Construction of a Biomimetic Tubular Scaffold Inspired by Sea Sponge Structure: Sponge‐Like Framework and Cell Guidance DOI Creative Commons
Si Meng,

Nihuan Wu,

Jie Fang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Engineering hollow fibers with precise surface microstructures is challenging; yet, essential for guiding cells alignment and ensuring proper vascular tissue function. Inspired by Euplectella sponges, a novel strategy to engineer biomimetic spiral developed. Using oxidized bacterial cellulose, polydopamine, "brick-and-mortar" scaffold created through shear control during microfluidic coaxial spinning. The mimics natural extracellular matrices, providing mechanical stability supporting cell growth. In vitro studies show successful co-culture of endothelial (ECs) smooth muscle (SMCs), SMCs aligning along ECs forming confluent inner layer. vivo implantation confirms biocompatibility, biodegradability, low immunogenicity. This Euplectella-inspired presents promising approach engineering regenerative medicine.

Language: Английский

Personalized bioceramic grafts for craniomaxillofacial bone regeneration DOI Creative Commons
Ana Beatriz Gomes de Carvalho, Maedeh Rahimnejad, Rodrigo L.M.S. Oliveira

et al.

International Journal of Oral Science, Journal Year: 2024, Volume and Issue: 16(1)

Published: Oct. 31, 2024

Abstract The reconstruction of craniomaxillofacial bone defects remains clinically challenging. To date, autogenous grafts are considered the gold standard but present critical drawbacks. These shortcomings have driven recent research on to focus synthetic with distinct materials and fabrication techniques. Among various methods, additive manufacturing (AM) has shown significant clinical potential. AM technologies build three-dimensional (3D) objects personalized geometry customizable from a computer-aided design. layer-by-layer 3D biomaterial structures can support formation by guiding cell migration/proliferation, osteogenesis, angiogenesis. Additionally, these be engineered degrade concomitantly new tissue formation, making them ideal as grafts. This review delves into key advances bioceramic grafts/scaffolds obtained printing for reconstruction. In this regard, relevant topics such ceramic-based biomaterials, graft/scaffold characteristics (macro/micro-features), material extrusion-based printing, step-by-step workflow engineer discussed. Importantly, in vitro models highlighted conjunction thorough examination signaling pathways reported when investigating bioceramics their effect cellular response/behavior. Lastly, we summarize potential translation opportunities regeneration.

Language: Английский

Citations

12
Application and progress of 3D printed biomaterials in osteoporosis DOI Creative Commons
Chenxu Wang, Aiguo Liu, Ziwen Zhao

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 4, 2025

Osteoporosis results from a disruption in skeletal homeostasis caused by an imbalance between bone resorption and formation. Conventional treatments, such as pharmaceutical drugs hormone replacement therapy, often yield suboptimal are frequently associated with side effects. Recently, biomaterial-based approaches have gained attention promising alternatives for managing osteoporosis. This review summarizes the current advancements 3D-printed biomaterials designed osteoporosis treatment. The benefits of compared to traditional systemic drug therapies discussed. These materials can be broadly categorized based on their functionalities, including promoting osteogenesis, reducing inflammation, exhibiting antioxidant properties, inhibiting osteoclast activity. 3D printing has advantages speed, precision, personalization, etc. It is able satisfy requirements irregular geometry, differentiated composition, multilayered structure articular osteochondral scaffolds boundary layer structure. limitations existing critically analyzed future directions considered.

Language: Английский

Citations

2
Advancements in 3D Printing Technologies for Personalized Treatment of Osteonecrosis of the Femoral Head DOI Creative Commons
Tingting Chen,

Lincong Luo,

Jiaying Li

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101531 - 101531

Published: Feb. 5, 2025

Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on innovative application of 3D addressing challenges osteonecrosis femoral head (ONFH). Unlike traditional hip replacement surgery, which is often suboptimal for younger patients, offers precise localization necrotic areas ability to create personalized implants. By integrating advanced biomaterials, this a promising strategy approach early hip-preserving treatments. Additionally, 3D-printed bone engineering scaffolds can mimic natural environment, promoting regeneration vascularization. In future, potential extends combining with artificial intelligence optimizing treatment plans, developing materials enhanced bioactivity compatibility, translating these innovations from laboratory clinical practice. demonstrates how uniquely addresses critical ONFH treatment, including insufficient vascularization, poor mechanical stability, limited long-term success conventional therapies. introducing gradient porous scaffolds, bioactive material coatings, AI-assisted design, work outlines novel strategies improve interventions. These advancements not only enhance efficacy but also pave way findings into applications.

Language: Английский

Citations

2
Piezoelectric materials for bone implants: opportunities and challenges DOI

Xionggang Chen,

Shiping Zhang, Shun Peng

et al.

Nano Energy, Journal Year: 2025, Volume and Issue: unknown, P. 110841 - 110841

Published: March 1, 2025

Language: Английский

Citations

2
Fabrication of a Whitlockite/PLGA Scaffold with Hierarchical Porosity for Bone Repair DOI
Cai‐Feng Wang, Ruofei Zhang, Ki‐Jae Jeong

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Regenerating functional bone tissue in critical-sized defects remains a formidable issue. Bone-tissue engineering (BTE) scaffolds are emerging as potential alternatives to transplantation for the repair of defects. However, developing BTE with unique bone-healing properties and natural porous structure is challenging. Herein, we presented biomimetic scaffold hierarchical porosity via solvent casting/particulate leaching method. The comprises osteoinductive whitlockite (WH) nanoparticles evenly dispersed poly(lactic-co-glycolic acid) (PLGA) matrix. Highly interconnected pores variations present scaffold, enabling superior solution diffusion compressive strength. Notably, WH/PLGA effectively promoted osteoblast differentiation vitro induced formation rat tibia defects, surpassing performance both hydroxyapatite (HAP)/PLGA PLGA scaffold. This study provides low-cost, facile, scalable strategy fabricating favorable mechanical properties, biocompatibility, capability.

Language: Английский

Citations

2
3D printed 2D materials for tissue engineering applications DOI Creative Commons
Muhammad Bagas Ananda, Maradhana Agung Marsudi, Indra Jaya Budiarso

et al.

ChemPhysMater, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Structural evolution of Sr-phosphate chemical conversion coatings induced by in-situ Ca doping to achieve efficient osteogenic activity DOI
Kangqing Zuo, Wenliang Lei, Qun Cao

et al.

Applied Surface Science, Journal Year: 2025, Volume and Issue: unknown, P. 162591 - 162591

Published: Jan. 1, 2025

Language: Английский

Citations

1
Implant coating for promoted postoperative bone regeneration via cascade Reaction-Mediated microenvironment reprogramming DOI
Bing Yan,

Rurong Lin,

C. X. Qiu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160557 - 160557

Published: Feb. 1, 2025

Language: Английский

Citations

1
Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration DOI Creative Commons
Hongjian Zhang, Ziyi Zhao, Chengtie Wu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated still poses significant challenges due lack concerns innervation. Design rationale multifunctional biomaterials both tissue-induction and neural induction activities shows great potential regeneration. Recently, research application inorganic attracts increasing attention in innervated multi-tissue such as central nerves, bone, skin, because its superior tunable chemical composition, topographical structures, physiochemical properties. More importantly, easily combined other organic materials, biological factors, external stimuli enhance their effects. This review presents a comprehensive overview recent advancements It begins introducing classification properties typical design inorganic-based material composites. Then, progresses regenerating various nerves nerve-innervated systematically reviewed. Finally, existing future perspectives proposed. may pave way direction offers new strategy regeneration combination

Language: Английский

Citations

1
Development of Bioorthogonally Degradable Tough Hydrogels Using Enamine N‐Oxide Based Crosslinkers DOI Creative Commons

T. Kim,

Deep Malu, Dongjing He

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Inducibly degradable polymers present new opportunities to integrate tough hydrogels into a wide range of biomaterials. Rapid and inducible degradation enables fast transition in material properties without sacrificing integrity prior removal. In pursuit bioorthogonal chemical modalities that will enable polymer biologically relevant environments, enamine N ‐oxide crosslinkers are developed for double network acrylamide‐based polymer/alginate hydrogels. Bioorthogonal dissociation initiated by the application aqueous diboron solution through several delivery mechanisms effectively lead degradation. Their B 2 (OH) 4 results fracture energy half‐life <10 min. The biocompatibility reagent is assessed, removability strongly adhered on mice skin evaluated. Thermoresponsive PNiPAAm/Alg fabricated as chemically intraoral wound dressing demonstrated. It demonstrated vivo maximum tolerated dose studies administered oral gavage well tolerated. Successful integration ‐oxides within motifs demonstrates applicability realm chemistry highlights importance induced reactions materials science.

Language: Английский

Citations

1