Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 1, 2025

Язык: Английский

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Self‐Cascade of ROS/Glucose‐Scavenging Immunomodulatory Hydrogels for Programmed Therapeutics of Infected Diabetic Ulcers via Nrf2/NF‐κB Pathway

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Diabetic ulcers (DUs) are characterized by a microenvironment with high oxidative stress, blood glucose levels, and recalcitrant bacterial infections. This is accompanied long‐term suppression of endogenous antioxidant systems, which makes their clinical management extremely challenging. To address this issue, hybridized novel gold‐palladium (AuPd) nanoshell the injectable/injectable hydrogel system UiO/AuPd shells /BNN6/PEG@Gel (UAPsBP@Gel) developed. The capable acting as nitric oxide (NO) reactor utilizing synergistic therapy that harnesses NIR‐II light‐triggered photothermal effects controlled release NO gas for treatment to eradicate biofilm infections at different depths. AuPd nanoshells exhibits superoxide dismutase (SOD)‐, oxidase (GOx)‐, catalase (CAT)‐like activities, enabling self‐cascade process scavenging both reactive oxygen species (ROS) glucose. activity reshapes DUs microenvironment, switches on Nrf2/HO‐1 pathway inhibits NF‐κB pathway, promotes macrophage polarization toward anti‐inflammatory M2 phenotype, reduces resulting in efficient immunomodulation. In vitro / vivo results demonstrate UAPsBP@Gel can multifacetedly enhance epithelial rejuvenation through wound hemostasis, pro‐cellular migration vascularization. These highlight programmed therapeutic based UBAPsP@Gel tailored stages infected meet complex needs.

Язык: Английский

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Macro/Microgel‐Encapsulated, Biofilm‐Armored Living Probiotic Platform for Regenerating Bacteria‐Infected Diabetic Wounds

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Abstract Infectious diabetic wounds pose an arduous threat to contemporary healthcare. The combination of refractory biofilms, persistent inflammation, and retarded angiogenesis can procure non‐unions life‐threatening complications, calling for advanced therapeutics potent orchestrate anti‐infective effectiveness, benign biocompatibility, pro‐reparative immunomodulation, angiogenic regeneration. Herein, embracing the emergent “living bacterial therapy” paradigm, a designer probiotic‐in‐hydrogel wound dressing platform is demonstrated. constructed employing “macrogel/microgel/biofilm” hierarchical encapsulation strategy, with Lactobacillus casei as model probiotic. Alginate gels, in both macro micro forms, along self‐produced probiotic served encapsulating agents. Specifically, live probiotics are enclosed within alginate microspheres, embedded into bulk matrix, cultivated facilitate biofilm self‐encasing. This multiscale confinement protected averted their inadvertent escape, while enabling sustained secretion, proper reservation, localized delivery therapeutically active metabolites, such lactic acid. resulting biosystem, validated vitro/ovo/vivo, elicited well‐balanced antibacterial activities biological compatibility, alongside prominent pro‐healing, vasculogenic anti‐inflammatory potencies, thus accelerating regeneration infected full‐thickness excisional mice. Such multiple encapsulation‐engineered “all‐in‐one” tactic may shed new light on safe efficient adoption bacteria treating chronic infectious diseases.

Язык: Английский

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Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing

Bioactive Materials, Год журнала: 2025, Номер 47, С. 266 - 282

Опубликована: Янв. 25, 2025

Язык: Английский

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NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication

Journal of Biological Engineering, Год журнала: 2025, Номер 19(1)

Опубликована: Фев. 5, 2025

The rise of antibiotic resistance has made bacterial infections a persistent global health issue. In particular, extracellular polymeric substances (EPS) secreted by bacteria limit the effectiveness conventional antibiotics, making biofilm removal challenging. To address this, we created ND@PDA nanoparticles coating surface nanodiamonds (ND) with polydopamine (PDA). These were then integrated into polyvinyl alcohol to fabricate PVA/ND@PDA nanofiber scaffolds, resulting in an innovative platform enhanced photothermal, antibacterial and antibiofilm properties. Upon exposure near-infrared (NIR) light, scaffolds exhibited significant photothermal activity, oxidative stress effectively damaging key components, such as biofilm, membranes, proteins. Additionally, catechol groups PDA provided strong cell adhesion high biocompatibility on surface. Our research proposes that not only addresses antibiotic-resistant but also contributes advancements wound healing therapies enabling controlled action minimal toxicity.

Язык: Английский

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Photo-Controlled extracellular electron transfer in Non-Extracellular respiratory bacteria by constructing a nanoscale interface material for energy transformation

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159553 - 159553

Опубликована: Янв. 1, 2025

Язык: Английский

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Fabrication of Multifunctional Three‐Component Supramolecular Nano‐Biscuits via Two Macrocycles‐Involved Self‐Assembly for Rice, Citrus and Kiwifruit Protections

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Abstract Bacterial plant diseases, worsened by biofilm‐mediated resistance, are increasingly threatening global food security. Numerous attempts have been made to develop agrochemicals that inhibit biofilms, however, their ineffective foliar deposition and difficulty in removing mature biofilms remain major challenges. Herein, multifunctional three‐component supramolecular nano‐biscuits (NI6R@CB[7]@ β ‐CD) successfully engineered via ordered self‐assembly between two macrocycles [cucurbit[7]uril (CB[7]), ‐cyclodextrin ( ‐CD)] R )‐2‐naphthol‐based bis‐imidazolium bromide salt (NI6R). This macrocycles‐involved bactericidal material combines many advantages. 1) Alleviate the off‐target movement of droplets on hydrophobic blade surfaces. 2) Enhance biofilm‐disrupting ability. At a low‐dose 4.44 µg mL −1 , inhibition rate biofilm formation reached 78.3%. 35.5 potency remove 77.6%. 3) Efficiently hinder bacterial reproduction, swimming, extracellular polysaccharide production, enzyme secretion, virulence plants. These superior characteristics undoubtedly transmitted vivo control effect. 200 this smart exhibits efficiencies 49.6%/65.0%/85.4% against three kinds diseases (rice leaf blight, citrus canker, kiwifruit canker), respectively, surpassing commercial bactericide—thiodiazole‐copper‐20%SC (33.6%/41.5%/43.2%) NI6R (40.3%/51.2%/71.2%). Furthermore, NI6R@CB[7]@ ‐CD is biosafe non‐target organisms. study instructive for constructing sustainable crop protection.

Язык: Английский

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The mussel-inspired GelMA/dopamine/hyaluronic acid composite hydrogel dressing for wet surface adhesion

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140448 - 140448

Опубликована: Янв. 1, 2025

Язык: Английский

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Bioengineered Versatile Heterojunctions as Stress Busters Targeting Matrix Degradation and Ferroptosis for Osteoarthritis Therapy

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Abstract Osteoarthritis (OA) is a chronic joint disease characterized by degeneration of articular cartilage, with the underlying mechanism being inability chondrocytes to maintain homeostasis in response changing stress. The stress triggered excess ROS from various factors critical regulating chondrocyte survival and fate. In this study, 2D Mo 4/3 B 2‐ X MBene cerium‐gallic acid metal‐polyphenol network (MPN) together cartilage‐targeted shell hyaluronic WYRGRL (HW) are utilized development bio‐heterojunction MBene@MPN‐HW (MBM‐HW) through self‐assembly. MBM‐HW not only demonstrates superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) enzyme mimicking capabilities effectively scavenge ROS, but also exhibits dual‐responsive release cartilage‐targeting properties. Importantly, both vivo vitro experiments indicate that could alleviate oxidative stress, protect mitochondrial function, suppress cartilage matrix ferroptosis, thereby slowing progression OA. Mechanistically, it demonstrated attenuate Perk/eIF2α cascade mediated integrated restrain maintaining homeostasis. Overall, work underscores robust stress‐relieving capacity MBM‐HW, providing novel approach for treatment

Язык: Английский

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Engineered Bdellovibrio bacteriovorus enhances antibiotic penetration and biofilm eradication

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 283 - 296

Опубликована: Фев. 6, 2025

Язык: Английский

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