Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(12), С. 5161 - 5180

Опубликована: Авг. 23, 2024

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.

Язык: Английский

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Research progress of sorafenib drug delivery system in the treatment of hepatocellular carcinoma: An update

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 117118 - 117118

Опубликована: Июль 14, 2024

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors in contemporary era, representing a significant global health concern. Early HCC patients have mild symptoms or are asymptomatic, which promotes onset and progression disease. Moreover, advanced insensitive to chemotherapy, making traditional clinical treatment unable block cancer development. Sorafenib (SFB) first-line targeted drug for with anti-angiogenesis anti-tumor cell proliferation effects. However, efficacy SFB constrained by its off-target distribution, rapid metabolism, multi-drug resistance. In recent years, nanoparticles based on variety materials been demonstrated enhance targeting therapeutic against HCC. Concurrently, advent joint delivery systems has furnished crucial empirical evidence reversing This review will summarize application nanotechnology field over past five years. It focus research progress combined multiple modalities treatment.

Язык: Английский

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Advances in dissolving microneedles-based drug delivery system for treating dermatological diseases

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106785 - 106785

Опубликована: Март 1, 2025

Язык: Английский

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Cryo-microneedle enabled transdermal delivery of two-dimensional Cu(Ⅱ)-TCPP nanomaterials for synergistic photodynamic-chemodynamic anti-tumor therapy

European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113888 - 113888

Опубликована: Март 1, 2025

Язык: Английский

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Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Май 3, 2025

Язык: Английский

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Combinative dual-nanoparticle assembly improves oxygen-autarky PDT efficacy in hypoxic tumors

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163836 - 163836

Опубликована: Май 1, 2025

Язык: Английский

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Electrostatic Force-Enabled Microneedle Patches that Exploit Photoredox Catalysis for Transdermal Phototherapy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 17(2), С. 3038 - 3051

Опубликована: Дек. 31, 2024

Microneedle patches for topical administration of photodynamic therapy (PDT) sensitizers are attractive owing to their safety, selectivity, and noninvasiveness. However, low-efficiency photosensitizer delivery coupled with the limitations hypoxic tumor microenvironment remains challenging. To overcome these issues, we developed an effective microneedle patch based on intermolecular electrostatic interactions within a matrix containing zinc-containing porphyrin analogue, ZnBP (w). This design improved mechanical strength enhanced loading efficiency in aqueous environments. A key feature system is efficient electron transfer between (w) NADH upon photoirradiation. Electrostatic were hypothesized support initial binding subsequent photoinduced transfer, disrupting NADH/NAD+ homeostasis inducing cell death. The demonstrated antiangiogenesis effect vascular malformation model antitumor melanoma mouse after transdermal administration. study highlights benefits designing PDT clinical potential, particularly reducing systemic phototoxicity.

Язык: Английский

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Active integrated fabrication method and evaluation of polymer with microneedles LED light source integration

Microsystem Technologies, Год журнала: 2024, Номер unknown

Опубликована: Авг. 6, 2024

Язык: Английский

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Effect of photodynamic therapy on peripheral immune system for unresectable cholangiocarcinoma

Photodiagnosis and Photodynamic Therapy, Год журнала: 2024, Номер 49, С. 104279 - 104279

Опубликована: Авг. 20, 2024

Photodynamic therapy (PDT) has been emerging as a promising treatment for unresectable cholangiocarcinoma (CCA). A number of experiments have demonstrated that PDT could enhance antitumor immunity significantly. However, the impact on peripheral immune system CCA remains unclear.

Язык: Английский

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