Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 132 - 146
Published: Dec. 10, 2024
Language: Английский
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Bone defects resulting from trauma, tumors, or other injuries significantly impact human health and quality of life. However, current treatments for bone are constrained by donor shortages immune rejection. tissue engineering has partially alleviated the limitations traditional repair methods. The development smart biomaterials that can respond to external stimuli modulate biofunctions become a prominent area research. Ultrasound technology is regarded as an optimal "remote controller" "trigger" biomaterials. This review reports comprehensive systematic overview ultrasound-responsive It presents fundamental theories repair, definition ultrasound, its applications. Furthermore, summarizes ultrasound effect mechanisms their roles in including detailed studies on anti-inflammation, immunomodulation, cell therapy. Finally, advantages future prospects this field discussed.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 25, 2025
Abstract Sonodynamic therapy (SDT) has emerged as a promising noninvasive approach for tumor therapy. However, the effectiveness of traditional inorganic semiconductor sonosensitizers is hindered by rapid electron (e − ) and hole (h + recombination under ultrasonic (US) stimulation, well hypoxic reductive conditions microenvironment (TME), which limit generation reactive oxygen species (ROS). Herein, ruthenium (Ru) single‐atom nanozyme‐driven superimposition‐enhanced titanium dioxide‐based sonosensitizer (Ru/TiO 2‐x SAE) presented that features sufficient vacancies high e /h separation efficiency. Through synchrotron radiation‐based X‐ray absorption spectroscopy extended fine structure analysis it confirmed in TiO nanoparticles promote immobilization single‐atomic Ru, forming Ru‐O₄ active sites. Density functional theory calculations demonstrate alter electronic nanosensitizer, enhanced separation, increasing adsorption, accelerating reaction kinetics US ultimately improving ROS production. Moreover, Ru/TiO SAE boosts sonodynamic efficacy mitigating TME. This attributed to its catalase‐ glutathione peroxidase 4‐like activities, facilitate trigger lipid peroxidation‐mediated ferroptosis. These findings highlight innovative role Ru optimizing SDT‐induced ferroptosis, demonstrating potential advancing cancer
Language: Английский
Citations
0
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Hepatocellular carcinoma (HCC) is the most common primary malignant disease of liver. Although immunotherapy offers new opportunities for treating advanced HCC, its therapeutic effect still limited by immunosuppressive tumor microenvironment (TME). Herein, a nanosensitizer RGD@Ce6@MSA-2@Liposome (RCM-Lip) synthesized to specifically initiate HCC immune through sonodynamic therapy (SDT)-triggered immunogenic cell death (ICD) and MSA-2-activated cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway. RCM-Lip consists sonosensitizer (Chlorin e6, Ce6) with STING agonist (MSA-2) targeting peptide RGD inserted on outer liposome surface. Under ultrasound irradiation, generates reactive oxygen species that induce cytotoxicity apoptosis cells. Meanwhile, antigens released are taken up dendritic cells (DCs), while activated in DCs MSA-2. Moreover, DC maturation stimulated, further enhancing systematic anti-tumor responses. Sono-immunotherapy mediated promotes infiltration CD8+ T cells, increasing inflammatory cytokine secretion. Consequently, immunologically "cold" TME successfully turned into "hot" one, leading significant suppression good bio-safety. These results suggest promising method precise synergistic cancer sono-immunotherapy. STATEMENT OF SIGNIFICANCE: Our study addressed dilemma hepatocellular as an immunological application (SDT) agonist. The cGAS-STING signaling pathway plays pivotal role innate immunity against cancer, but clinical agonists were hampered responses due off-target activation. innovative solution introduces RGD-targeted encapsulate agonist, strengthening effects reducing systemic toxicity. targeted sono-immunotherapy promoted producing intense tumor-killing mice model As result, one.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 26, 2024
Sonocatalytic therapy (SCT) has emerged as a promising noninvasive modality for tumor treatment but is hindered by the insufficient generation of ultrasound-induced reactive oxygen species (ROS) and hypoxic microenvironments. Herein, we fabricated carbon nanoframe-confined N-coordinated manganese single-atom sonocatalyst with five-coordinated structure (MnN
Language: Английский
Citations
3
Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 21, 2024
Abstract Pyroptosis, an inflammatory modality of programmed cell death associated with the immune response, can be initiated by bioactive ions and reactive oxygen species (ROS). However, ion‐induced pyroptosis lacks specificity, further exploration other that induce in cancer cells is needed. Sonocatalytic therapy (SCT) holds promise due to its exceptional penetration depth; however, rapid recombination electron‐hole (e − ‐h + ) pairs complex tumor microenvironment (TME) impede broader application. Herein, we discovered antimony (Sb)‐based nanomaterials induced cells. Therefore, Schottky heterojunctions containing Sb component (Sb 2 Se 3 @Pt) were effectively designed constructed via situ growth platinum (Pt) nanoparticles (NPs) on semiconductor narrow band gaps, which utilized as US‐heightened initiators highly effective boost SCT‐immunotherapy. Under US irradiation, excited electrons transferred from nanorods (NRs) co‐catalyst Pt junctions, bending prevented electron backflow achieved efficient ROS generation. Moreover, pores oxidized depleted overexpressed GSH TME, potentially amplifying The biological effects @Pt nanoheterojunction itself combined sonocatalytic amplification oxidative stress significantly Caspase‐1/GSDMD‐dependent SCT treatment not only restrained proliferation but also potent memory responses suppressed recurrence. Furthermore, integration this innovative strategy checkpoint blockade (ICB) elicited a systemic augmenting therapeutic impeding abscopal tumors. Overall, study provides opportunities explore pyroptosis‐mediated
Language: Английский
Citations
1
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 681, P. 319 - 330
Published: Nov. 23, 2024
Language: Английский
Citations
1
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 15, 2024
Cancer immunotherapy holds significant promise for improving cancer treatment efficacy; however, the low response rate remains a considerable challenge. To overcome this limitation, advanced catalytic materials offer potential in augmenting by modulating immunosuppressive tumor microenvironment (TME) through precise biochemical reactions. Achieving optimal targeting precision and therapeutic efficacy necessitates thorough understanding of properties underlying mechanisms tumor-targeted materials. This review provides comprehensive systematic overview recent advancements their critical role enhancing immunotherapy. It highlights types reactions, construction strategies materials, fundamental targeting, including passive, bioactive, stimuli-responsive, biomimetic approaches. Furthermore, outlines various tumor-specific strategies, encompassing tissue, cell, exogenous TME-responsive, cellular TME strategies. Finally, discussion addresses challenges future perspectives transitioning into clinical applications, offering insights that pave way next-generation therapies provide substantial benefits to patients settings.
Language: Английский
Citations
1
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 132 - 146
Published: Dec. 10, 2024
Language: Английский
Citations
0