Journal of Tissue Engineering,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 1, 2025
Osteonecrosis
of
the
femoral
head
(ONFH)
is
a
prevalent
orthopedic
disorder
characterized
primarily
by
compromised
blood
supply.
This
vascular
deficit
results
in
cell
apoptosis,
trabecular
bone
loss,
and
structural
collapse
at
late
stage,
significantly
impairing
joint
function.
While
MRI
highly
effective
tool
for
diagnosing
ONFH
its
early
stages,
challenges
remain
due
to
limited
availability
high
cost
MRI,
as
well
absence
routine
screening
asymptomatic
patients.
.
In
addition,
current
therapeutic
strategies
predominantly
only
relieve
symptoms
while
disease-modifying
drugs
are
still
under
investigation/development.
Considering
that
supply
plays
key
role
pathology
ONFH,
angiogenic
therapies
have
been
put
forward
promising
treatment
options.
Emerging
bioengineering
interventions
targeting
angiogenesis
hold
potential
treatment.
this
review,
we
introduce
advances
research
into
summarize
novel
angiogenesis.
review
sheds
light
upon
new
directions
future
ONFH.
Advanced Materials,
Год журнала:
2025,
Номер
37(2)
Опубликована: Янв. 1, 2025
This
special
issue
spans
a
diverse
array
of
topics,
including
nanomedicine,
tissue
engineering,
regenerative
medicine,
organs-on-chips,
biosensing,
soft
robotics,
smart
devices,
nanofabrication,
energy
saving
and
storage,
catalysis,
spintronics,
electronics,
neuromorphic
computing.
It
showcases
the
breadth
depth
advanced
materials
research
at
Chinese
University
Hong
Kong
(CUHK),
highlighting
innovation,
collaboration,
excellence
CUHK's
scientists.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Metastasis
is
the
leading
cause
of
death
in
patients
with
lung
cancer.
Multidisciplinary
comprehensive
treatments
(MDT),
including
surgery,
chemotherapy,
radiotherapy,
gene-targeted
therapy,
immunotherapy,
antibody-drug
conjugate
(ADC),
natural
products,
etc.,
have
been
currently
used
for
cancer
metastasis.
The
MDT
model
has
shown
promising
efficacy
against
metastasis
clinical
practice.
However,
these
therapies
some
limitations,
such
as
unusual
toxic
side
effects,
drug
resistance,
limited
indications,
and
high
costs.
Therefore,
emerging
technological
platforms
are
imperative
to
overcome
bottlenecks.
Nanomedicine
can
be
prepare
efficient
delivery
systems
owing
its
good
biocompatibility,
targeting,
responsive
release,
multidrug
codelivery
plays
an
important
role
synergistic
antimetastasis
because
optical,
acoustic,
electrical,
thermal,
magnetic
functions.
This
review
analyses
limitations
model,
briefly
outlines
advantages
nanotechnology,
introduces
nanodrug
systems,
summarizes
nanostrategies
based
on
invasion-metastasis
cascade
process,
provides
a
summary
prospects
challenges
translation
nanomedicines.
E3S Web of Conferences,
Год журнала:
2024,
Номер
552, С. 01092 - 01092
Опубликована: Янв. 1, 2024
There
are
different
medical
applications
that
utilize
biomaterials
to
settle
tissues,
convey
drugs,
and
make
biomedical
devices.
This
paper
gives
a
relevant
analysis
of
talking
about
their
groupings,
highlights,
biocompatibility
issues,
variety
uses
or
applications.
The
separates
into
polymers,
ceramics,
metals,
composites
explaining
them
in
detail
with
focus
on
particular
traits
suit
indicated
purposes.
According
the
paper,
Polymers
adaptable
materials
can
be
utilized
as
scaffolds
for
tissue
engineering,
artificial
blood
vessels,
drug
carriers
aqueous
media.
On
ceramics
this
commonly
bone
replacement
material
due
extraordinary
mechanical
properties
bioactivity.
Basically,
all
such
tricalcium
phosphate
hydroxyapatite
have
had
higher
success
rates
because
high
mineral
substance
making
perfect
dental
implants.
Metals
like
titanium,
cobalt-chromium
alloys,
stainless
steel
found
wide
utilization
since
they
great
strength
erosion
resistance
which
is
frequently
required
end
osseous
As
result,
given
priority
biomaterial
design,
requirement
connect
safely
agreeably
natural
frameworks.
In
reality,
improvements
innovation
empowered
advancement
innovative
boost
through
strategies
surface
adjustments
bio-mimetic
coatings.
These
advancements
growth
sector
become
useful
industry.
Moreover,
clarifies
how
these
play
an
impactful
portion
devices
incorporates
catheters,
implantable
devices,
conveyance
systems,
orthopaedic
implants
among
others.
major
polymers
instruments
whereas
broadly
orthopaedics
dentistry
upgrades
recovery
Osseo
integration.
Similarly,
metals
well
known
ability,
biocompatibility,
substantial
existence
alongside
cardiovascular
Through
range
review
numerous
healthcare,
contribute
few
valuable
insights
concerning
will
shape
future
technology
persistent
care.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
Abstract
Chirality,
the
property
of
objects
that
are
nonsuperimposable
on
their
mirror
images,
plays
a
crucial
role
in
biological
processes
and
cellular
behaviors.
Chiral
engineered
biomaterials
have
emerged
as
promising
approach
to
regulating
fate
regenerative
medicine.
However,
few
reviews
provide
comprehensive
examination
recent
advancements
chiral
applications
regulation.
Herein,
various
fabrication
techniques
available
for
biomaterials,
including
use
molecules,
surface
patterning,
self‐assembly
discussed.
The
mechanisms
through
which
influence
responses,
such
modulation
adhesion
receptors,
intracellular
signaling,
gene
expression,
explored.
Notably,
demonstrated
ability
guide
stem
cell
differentiation
augment
tissue‐specific
functions.
potential
musculoskeletal
disorders,
neurodegenerative
diseases,
cardiovascular
wound
healing
highlighted.
Challenges
future
perspectives,
standardization
methods
translation
clinical
settings,
addressed.
In
conclusion,
offer
exciting
prospects
precisely
controlling
fate,
advancing
medicine,
enabling
personalized
therapeutic
strategies.
