Surface and Coatings Technology, Год журнала: 2024, Номер unknown, С. 131681 - 131681
Опубликована: Дек. 1, 2024
Язык: Английский
Advanced Functional Materials, Год журнала: 2024, Номер 34(48)
Опубликована: Июнь 26, 2024
Abstract The growing concerns regarding cancer recurrence, unpredictable bone deficiencies, and postoperative bacterial infections subsequent to the surgical removal of tumors have highlighted need for multifaceted scaffolds that afford tumor therapy, effective vascularized reconstruction. However, challenging trilemma has emerged in realm balance between achieving appropriate mechanical strength, ensuring biocompatibility, optimizing a degradation rate aligns with bone‐regenerative rate. Considering these challenges, innovative theragenerative platform is developed by utilizing 3D printing‐based nanospikes first time. This comprises tissue‐specific nanospiked hydroxyapatite decorated magnesium (nMg) adhesive DNA (aDNA). incorporation nMg within polylactic acid (PLA) matrix confers photothermal capabilities helps modulate properties improve biocompatibility platform. Simultaneously, immobilized aDNA contributed enhancement healing. These 3D‐printed tissue‐adhesive platforms exhibit superior offer controlled degradability. Moreover, they enable eradication bacteria osteosarcoma through hyperthermia promote angiogenesis osteogenesis, both vitro vivo. groundbreaking approach poised pave way fabrication design novel implantable biomaterials integrate therapeutic regenerative functions.
Язык: Английский
Процитировано
28
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 9, 2025
Despite advancements in biomimetic mineralization techniques, the repair of large-scale bone defects remains a significant challenge. Inspired by formation process, multidimensional cascade strategy is developed replicating biomineralization cascade, emulating hierarchical structure bone, and biomimicking its biological functions for efficient regeneration. This involves photocrosslinking sodium methacrylate carboxymethyl cellulose-stabilized amorphous magnesium-calcium phosphate with methacrylate-modified type I collagen to create self-mineralizing hydrogel. The hydrogel then integrated either naturally derived or synthetic oriented bulk scaffolds. resulting composite, named Osteomimix, provides excellent mechanical support can be customized irregular using CAD/CAM technology. Through vitro vivo studies, this work finds that Osteomimix exhibits spontaneous situ cell-free environment, while modulating immune responses promoting vascularized cell-dependent manner. Built on bone-specific insights, achieves biomimicry across temporal, spatial, functional dimensions, facilitating seamless integration artificial constructs natural tissue dynamics.
Язык: Английский
Процитировано
1
APL Photonics, Год журнала: 2024, Номер 9(9)
Опубликована: Сен. 1, 2024
This tutorial reviews the rapidly growing field of optical photothermal infrared (O-PTIR) spectroscopy and chemical imaging. O-PTIR is an super-resolution measurement technique where a shorter wavelength visible probe used to measure map (IR) absorption with spatial resolution up 30× better than conventional techniques such as Fourier transform direct IR laser imaging systems. article key limitations instruments, technology breakthroughs, their origins that have overcome prior limitations. also discusses recent developments in expanding multi-modal approaches enable complementary Raman fluorescence microscopy imaging, including wide-field fluorescence-based detection absorption. Various practical subjects are covered, sample preparation techniques, optimal configurations, use tags/labels for data analysis, visualization. Key applications reviewed many areas, biological biomedical sciences, environmental microplastics research, (bio)pharmaceuticals, materials science, cultural heritage, forensics, photonics, failure analysis.
Язык: Английский
Процитировано
8
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 156627 - 156627
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
8
Materials Letters, Год журнала: 2024, Номер 362, С. 136214 - 136214
Опубликована: Фев. 24, 2024
Язык: Английский
Процитировано
6
Small, Год журнала: 2024, Номер unknown
Опубликована: Сен. 30, 2024
Abstract Abnormal osteogenic and remodeling microenvironment due to osteoblast apoptosis are the primary causes of delayed fracture healing in osteoporotic patients. Magnesium (Mg) alloys exhibit biodegradability appropriate elastic moduli for bone defects osteoporosis, but effect on local disorder is still insufficient. Inspired by “honeycomb,” layered double hydroxide (LDH) with regular traps graphene oxide quantum dots (GOQDs) inlayed constructed pulsed electrodeposition generate GOQD/LDH composite nanocoatings surfaces Mg alloy substrates. The honeycomb bionic multi‐layer stereoscopic structure shows good regulation degradation support time required defect. Within its lattice, conducive osteogenesis provided both rescue GOQD LDH. rescued activation mitophagy clear dysfunctional mitochondria, where upregulation BNIP3 phosphorylation played a key role. rat model femoral confirmed improvement regeneration osseointegration coating. In summary, controllable excellent pro‐osteogenic performance demonstrated promising design strategy implants therapy defects.
Язык: Английский
Процитировано
5
Burns & Trauma, Год журнала: 2025, Номер 13
Опубликована: Янв. 1, 2025
Abstract Background Magnesium ions play crucial roles in maintaining cellular functions. Research has shown that Mg2+ can promote angiogenesis, indicating its potential for treating cardiovascular ischemic diseases. However, conventional intravenous or oral administration of presents several challenges, including the risk systemic side effects, diminished bioavailability, and a lack targeted delivery mechanisms. In this study, we designed an Mg2+-releasing adhesive tissue patch (MgAP) enables dural release ions. Methods A novel MgAP was developed on basis ionic crosslinking. Fourier transform infrared spectroscopy confirmed chemical structure, whereas rheological analysis demonstrated stable mechanical properties adaptability to dynamic loads. Sustained quantified over 7 days by inductively coupled plasma–mass spectrometry. rat acute myocardial infarction model, performed echocardiography strain assess cardiac function histological staining evaluate adverse remodeling. We also verified proangiogenic effect through vitro tube formation vivo immunofluorescence assays. Furthermore, transcriptomics Western blotting were explore underlying mechanism. Additional assessments carried out model lower limb ischemia. Results Compared with magnesium chloride, application effectively improved reduced remodeling model. The left ventricular ejection fraction increased 20.3 ± 6.6%, radial 27.4 4.1%. fibrosis area cell apoptosis rate decreased 10.9 1.2% 32.1 5.5%, respectively. RNA sequencing highlighted upregulation genes related electrophysiological properties, structural functional intercellular connections, revascularization. gap junction protein expression restored local blood supply could contribute repair process posttreatment. observed ischemia Conclusions above results revealed convincing vascular regeneration ion therapy-based hydrogel, which enabled tissue, aiding repair. This study strategy highlights use across various conditions.
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Фев. 20, 2025
The advancement of controllable mineral adhesion materials has significantly impacted various sectors, including industrial production, energy utilization, biomedicine, construction engineering, food safety, and environmental management. Natural biological exhibit distinctive properties that inspire the design artificial systems for controlling adhesion. In recent decades, researchers have sought to create bioinspired effectively regulate adhesion, accelerating development functional across emerging fields. Herein, we review advances in mineralized antiscaling materials. First, a systematic overview nature is provided. Then, mechanism latest characterization between minerals material surfaces are introduced. Later, designed presented, ranging from molecular level micro/nanostructures, Additionally, applications these fields discussed, such as management, highlighting their roles promoting or inhibiting aspects. Finally, summarize ongoing challenges offer perspective on future this charming field.
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2025, Номер 49, С. 608 - 626
Опубликована: Март 29, 2025
Язык: Английский
Процитировано
0
Rare Metals, Год журнала: 2025, Номер unknown
Опубликована: Май 9, 2025
Язык: Английский
Процитировано
0