Dual Vacancies‐Engineered Two‐Dimensional Sonocatalysts for Ultrasound‐Augmented and PANoptosis‐Driven Catalytic Tumor Nanotherapy DOI Creative Commons
Tianming Xu, Xinran Song, Meiqi Chang

et al.

Interdisciplinary materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

ABSTRACT Regulated cell death (RCD) is considered a vital process in cancer therapy, determining treatment outcomes and facilitating the eradication of cells. As an emerging type RCD, PANoptosis features excellent antineoplastic effects due to its combination modes, including pyroptosis, apoptosis, necroptosis. In this work, anion‐cation vacancies (oxygen/titanium‐vacancy‐rich) ultrathin HTiO nanosheets with outstanding sonocatalytic performance peroxidase‐mimicking activity are rationally engineered for disruption mitochondrial function tumor cells destabilization redox homeostasis, ultimately inducing PANoptosis. The utilization external ultrasound energy amplifies production toxic reactive oxygen species (ROS). Density functional theory calculations indicate that titanium generated enhance ROS generation efficiency by promoting carrier separation increasing adsorption capacity H 2 O . advantages triggering substantially evidenced exceptional efficacy both at cellular level on two vivo separate xenografts (4T1 MDA‐MB‐231 breast tumors). This work highlights distinct titanium‐based nanostructure multimodal synergistic integration enzymatic therapies, offering alternative but highly efficient strategy fabricating vacancy‐engineered biomaterials optimized therapeutic treatment.

Language: Английский

A strategy of “adding fuel to the flames” enables a self-accelerating cycle of ferroptosis-cuproptosis for potent antitumor therapy DOI
Lin Huang,

Jiaoyang Zhu,

Guochao Wu

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122701 - 122701

Published: July 6, 2024

Language: Английский

Citations

29
Copper‐Based Bio‐Coordination Nanoparticle for Enhanced Pyroptosis‐Cuproptosis Cancer Immunotherapy through Redox Modulation and Glycolysis Inhibition DOI Open Access

Ju‐E Cun,

Ziyun He,

Fan Xi

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Copper-based nanoparticles have garnered significant interest in cancer therapy due to their ability induce oxidative stress and cuproptosis cells. However, antitumor effectiveness is constrained by the dynamic redox balance metabolic shift between phosphorylation glycolysis. Here, a polydopamine-coated copper-α-ketoglutaric acid (α-KG) coordination polymer nanoparticle (CKPP) designed for combined pyroptosis-cuproptosis immunotherapy amplifying reactive oxygen species (ROS) production regulating cellular metabolism. The intracellular imbalance achieved through synergistic effects of α-KG-induced mitochondrial reprogramming, photothermally enhanced superoxide dismutase-like activity polydopamine, glutathione depletion copper ions. multifaceted modulation results substantial increase ROS levels, triggering subsequent pyroptosis Furthermore, α-KG shifts metabolism from glycolysis phosphorylation, thereby enhancing induced combination dyshomeostasis inhibition potent enhancement pyroptosis-cuproptosis-mediated therapy. In murine model colorectal cancer, CKPP exhibited remarkable anticancer effect, achieving tumor rate 96.3% complete eradication two out five cases. Overall, this bio-engineered metal-organic nanocomposite demonstrates potential treating immunotherapy.

Language: Английский

Citations

4
Tumor microenvironment-activated and near-infrared light-driven free radicals amplifier for tetra-modal cancer imaging and synergistic treatment DOI
Yadi Fan, Jingyu Shi, Ruolin Zhang

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 689, P. 137208 - 137208

Published: March 1, 2025

Language: Английский

Citations

3
Revolutionary Energy Harvesting: Gravity‐Driven Piezocatalysts for Sustainable Hydrogen Production in MoS2@Mo2CTx Systems DOI

Hsun‐Yen Lin,

Jyh Ming Wu

Advanced Energy Materials, Journal Year: 2024, Volume and Issue: 14(39)

Published: July 11, 2024

Abstract Hydrogen (H 2 ) is mainly produced using steam methane reforming, electrolysis, and gasification, which require external energy special catalysts. A new catalyst by combining MoS nanoflowers (NFs) with metal carbide/nitride nanosheets (Mo CTx MXene) to create a nanosheet bending moment. The @Mo CT x heterostructures achieve production rate of 1164.8 µmol g −1 h under an application mechanical force, 4.01 3.06 times higher than Mo alone, due enhanced charge transfer from 's piezoelectricity conductivity. This study introduces pioneering methodology that harnesses gravitational as continuous simulated peristaltic pump, drive the piezocatalytic hydrogen evolution reaction (HER), achieving notable 454.1 over 24 hours demonstrating sustained capability for generation. theoretical calculation results validate piezoelectric potential in water‐flow‐pressure triggered HER systems. system, assuming powered Hoover Dam, will produce 290.9 kmoles per ton daily, equivalent utilizing 19 150 kWh electrocatalytic system. gravity‐driven water flow piezocatalysts H generation demonstrates superior efficiency eliminating common thermal conversion losses, marking significant breakthrough sustainable technologies.

Language: Английский

Citations

10
Synergistic photothermal and chemo-therapeutic platform utilizing Cu2-xSe/PDA/AIPH nanoparticles for targeted tumor eradication DOI
Haoyan Cheng,

Beng Ma,

Wanting Xia

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 169, P. 214196 - 214196

Published: Jan. 19, 2025

Language: Английский

Citations

2
Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy DOI
Yuanying Yang, Chen Dong, Xuehua Ma

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.

Language: Английский

Citations

2
Decreasing the aggregation of photosensitizers to facilitate energy transfer for improved photodynamic therapy DOI
Zhenhua Wang,

Jian‐Yang Ao,

Xing Lai

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

HA-TPP NHs constructed by chemical crosslinking fixing photosensitizers for reducing the aggregation of produce more singlet oxygen and have a better killing effect on tumor cells, compared to assembling NPs.

Language: Английский

Citations

1
Mesoporous dual-atom nanozyme induced cuproptosis and apoptosis for boosting immunogenic cell death along with reprogramming tumor immune-suppressive microenvironment DOI
Yunhao Wang, Lei Ding, Zhan Lin

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 160294 - 160294

Published: Jan. 1, 2025

Language: Английский

Citations

1
Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics DOI Creative Commons
Hongwei Bai, Sujun Ding,

Yanfei Dai

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Piezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the complexities of microenvironment. In this study, sulfur vacancy‐engineered cobalt (Co) single‐atom doped molybdenum disulfide (SA‐Co@MoS 2 ) nanoflowers are strategically designed, which exhibit enhanced effects. Specifically, introduction Co single atom not only induces lattice distortion out‐of‐plane polarization but also leads to formation numerous vacancies. These changes collectively narrow intrinsic bandgap material, facilitating effective separation migration charge carriers, enabling efficient production reactive oxygen species under ultrasound stimulation. Additionally, SA‐Co@MoS demonstrate improved enzymatic activity glutathione depletion capabilities attributed mixed valence states Co, intensifying oxidative stress cells, leading cell cycle arrest apoptosis, while inactivation peroxidase 4 ferroptosis. Both vitro vivo results indicate that can significantly eliminate cells. This study offers valuable insights into exploration doping‐enhanced sonosensitizers for cancer treatment, potentially paving way advancements field synergistic enzyodynamic therapy.

Language: Английский

Citations

1
Single-atom–doped piezocatalyst induces copper-free cuproptosis in tumor therapy DOI Creative Commons
M. Zhang, Xinran Song, Yu Qin

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(7)

Published: Feb. 14, 2025

Cuproptosis, a distinct cell death pathway, has been integrated into nanomedicine for disease theranostics. However, current nanosystems inducing cuproptosis rely on exogenous toxic copper ions, limiting the scope of biomaterials. Developing nanoplatforms that induce without holds substantial promise. Here, we engineered two-dimensional iron (Fe) single-atom–doped molybdenum disulfide (MoS 2 ) piezocatalyst (Fe-MoS tumor therapy. Incorporating single Fe atoms enhances MoS piezoelectric polarization via charge redistribution and modulates Mo oxidation states, enabling multifaceted enzymatic activities, including peroxidase-, glutathione oxidase–, oxidase-, catalase-like activities. Upon ultrasound stimulation, Fe-MoS nanocatalyst generates reactive oxygen species depletes synergistic piezocatalytic enzyocatalytic effects, disrupting ion homeostasis cuproptosis, concurrently triggering ferroptosis ferritinophagy, which collectively suppression. This study represents first paradigm to introduce copper-free initiating substantially advancing applications in

Language: Английский

Citations

1