Size Effect-based Improved Antioxidant Activity of Selenium Nanoparticles Regulating Anti-PI3K-mTOR and Ras-MEK Pathways for Treating Spinal Cord Injury to Avoid Hormone Shock-induced Immunosuppression DOI Creative Commons
Peixin Liu, Xiaodong Liu, Zihao Wu

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract Spinal cord injury (SCI) is a critical condition affecting the central nervous system that often has permanent and debilitating consequences, including secondary injuries. Oxidative damage inflammation are factors in pathological processes. Selenium nanoparticles have demonstrated significant antioxidative anti-inflammatory properties via non-immunosuppressive pathway; however, their clinical application been limited by inadequate stability functionality to cross blood-spinal barrier (BSCB). This study proposed synthesis method for ultra-small-diameter lentinan Se (LNT-UsSeNPs) with significantly superior reactive oxygen species (ROS) scavenging capabilities compared conventional (LNT-SeNPs). These compounds effectively protected PC-12 cells from oxidative stress-induced cytotoxicity, alleviated mitochondrial dysfunction, reduced apoptosis. In vivo studies indicated LNT-UsSeNPs efficiently penetrated BSCB inhibited apoptosis of spinal neurons. Ultimately, directly regulated PI3K-AKT-mTOR Ras-Raf-MEK-ERK signaling pathways regulating selenoproteins achieve therapy. Owing ultra-small size, exhibited strong penetration potent effects without compromising immune function. findings suggest promising candidates further development nanomedicine effective treatment SCI.

Язык: Английский

Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT axis DOI Creative Commons

Huizhen Xing,

Xueli Bai,

Xiaoying Pei

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 23, 2025

Язык: Английский

Процитировано

3
Microenvironment‐Activatable Probe for Precise NIR‐II Monitoring and Synergistic Immunotherapy in Rheumatoid Arthritis DOI Open Access
Yuan Zhang, Dongfang Liu, Wenwen Chen

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(48)

Опубликована: Окт. 6, 2024

Rheumatoid arthritis (RA) represents an insidious autoimmune inflammatory disorder that severely lowers the life quality by progressively destructing joint functions and eventually causing permanent disability, posing a serious public health problem. Here, advanced theranostic probe is introduced integrates activatable second near-infrared (NIR-II) fluorescence imaging for precise RA diagnosis with multi-pronged treatments. A novel molecular comprising long-wavelength aggregation-induced emission unit manganese carbonyl cage motif synthesized, which enables NIR-II activation concurrently releasing therapeutic carbon monoxide (CO) gas in inflamed microenvironment. This self-assembles into biocompatible nanoprobe, subsequently conjugated anti-IL-6R antibody to afford active-targeting ability of RA. The nanoprobe exhibits significant turn-on signal at lesion, enabling highly sensitive real-time monitoring. combination ROS scavenging, on-demand CO release, IL-6 signaling blockade results potent effect synergistic immunomodulation impact, significantly alleviating symptoms preventing destruction. research introduces paradigm development high-performance, strategies facilitate detection enhanced treatment RA-related diseases.

Язык: Английский

Процитировано

16
Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-induced immunosuppression DOI Creative Commons
Peixin Liu, Xiaodong Liu, Zihao Wu

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 16, 2025

Язык: Английский

Процитировано

2
Designing macrophage membrane-engineered ruthenium/selenium nanoparticles to block bone metastasis of breast cancer DOI

Meijin Yang,

Zhiying Tang,

M Kellis

и другие.

Nano Research, Год журнала: 2024, Номер 17(8), С. 7504 - 7512

Опубликована: Июнь 14, 2024

Язык: Английский

Процитировано

7
The Application of Selenium Nanoparticles in Immunotherapy DOI Creative Commons
Yu Yang, Ying Liu, Qingxia Yang

и другие.

Nano Biomedicine and Engineering, Год журнала: 2024, Номер 16(3), С. 345 - 356

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

7
Self‐Enhancing Drug Pair‐Driven Selenium Nanotherapeutics Reverses Microglial Pyroptosis Through NLRP3/Caspase‐1 Pathway and Neuronal Apoptosis for Treatment of Spinal Cord Injury DOI Open Access

Jinggong Liu,

Luo-Qi Mai,

Aaron C. Tan

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 23, 2025

Abstract Spinal cord injury (SCI) constitutes a critical occurrence that results in the disruption of both motor and sensory functions. Oxidative stress‐induced apoptosis pyroptosis have been identified as contributors to neuronal damage during secondary phase following SCI. Therefore, this study focuses on development self‐enhancing drug pair‐driven selenium (Se) nanotherapeutics, loading with 2,3,5,6‐tetramethylpyrazine (TMP) Ginsenoside Rg1 (Rg1), enhance treatment The engineered LET/TMP/Rg1@Se NPs exhibits remarkable antioxidant properties, effectively reducing oxidative by minimizing reactive oxygen species (ROS) accumulation restoring mitochondrial function. In addition their effects, nanotherapeutics demonstrates significant anti‐pyroptotic effects BV2 microglial cells modulating NLRP3/caspase‐1 pathway, leading decreased release pro‐inflammatory cytokines IL‐1β IL‐18. Moreover, inhibition inflammatory cascade response diminishes neuroinflammation‐induced promotes axonal regeneration neurons vitro. mouse model SCI, improved function regeneration, attributed pyroptosis, highlighting scientific basis for synergistic effect Se an innovative strategy effective SCI therapy.

Язык: Английский

Процитировано

1
Dual-Driven Selenium Janus Single-Atom Nanomotors for Autonomous Regulating Mitochondrial Oxygen Imbalance to Catalytic Therapy of Rheumatoid Arthritis DOI Creative Commons
Xu Chen, Yuan‐Han Yang, Jiajun Chen

и другие.

Redox Biology, Год журнала: 2025, Номер 81, С. 103574 - 103574

Опубликована: Март 1, 2025

O2 deficiency and excessive reactive oxygen nitrogen species (RONS) in macrophage mitochondria is a key factor causing imbalance rheumatoid arthritis microenvironment (RAM). Although nanocatalytic therapy that simultaneously produce eliminate RONS offer novel strategy for RA therapy, the therapeutic efficacy of nanozymes limited by lack autonomous targeting into mitochondria. Herein, we constructed Janus-structured nanomotor (Pd@MSe) with ability embedding Pd single-atom mesoporous selenium (MSe) nanozymes, obtained composite (Pd@MSe-TPP) dual-driven forces modifying triphenylphosphine (TPP) MSe hemisphere. In RAM, Pd@MSe-TPP achieved autonomously target macrophages driven generation TPP effect, moreover under effect enhanced electronic transfer between which significantly boosted GPx catalytic activity further effectively diffusion nanomotor, thus quickly resorted balance. Additionally, while regulating imbalance, enable rapidly blocked inflammatory cascade, restored mitochondrial function alleviated inflammation, prevented cartilage degradation inhibited progression. Therefore, exquisitely designed nanoplatform to regulation arthritic provides new direction clinical translation nanomedicine.

Язык: Английский

Процитировано

0
A Ubiquitin‐Competitive Strategy Based on the Element Microenvironment to Treat Osteoarthritis DOI
Keyu Kong, Yuqi Yang, Yongyun Chang

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 6, 2024

Abstract Recent research on ferroptosis and cuproptosis has underscored the crucial role of trace element regulation in osteoarthritis (OA) treatment. However, systematically addressing alterations nutrient elements OA cartilage is lacking. This study initiated using clinical specimens to quantify metal concentrations both damaged intact identify deficient within inflammatory senescent microenvironments OA. Based preliminary findings selenium (Se) gallium (Ga) deficiencies cartilage, tailored nanoparticles based Se Ga are designed validated for their antioxidant ability. GaSe x demonstrated significant efficacy mitigating chondrocyte degeneration extracellular matrix degradation induced by factors alleviating abrasion, hyperalgesia, abnormal gait a destabilization medial meniscus (DMM) mouse model. Mechanistically, activated Nrf2 pathway competitively inhibited ubiquitin‐mediated Gpx4, thus inhibiting ferroptosis. imbalance knee joint microenvironment robust capabilities remarkable competitive properties ubiquitin, thereby providing novel therapeutic solution

Язык: Английский

Процитировано

3
Multi-therapeutic-activity selenium nanodot toward preventing brain injury and restoring neurobehavioral functions following hemorrhagic stroke DOI Creative Commons

Yibin Zhang,

Xiaoyu Wang,

Xuegang Niu

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 14, 2024

Язык: Английский

Процитировано

3
Research progress on selenium system in cancer therapy: Focus on interface modifications and improvement of interactions DOI
Hui He,

Dingding Huang,

Peng Xie

и другие.

Surfaces and Interfaces, Год журнала: 2024, Номер unknown, С. 105642 - 105642

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

3