Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Язык: Английский

---

A Dual‐Targeting Biomimetic Nanoplatform Integrates SDT/CDT/Gas Therapy to Boost Synergistic Ferroptosis for Orthotopic Hepatocellular Carcinoma Therapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements, not only decomposes H 2 O generate oxygen alleviate tumor hypoxia but also depletes glutathione inactivate peroxides 4, which amplify sonodynamic under ultrasound (US) irradiation. Meanwhile, catalyzes Fenton reaction produce hydroxyl radicals chemodynamic therapy. Elevated intracellular reactive species trigger cascade release CO, leading lethal lipid peroxidation enhancing ferroptosis‐mediated This demonstrates robust anti‐tumor efficacy US irradiation favorable biosafety in both subcutaneous orthotopic HCC models, representing a promising approach Additionally, findings offer new insights into microenvironment modulation optimize US‐triggered cancer

Язык: Английский

---

Applications and Enhancement Strategies of ROS-based Non-invasive Therapies in Cancer Treatment

Redox Biology, Год журнала: 2025, Номер unknown, С. 103515 - 103515

Опубликована: Янв. 1, 2025

Язык: Английский

---

Anion exchange regulated charge separation engineering in bismuth nanoflowers for sonocatalytic radio-immunotherapy

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 687, С. 801 - 816

Опубликована: Фев. 17, 2025

Язык: Английский

---

Ruthenium Single‐Atom Nanozyme Driven Sonosensitizer with Oxygen Vacancies Enhances Electron–Hole Separation Efficacy and Remodels Tumor Microenvironment for Sonodynamic‐Amplified Ferroptosis

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Abstract Sonodynamic therapy (SDT) has emerged as a promising noninvasive approach for tumor therapy. However, the effectiveness of traditional inorganic semiconductor sonosensitizers is hindered by rapid electron (e − ) and hole (h + recombination under ultrasonic (US) stimulation, well hypoxic reductive conditions microenvironment (TME), which limit generation reactive oxygen species (ROS). Herein, ruthenium (Ru) single‐atom nanozyme‐driven superimposition‐enhanced titanium dioxide‐based sonosensitizer (Ru/TiO 2‐x SAE) presented that features sufficient vacancies high e /h separation efficiency. Through synchrotron radiation‐based X‐ray absorption spectroscopy extended fine structure analysis it confirmed in TiO nanoparticles promote immobilization single‐atomic Ru, forming Ru‐O₄ active sites. Density functional theory calculations demonstrate alter electronic nanosensitizer, enhanced separation, increasing adsorption, accelerating reaction kinetics US ultimately improving ROS production. Moreover, Ru/TiO SAE boosts sonodynamic efficacy mitigating TME. This attributed to its catalase‐ glutathione peroxidase 4‐like activities, facilitate trigger lipid peroxidation‐mediated ferroptosis. These findings highlight innovative role Ru optimizing SDT‐induced ferroptosis, demonstrating potential advancing cancer

Язык: Английский

---

Ultrasound-responsive nanoweapons: covalent organic frameworks for cancer sonodynamic therapy

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Sonodynamic therapy (SDT), characterized by its non-invasiveness, low toxicity, and deep tissue penetration, has emerged as a promising therapeutic modality for anticancer treatments. Recently, covalent organic frameworks (COFs) have garnered significant attention in the SDT realm powerful versatile toolbox. Notably, COF-based achieved many encouraging outcomes owing to remarkable potential of COFs, volume related research experienced continuous growth. Therefore, we strive provide timely comprehensive review that thoroughly summarizes advancements SDT. This begins with concise yet summary ultrasonic cavitation sonodynamic effects, elucidating fundamental principles mechanisms Subsequently, it delves into chemistry examining intricate structure designs, various types linkages, diverse synthetic methods. The primary focus this is summarize sonosensitizers, including construction strategies product properties. More importantly, role COFs combined therapies described detail, aiming highlight advantages COF-enhanced synergistic Finally, points out current challenges future opportunities rapidly evolving field. Overall, deliberations overviews sonosensitizers are expected facilitate advancements, leading early-stage clinical benefits patients.

Язык: Английский

---

Lymphocyte‐Mimicking Sonosensitizers Boost Cancer Immunotherapy via Sequential Ultrasound Activation

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 24, 2025

Abstract Effective initiation of the cancer‐immunity cycle is core challenge tumor immunotherapy, which relies on coordinated antigen release and immunostimulation. To address this issue, work introduced a novel lymphocyte‐mimicking sonosensitizer using Mn‐doped hollow Prussian blue nanoparticle (Mn‐HP) for cancer sonodynamic therapy (SDT) to efficiently evoke anticancer immunity. The prepared Mn‐HP have unique architecture amplify ultrasonic cavitation effects, boosting spatially controlled reactive oxygen species (ROS) production. Through effective combination lymphocytes, Lymphocyte‐mimicking (Lymphocytes‐Mn‐HP, LM) with “Homing effect” constructed. sequenced dual‐ultrasound strategy employs high‐power ultrasound (2.0 W cm −2 ) stimulation (excessive ROS) low‐power (0.5 (moderate lymph node active immune cells, enabling precise spatial‐temporal ROS generation while preserving function. Both in vitro vivo studies demonstrated significant suppression through initiating cycle, offering transformative paradigm SDT‐immunotherapy integration.

Язык: Английский

---

Regulating Manganese-Site Electronic Structure via Reconstituting Nitrogen Coordination for Efficient Non-Oxygen-Dependent Sonocatalytic Therapy against Orthotopic Breast Cancer

ACS Nano, Год журнала: 2024, Номер unknown

Опубликована: Сен. 26, 2024

Sonocatalytic therapy (SCT) has emerged as a promising noninvasive modality for tumor treatment but is hindered by the insufficient generation of ultrasound-induced reactive oxygen species (ROS) and hypoxic microenvironments. Herein, we fabricated carbon nanoframe-confined N-coordinated manganese single-atom sonocatalyst with five-coordinated structure (MnN

Язык: Английский

---

Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Piezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the complexities of microenvironment. In this study, sulfur vacancy‐engineered cobalt (Co) single‐atom doped molybdenum disulfide (SA‐Co@MoS 2 ) nanoflowers are strategically designed, which exhibit enhanced effects. Specifically, introduction Co single atom not only induces lattice distortion out‐of‐plane polarization but also leads to formation numerous vacancies. These changes collectively narrow intrinsic bandgap material, facilitating effective separation migration charge carriers, enabling efficient production reactive oxygen species under ultrasound stimulation. Additionally, SA‐Co@MoS demonstrate improved enzymatic activity glutathione depletion capabilities attributed mixed valence states Co, intensifying oxidative stress cells, leading cell cycle arrest apoptosis, while inactivation peroxidase 4 ferroptosis. Both vitro vivo results indicate that can significantly eliminate cells. This study offers valuable insights into exploration doping‐enhanced sonosensitizers for cancer treatment, potentially paving way advancements field synergistic enzyodynamic therapy.

Язык: Английский

---

Charge separation engineering modulates self-oxygenating nano-heterojunctions to induce ferroptosis for sonodynamic-immunotherapy of tumors

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160713 - 160713

Опубликована: Фев. 1, 2025

Язык: Английский

---