Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(12), С. 5161 - 5180
Опубликована: Авг. 23, 2024
Microneedles
(MNs)
serve
as
a
revolutionary
paradigm
in
transdermal
drug
delivery,
heralding
viable
resolution
to
the
formidable
barriers
presented
by
cutaneous
interface.
This
review
examines
MNs
an
advanced
approach
enhancing
dermatological
pathology
management.
It
explores
complex
dermis
structure
and
highlights
limitations
of
traditional
methods,
emphasizing
MNs'
advantage
bypassing
stratum
corneum
deliver
drugs
directly
subdermal
matrix.
The
discourse
outlines
diverse
typologies
MNs,
including
solid,
coated,
hollow,
hydrogel,
dissolvable
versions.
Each
type
is
characterized
its
unique
applications
benefits.
treatise
details
deployment
alleviation
cancers,
administration
inflammatory
dermatoses
such
psoriasis
atopic
dermatitis,
their
utility
wound
Additionally,
paper
contemplates
prospects
within
realm
aesthetic
dermatology
burgeoning
market
traction
cosmetic
MN
formulations.
summarizes
scientific
commercial
challenges
clinical
adoption
therapeutics,
dosage
calibration,
pharmacodynamics,
biocompatibility,
patient
compliance,
sterilization,
mass
production,
regulatory
oversight.
emphasizes
need
for
ongoing
research,
innovation,
harmonization
overcome
these
obstacles
fully
realize
potential
treating
skin
diseases
improving
welfare.
presents
comprehensive
overview
recent
accomplishments,
remaining
challenges,
future
microneedle-facilitated
therapy
afflictions.
Язык: Английский
Research progress of sorafenib drug delivery system in the treatment of hepatocellular carcinoma: An update
Qiang-qiang Fan,
Huan Tian,
Jiangxue Cheng
и другие.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117118 - 117118
Опубликована: Июль 14, 2024
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
prevalent
malignant
tumors
in
contemporary
era,
representing
a
significant
global
health
concern.
Early
HCC
patients
have
mild
symptoms
or
are
asymptomatic,
which
promotes
onset
and
progression
disease.
Moreover,
advanced
insensitive
to
chemotherapy,
making
traditional
clinical
treatment
unable
block
cancer
development.
Sorafenib
(SFB)
first-line
targeted
drug
for
with
anti-angiogenesis
anti-tumor
cell
proliferation
effects.
However,
efficacy
SFB
constrained
by
its
off-target
distribution,
rapid
metabolism,
multi-drug
resistance.
In
recent
years,
nanoparticles
based
on
variety
materials
been
demonstrated
enhance
targeting
therapeutic
against
HCC.
Concurrently,
advent
joint
delivery
systems
has
furnished
crucial
empirical
evidence
reversing
This
review
will
summarize
application
nanotechnology
field
over
past
five
years.
It
focus
research
progress
combined
multiple
modalities
treatment.
Язык: Английский
Advances in dissolving microneedles-based drug delivery system for treating dermatological diseases
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106785 - 106785
Опубликована: Март 1, 2025
Язык: Английский
Cryo-microneedle enabled transdermal delivery of two-dimensional Cu(Ⅱ)-TCPP nanomaterials for synergistic photodynamic-chemodynamic anti-tumor therapy
European Polymer Journal,
Год журнала:
2025,
Номер
unknown, С. 113888 - 113888
Опубликована: Март 1, 2025
Язык: Английский
Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration
Churong Xu,
Fei Wu,
Zhouyi Duan
и другие.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Май 3, 2025
Язык: Английский
Combinative dual-nanoparticle assembly improves oxygen-autarky PDT efficacy in hypoxic tumors
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 163836 - 163836
Опубликована: Май 1, 2025
Язык: Английский
Electrostatic Force-Enabled Microneedle Patches that Exploit Photoredox Catalysis for Transdermal Phototherapy
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
17(2), С. 3038 - 3051
Опубликована: Дек. 31, 2024
Microneedle
patches
for
topical
administration
of
photodynamic
therapy
(PDT)
sensitizers
are
attractive
owing
to
their
safety,
selectivity,
and
noninvasiveness.
However,
low-efficiency
photosensitizer
delivery
coupled
with
the
limitations
hypoxic
tumor
microenvironment
remains
challenging.
To
overcome
these
issues,
we
developed
an
effective
microneedle
patch
based
on
intermolecular
electrostatic
interactions
within
a
matrix
containing
zinc-containing
porphyrin
analogue,
ZnBP
(w).
This
design
improved
mechanical
strength
enhanced
loading
efficiency
in
aqueous
environments.
A
key
feature
system
is
efficient
electron
transfer
between
(w)
NADH
upon
photoirradiation.
Electrostatic
were
hypothesized
support
initial
binding
subsequent
photoinduced
transfer,
disrupting
NADH/NAD+
homeostasis
inducing
cell
death.
The
demonstrated
antiangiogenesis
effect
vascular
malformation
model
antitumor
melanoma
mouse
after
transdermal
administration.
study
highlights
benefits
designing
PDT
clinical
potential,
particularly
reducing
systemic
phototoxicity.
Язык: Английский
Active integrated fabrication method and evaluation of polymer with microneedles LED light source integration
Microsystem Technologies,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 6, 2024
Язык: Английский
Effect of photodynamic therapy on peripheral immune system for unresectable cholangiocarcinoma
Photodiagnosis and Photodynamic Therapy,
Год журнала:
2024,
Номер
49, С. 104279 - 104279
Опубликована: Авг. 20, 2024
Photodynamic
therapy
(PDT)
has
been
emerging
as
a
promising
treatment
for
unresectable
cholangiocarcinoma
(CCA).
A
number
of
experiments
have
demonstrated
that
PDT
could
enhance
antitumor
immunity
significantly.
However,
the
impact
on
peripheral
immune
system
CCA
remains
unclear.
Язык: Английский