity protection.

Language: Английский

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Targeting modulation of intestinal flora through oral route by an antimicrobial nucleic acid-loaded exosome-like nanovesicles to improve Parkinson’s disease

Science Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Ultrasound-Enhanced Mitochondrial Targeting for Synergistic Mitoxantrone-Based Nanotherapy in Triple-Negative Breast Cancer

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

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Spatiotemporally Programming Microenvironment to Recapitulate Endochondral Ossification via Greenhouse‐Inspired Bionic Niche

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract Various biomaterials have been developed to address challenging critical‐sized bone defects. However, most of them focus on intramembranous ossification (IMO) rather than endochondral (ECO), often resulting in suboptimal therapeutic outcomes. Drawing inspiration from the functionality greenhouse ecosystem, herein a bionic niche is innovatively crafted recapitulate ECO process. This consists three hierarchical components: an embedded microchannel network that facilitates cell infiltration and matter exchange, polydopamine surface modification layer with immunomodulatory functions, ECO‐targeted delivery system based mesoporous silica nanoparticles. Through spatiotemporally programming microenvironment, effectively recapitulates key stages ECO. Notably, even rat calvaria, region well‐known for IMO, capable initiating ECO, evident by cartilage template formation, leading efficient regeneration. Taken together, this study introduces prospective concepts designing next‐generation ECO‐driven tissue engineering.

Language: Английский

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Nanotherapeutic platform-mediated cholesterol metabolism regulation for boosting antitumor chemo-immunotherapy

Science China Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Language: Английский

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Photothermally-enhanced ferroptotic-chemo therapy enabled by ZIF-derived multizyme

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 398 - 407

Published: Dec. 14, 2024

Language: Английский

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Suppression of pathological neovascularization by anti-Flt1 peptide functionalized DNA tetrahedron

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153249 - 153249

Published: June 19, 2024

Language: Английский

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Liposome-like Nanoplatform Regulates Autophagy to Enhance Antitumor Chemo-Immunotherapy

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(22), P. 25447 - 25458

Published: Nov. 8, 2024

Studies on immunogenic cell death of tumor cells have confirmed that some chemotherapy drugs can induce antitumor immune response. This response is caused by the antigens released dead cells. However, these and damage-associated molecular patterns (DAMPs) be degraded autophagy pathway, which highly upregulated in shown inhibition increase accumulation autophagosomes, reduce degradation major histocompatibility complex (MHC) class I molecules, maintain or even enhance responses. In order to chemotherapy-induced through regulation autophagy, this project intends create a nanoplatform for codelivery chemotherapeutics inhibitors. Phospholipid-modified inhibitor DSPE-BiQ drug DSPE-OXA-PEG were synthesized, respectively, generated system OXA/BiQ-Lip could achieve efficient delivery release EPR effect stimulation from intracellular pH gradient/reduced glutathione concentration changing. The strategy inhibitors not only overcome oxaliplatin resistance but also promote intact autophagosomes containing multiple DAMPs, antigen presentation infiltration, improve triggered chemotherapy.

Language: Английский

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GSH-Responsive Bithiophene Aza-BODIPY@HMON Nanoplatform for Achieving Triple-Synergistic Photoimmunotherapy

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 242, P. 114109 - 114109

Published: July 18, 2024

Language: Английский

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Injectable hydrogel assisted formation of hydroxyl radical generating bioreactor enables photothermally enhanced chemodynamic and immunotherapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157141 - 157141

Published: Oct. 28, 2024

Language: Английский

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