The Emerging Role of Nanoparticles Combined with Either Radiotherapy or Hyperthermia in Head and Neck Cancer: A Current Review
Cancers,
Год журнала:
2025,
Номер
17(5), С. 899 - 899
Опубликована: Март 6, 2025
Head
and
neck
cancer
(HNC)
includes
various
malignancies
represents
the
seventh
most
common
worldwide.
The
early
diagnosis
of
HNC
results
in
a
70-90%
five-year
survival
rate,
which
declines
with
locally
advanced
stages
disease.
Current
care
employs
multimodal
strategy
encompassing
surgery,
radiation
therapy
(RT),
chemotherapy,
immunotherapy,
while
treatment
options
vary
according
to
stage,
tumor
features,
patient
characteristics.
About
75%
patients
will
benefit
from
RT,
either
as
primary
or
adjuvant
following
surgical
resection.
Technological
improvements
such
intensity-modulated
RT
(IMRT)
image-guided
(IGRT),
have
enhanced
targeting
minimized
adjacent
healthy
tissue
irradiation
also
expanding
recurrent
metastatic
setting.
Innovative
therapeutic
strategies
for
integrate
gene
therapy,
molecular
targeted
photodynamic
photothermal
nanoparticles
(NPs),
objective
optimizing
control
reducing
damage
normal
tissues.
NPs
are
emerging
possible
radiosensitizers
treatment,
enhancing
efficacy
immunotherapy.
In
vivo
vitro
studies
on
tumors
containing
gold
(Au),
gadolinium
(Gd),
hafnium
oxide
(HfO2)
show
promising
destruction
rates,
indicating
their
potential
clinical
application.
Hyperthermia,
investigated
an
adjunct
potentially
improves
outcomes
when
combined
advancements
nanotechnology
renewing
interest
this
approach
HNC.
At
present,
NBTXR3
is
sole
NP
that
being
trials
enhancement
RT.
Язык: Английский
In Vivo Combined Photoacoustic Imaging and Photothermal Treatment of HPV‐Negative Head and Neck Carcinoma with NIR‐Responsive Non‐Persistent Plasmon Nano‐Architectures
Advanced Therapeutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 6, 2024
Abstract
The
combination
of
photoacoustic
imaging
(PAI)
and
photothermal
therapy
(PTT)
is
an
attractive
approach
in
cancer
management
due
to
the
non‐invasive
features
combined
with
real‐time
selective
tissue
damage
by
non‐ionizing
radiation.
This
especially
appealing
for
Head
Neck
Squamous
Cell
Carcinoma
(HNSCC)
management,
where
up
40%
patients
require
modifications
treatment
regimen.
On
other
hand,
most
agents
developed
PAI/PTT
suffer
from
persistence
or
re‐shaping
issues.
Here,
a
unique
non‐persistent
plasmon
nano‐architecture
(
t
NAs‐IRDye)
presented
that
simultaneously
acts
as
contrast
agent
PAI
transducer
PTT.
NAs‐IRDye
are
fully
characterized
evaluated
vitro
ex
vivo,
their
performance
theranostic
assessed
HPV‐negative
HNSCC
murine
models.
A
significant
modulation
tumor
growth
obtained
vivo
upon
intratumoral
injection
subsequent
NIR
irradiation
compared
solely
irradiated
control.
outcomes
this
study
exhibit
noteworthy
potential
foster
development
innovative
clinical
strategies
head
neck
carcinoma.
Язык: Английский
Applications of Matrix Metalloproteinase-9-Related Nanomedicines in Tumors and Vascular Diseases
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 479 - 479
Опубликована: Апрель 7, 2025
Matrix
metalloproteinase-9
(MMP-9)
is
implicated
in
tumor
progression
and
vascular
diseases,
contributing
to
angiogenesis,
metastasis,
extracellular
matrix
degradation.
This
review
comprehensively
examines
the
relationship
between
MMP-9
these
pathologies,
exploring
underlying
molecular
mechanisms
signaling
pathways
involved.
Specifically,
we
discuss
contribution
of
epithelial–mesenchymal
transition,
as
well
its
involvement
a
spectrum
including
macrovascular,
cerebrovascular,
ocular
diseases.
focuses
on
recent
advances
MMP-9-targeted
nanomedicine
strategies,
highlighting
design
application
responsive
nanoparticles
for
enhanced
drug
delivery.
These
nanotherapeutic
strategies
leverage
overexpression
achieve
targeted
release,
improved
penetration,
reduced
systemic
toxicity.
We
explore
various
nanoparticle
platforms,
such
liposomes
polymer
nanoparticles,
their
action,
degradation,
targeting
specificity.
Finally,
address
challenges
posed
by
heterogeneity
expression
implications
personalized
therapies.
Ultimately,
this
underscores
diagnostic
therapeutic
potential
nanomedicines
against
tumors
Язык: Английский
Neoadjuvant Hyperthermia Combined with Hybrid Nanoarchitectures Enhances Chemoradiotherapy Efficacy in Head and Neck Carcinoma
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(33), С. 43272 - 43282
Опубликована: Авг. 10, 2024
Head
and
neck
squamous
cell
carcinomas
are
characterized
by
a
high
incidence
of
recurrence,
especially
in
patients
with
locally
advanced
disease.
Standard
treatment
strategies
can
be
associated
severe
side
effects
to
healthy
tissues
that
negatively
impact
the
patient's
quality
life.
Hyperthermia
(HT)
is
noninvasive
modality
has
improved
effectiveness
chemotherapy
(CT)
and/or
radiotherapy
(RT)
for
management
some
solid
neoplasms.
In
this
context,
association
approach
rationally
designed
nanomaterials
may
further
enhance
outcome.
study,
we
demonstrate
enhanced
effect
neoadjuvant
HT
combination
hybrid
nanoarchitectures
enclosing
cisplatin
prodrug
(NAs-CisPt)
RT.
All
treatments
their
combinations
have
been
fully
evaluated
employing
standardized
chorioallantoic
membrane
tumor
models
HPV-negative
head
carcinoma.
An
tumor-shrinking
was
observed
administration
trimodal
(HT/NAs-CisPt/RT),
which
also
highlighted
significant
increase
apoptosis.
Our
findings
nanotechnology-based
CT
RT
certain
order
enhances
vivo
On
broader
basis,
study
paves
way
next
exploration
approaches
clinical
oral
cancer
based
on
innovative
strategies.
Язык: Английский
Invasiveness modulation of glioma cells by copper complex-loaded nanoarchitectures
Colloids and Surfaces B Biointerfaces,
Год журнала:
2024,
Номер
245, С. 114187 - 114187
Опубликована: Авг. 31, 2024
Among
the
tumors
with
highest
lethality,
gliomas
are
primary
brain
associated
common
recurrence
inclined
to
metastasize
along
neuraxis
and
occasionally
out
of
central
nervous
system.
Even
though
metastasis
is
main
responsible
for
death
in
oncological
patients,
few
dedicated
treatments
approved.
Therefore,
establishment
effective
anti-metastasis
agents
final
frontier
cancer
research.
Interestingly,
some
copper
complexes
have
demonstrated
promising
efficacy
as
antimetastatic
agents,
but
they
may
cause
off-site
effects
such
alteration
homeostasis
healthy
tissues.
Thus,
incorporation
copper-based
rationally
designed
nano-architectures
can
increase
treatment
localization
reducing
side
effects.
Here,
complex
loaded
hybrid
(CuLNAs)
presented
employed
assess
impact
an
intracellular
source
on
glioma
cell
invasiveness.
The
novel
CuLNAs
fully
characterized
exploited
migration
modulation
a
line.
results
demonstrate
that
significantly
reduce
without
impairing
proliferation
compared
standard
gold
NAs.
A
concomitant
antimigratory-like
regulation
epithelial-to-mesenchymal
transition
genes
confirmed
these
results,
gene
encoding
epithelial
protein
E-cadherin
was
upregulated
other
explored
mesenchymal
were
downregulated.
These
findings,
together
intrinsic
behaviors
NAs,
inclusion
metal
approach
composition
family
activity.
Язык: Английский