Journal of Colloid and Interface Science, Год журнала: 2024, Номер 683, С. 132 - 146
Опубликована: Дек. 10, 2024
Язык: Английский
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Bone defects resulting from trauma, tumors, or other injuries significantly impact human health and quality of life. However, current treatments for bone are constrained by donor shortages immune rejection. tissue engineering has partially alleviated the limitations traditional repair methods. The development smart biomaterials that can respond to external stimuli modulate biofunctions become a prominent area research. Ultrasound technology is regarded as an optimal "remote controller" "trigger" biomaterials. This review reports comprehensive systematic overview ultrasound-responsive It presents fundamental theories repair, definition ultrasound, its applications. Furthermore, summarizes ultrasound effect mechanisms their roles in including detailed studies on anti-inflammation, immunomodulation, cell therapy. Finally, advantages future prospects this field discussed.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Март 8, 2025
Piezocatalyst-enabled sonopiezoelectric therapy offers noninvasive treatment with high spatiotemporal selectivity, yet existing piezocatalysts are limited by suboptimal efficacy, cancer cell resistance to oxidative stress, and biosafety concerns. Here, hafnia (HfO2), one of the only few FDA-approved inorganic nanomaterials for clinical trials, is identified as a promising piezocatalyst translational potential enzymatic PANoptosis-boosted nanocatalytic therapy. Specifically, engineered transition metal-substituted HfO2 nanocatalysts synthesized optimize piezoelectric enzyme-mimicking activities. Among these, Mn-substituted 20% Mn ratio (HMO) demonstrates superior performance in sono-triggered reactive oxygen species generation, attributed its reduced bandgap increased vacancies. HMO also exhibits multiple activities, including peroxidase (POD), catalase (CAT), glutathione (GPx), amplifying stress through tumor-specific catalytic reactions. These dual effects enable activation PANoptosis elicit robust antitumor immune response. Biological evaluations show significant tumor suppression responses HMO-mediated Unlike utilizing radiosensitization ability clinic, this work unveils distinctive effect multienzymatic activities HfO2-based biomedical applications, holding overcome challenges radiation damage associated radiotherapy.
Язык: Английский
Процитировано
0
Nano Letters, Год журнала: 2025, Номер unknown
Опубликована: Апрель 2, 2025
The design of nanozymes with controlled properties and well-defined mechanisms holds significant promise for advancing next-generation functional biomaterials tumor theranostics. Here, we develop a metal-organic framework (MOF)-derived bimetallic sulfide nanozyme, FCS, ferrotherapy via combined photothermal catalytic therapies. FCS is synthesized by vulcanizing the zeolitic imidazolate framework-67 (ZIF-67) into cobalt (Co3S4, CS), followed ferrous cation exchange, resulting in enhanced near-infrared II conversion superior Fenton-like activity. Theoretical calculations attribute these enhancements to Fe doping, which narrows band gap, promotes electron transfer H2O2, lowers energy barrier active oxygen species generation. effectively induces ferroptosis through lipid peroxidation, while supporting T2-weighted magnetic resonance imaging. This study presents robust strategy MOF transformation multifunctional theranostic agents, highlighting role metal ion doping optimizing nanozyme performance.
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 10, 2025
Abstract Sonocatalytic therapy is gaining interest for its non‐invasive nature, precise control, and excellent tissue penetration, making it a promising approach treating malignant tumors. While defect engineering enhances electron hole separation to boost reactive oxygen species (ROS) generation, challenges in constructing effective traps compared severely limit ROS production. In this study, 2D ZnIn 2 S 4 ‐V nanosheets enriched are rationally designed with vacancies the efficient capture of electrons holes, which has achieved substantial sonocatalytic performance suppressing tumor growth. Compared pristine nanosheets, possess periodic electrostatic potential inherent their structure, effectively disrupt field, promote simultaneous migration charge carriers, inhibit recombination, thereby boosting production inducing cell pyroptosis via ROS‐NLRP3‐caspase‐1‐GSDMD pathway under ultrasound (US) irradiation. Furthermore, both exhibited remarkable biocompatibility. vitro vivo antineoplastic experiments demonstrate that promotes elimination, underscoring critical importance defect‐engineered optimization therapy.
Язык: Английский
Процитировано
0
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.
Язык: Английский
Процитировано
0
Acta Biomaterialia, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Hepatocellular carcinoma (HCC) is the most common primary malignant disease of liver. Although immunotherapy offers new opportunities for treating advanced HCC, its therapeutic effect still limited by immunosuppressive tumor microenvironment (TME). Herein, a nanosensitizer RGD@Ce6@MSA-2@Liposome (RCM-Lip) synthesized to specifically initiate HCC immune through sonodynamic therapy (SDT)-triggered immunogenic cell death (ICD) and MSA-2-activated cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway. RCM-Lip consists sonosensitizer (Chlorin e6, Ce6) with STING agonist (MSA-2) targeting peptide RGD inserted on outer liposome surface. Under ultrasound irradiation, generates reactive oxygen species that induce cytotoxicity apoptosis cells. Meanwhile, antigens released are taken up dendritic cells (DCs), while activated in DCs MSA-2. Moreover, DC maturation stimulated, further enhancing systematic anti-tumor responses. Sono-immunotherapy mediated promotes infiltration CD8+T cells, increasing inflammatory cytokine secretion. Consequently, immunologically "cold" TME successfully turned into "hot" one, leading significant suppression good bio-safety. These results suggest promising method precise synergistic cancer sono-immunotherapy. STATEMENT OF SIGNIFICANCE: Our study addressed dilemma hepatocellular as an immunological application (SDT) agonist. The cGAS-STING signaling pathway plays pivotal role innate immunity against cancer, but clinical agonists were hampered responses due off-target activation. innovative solution introduces RGD-targeted encapsulate agonist, strengthening effects reducing systemic toxicity. targeted sono-immunotherapy promoted producing intense tumor-killing mice model As result, one.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Май 13, 2025
Malignant tumour represents a significant global public health concern. The advent of immunotherapy has brought about revolutionary shift in the landscape treatment, offering ray hope to patients across globe. Immunotherapy strategies have demonstrated considerable promise clinical trials. However, immunosuppressive environment within microenvironment constituted obstacle advancement immunotherapies. It is therefore imperative develop more efficacious and personalised approaches. utilisation non-invasive ultrasound-assisted promising strategy. Ultrasound capacity induce an immune response stimulate other drugs achieve specific response, thereby reducing toxic side effects treatment enhancing outcome immunotherapy. This paper presents systematic introduction various mechanisms related ultrasound reviews recent advancements immunotherapy, including ultrasonic ablation, combined application with contrast agents, sonodynamic therapy.
Язык: Английский
Процитировано
0
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 6533 - 6549
Опубликована: Май 1, 2025
Control systems play an important role in the diagnosis and treatment of medicine. In contrast to light magnetic fields, ultrasound has received much attention due its non-invasive, cost-effective, convenient, high spatiotemporal precision deep-penetration characteristics. Some studies have developed special nanomaterials for therapy by controlling production reactive oxygen species through irradiation. However, complex functionalities toxicity issues associated with these limit development control systems. To overcome challenges, based on synthetic biology been developed, especially sonogenetics gas vesicles. The tunable thermal mechanical effects act as main triggering source, enabling engineered cells perform sono-thermal or sono-mechanical genetic modifications targeted tissue. Based in-depth understanding relationship between design, composition, applications cellular technologies, this review, we focus recent activation strategies vesicles, including promoter switch, transient receptor potential channel, addition, advanced cancer therapy, neural activity, visual recovery functional imaging are presented. Finally, discuss current challenges faced provide outlook future developments evolving field.
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Май 30, 2025
Abstract Sonodynamic therapy (SDT) has emerged as a promising strategy for neuroblastoma treatment, leveraging ultrasound to induce the production of reactive oxygen species (ROS) at tumor sites, thereby enhancing efficacy immunotherapy. However, major challenge in SDT is efficiency ROS generation, particularly context hypoxia within microenvironment. Herein, inspired by natural peroxidase, an imide‐linked metal‐phthalocyanine‐based conjugated organic polymer (COP) (COP TPcFe ) been designed with well‐defined π‐conjugated nanostructure and peroxidase‐mimetic atomic Fe‐N sites sonochemodynamic immunotherapy against neuroblastoma. This work demonstrates that COP can efficiently produce potent (•OH •O 2 − utilizing localized H O effects ultrasound, achieving efficient synergistic tumoricidal activity. Notably, highly structure endows excellent electron transport capabilities, enabling rapid catalysis , thus alleviating hypoxic conditions tumors. Moreover, encapsulating cell membranes, this study achieveshomologous targeting cells tissues, leading accumulation cells, mitochondrial disruption, apoptosis. Additionally, proposed effectively activates killer reverses immunosuppressive microenvironment, significantly therapeutic treatment.
Язык: Английский
Процитировано
0
Angewandte Chemie, Год журнала: 2024, Номер unknown
Опубликована: Сен. 21, 2024
Abstract Pyroptosis, an inflammatory modality of programmed cell death associated with the immune response, can be initiated by bioactive ions and reactive oxygen species (ROS). However, ion‐induced pyroptosis lacks specificity, further exploration other that induce in cancer cells is needed. Sonocatalytic therapy (SCT) holds promise due to its exceptional penetration depth; however, rapid recombination electron‐hole (e − ‐h + ) pairs complex tumor microenvironment (TME) impede broader application. Herein, we discovered antimony (Sb)‐based nanomaterials induced cells. Therefore, Schottky heterojunctions containing Sb component (Sb 2 Se 3 @Pt) were effectively designed constructed via situ growth platinum (Pt) nanoparticles (NPs) on semiconductor narrow band gaps, which utilized as US‐heightened initiators highly effective boost SCT‐immunotherapy. Under US irradiation, excited electrons transferred from nanorods (NRs) co‐catalyst Pt junctions, bending prevented electron backflow achieved efficient ROS generation. Moreover, pores oxidized depleted overexpressed GSH TME, potentially amplifying The biological effects @Pt nanoheterojunction itself combined sonocatalytic amplification oxidative stress significantly Caspase‐1/GSDMD‐dependent SCT treatment not only restrained proliferation but also potent memory responses suppressed recurrence. Furthermore, integration this innovative strategy checkpoint blockade (ICB) elicited a systemic augmenting therapeutic impeding abscopal tumors. Overall, study provides opportunities explore pyroptosis‐mediated
Язык: Английский
Процитировано
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