Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
Engineering
hollow
fibers
with
precise
surface
microstructures
is
challenging;
yet,
essential
for
guiding
cells
alignment
and
ensuring
proper
vascular
tissue
function.
Inspired
by
Euplectella
sponges,
a
novel
strategy
to
engineer
biomimetic
spiral
developed.
Using
oxidized
bacterial
cellulose,
polydopamine,
"brick-and-mortar"
scaffold
created
through
shear
control
during
microfluidic
coaxial
spinning.
The
mimics
natural
extracellular
matrices,
providing
mechanical
stability
supporting
cell
growth.
In
vitro
studies
show
successful
co-culture
of
endothelial
(ECs)
smooth
muscle
(SMCs),
SMCs
aligning
along
ECs
forming
confluent
inner
layer.
vivo
implantation
confirms
biocompatibility,
biodegradability,
low
immunogenicity.
This
Euplectella-inspired
presents
promising
approach
engineering
regenerative
medicine.
International Journal of Oral Science,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Oct. 31, 2024
Abstract
The
reconstruction
of
craniomaxillofacial
bone
defects
remains
clinically
challenging.
To
date,
autogenous
grafts
are
considered
the
gold
standard
but
present
critical
drawbacks.
These
shortcomings
have
driven
recent
research
on
to
focus
synthetic
with
distinct
materials
and
fabrication
techniques.
Among
various
methods,
additive
manufacturing
(AM)
has
shown
significant
clinical
potential.
AM
technologies
build
three-dimensional
(3D)
objects
personalized
geometry
customizable
from
a
computer-aided
design.
layer-by-layer
3D
biomaterial
structures
can
support
formation
by
guiding
cell
migration/proliferation,
osteogenesis,
angiogenesis.
Additionally,
these
be
engineered
degrade
concomitantly
new
tissue
formation,
making
them
ideal
as
grafts.
This
review
delves
into
key
advances
bioceramic
grafts/scaffolds
obtained
printing
for
reconstruction.
In
this
regard,
relevant
topics
such
ceramic-based
biomaterials,
graft/scaffold
characteristics
(macro/micro-features),
material
extrusion-based
printing,
step-by-step
workflow
engineer
discussed.
Importantly,
in
vitro
models
highlighted
conjunction
thorough
examination
signaling
pathways
reported
when
investigating
bioceramics
their
effect
cellular
response/behavior.
Lastly,
we
summarize
potential
translation
opportunities
regeneration.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: Feb. 4, 2025
Osteoporosis
results
from
a
disruption
in
skeletal
homeostasis
caused
by
an
imbalance
between
bone
resorption
and
formation.
Conventional
treatments,
such
as
pharmaceutical
drugs
hormone
replacement
therapy,
often
yield
suboptimal
are
frequently
associated
with
side
effects.
Recently,
biomaterial-based
approaches
have
gained
attention
promising
alternatives
for
managing
osteoporosis.
This
review
summarizes
the
current
advancements
3D-printed
biomaterials
designed
osteoporosis
treatment.
The
benefits
of
compared
to
traditional
systemic
drug
therapies
discussed.
These
materials
can
be
broadly
categorized
based
on
their
functionalities,
including
promoting
osteogenesis,
reducing
inflammation,
exhibiting
antioxidant
properties,
inhibiting
osteoclast
activity.
3D
printing
has
advantages
speed,
precision,
personalization,
etc.
It
is
able
satisfy
requirements
irregular
geometry,
differentiated
composition,
multilayered
structure
articular
osteochondral
scaffolds
boundary
layer
structure.
limitations
existing
critically
analyzed
future
directions
considered.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101531 - 101531
Published: Feb. 5, 2025
Three-dimensional
(3D)
printing
technology
has
shown
significant
promise
in
the
medical
field,
particularly
orthopedics,
prosthetics,
tissue
engineering,
and
pharmaceutical
preparations.
This
review
focuses
on
innovative
application
of
3D
addressing
challenges
osteonecrosis
femoral
head
(ONFH).
Unlike
traditional
hip
replacement
surgery,
which
is
often
suboptimal
for
younger
patients,
offers
precise
localization
necrotic
areas
ability
to
create
personalized
implants.
By
integrating
advanced
biomaterials,
this
a
promising
strategy
approach
early
hip-preserving
treatments.
Additionally,
3D-printed
bone
engineering
scaffolds
can
mimic
natural
environment,
promoting
regeneration
vascularization.
In
future,
potential
extends
combining
with
artificial
intelligence
optimizing
treatment
plans,
developing
materials
enhanced
bioactivity
compatibility,
translating
these
innovations
from
laboratory
clinical
practice.
demonstrates
how
uniquely
addresses
critical
ONFH
treatment,
including
insufficient
vascularization,
poor
mechanical
stability,
limited
long-term
success
conventional
therapies.
introducing
gradient
porous
scaffolds,
bioactive
material
coatings,
AI-assisted
design,
work
outlines
novel
strategies
improve
interventions.
These
advancements
not
only
enhance
efficacy
but
also
pave
way
findings
into
applications.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Tissue
engineering
aims
to
repair
damaged
tissues
with
physiological
functions
recovery.
Although
several
therapeutic
strategies
are
there
for
tissue
regeneration,
the
functional
recovery
of
regenerated
still
poses
significant
challenges
due
lack
concerns
innervation.
Design
rationale
multifunctional
biomaterials
both
tissue-induction
and
neural
induction
activities
shows
great
potential
regeneration.
Recently,
research
application
inorganic
attracts
increasing
attention
in
innervated
multi-tissue
such
as
central
nerves,
bone,
skin,
because
its
superior
tunable
chemical
composition,
topographical
structures,
physiochemical
properties.
More
importantly,
easily
combined
other
organic
materials,
biological
factors,
external
stimuli
enhance
their
effects.
This
review
presents
a
comprehensive
overview
recent
advancements
It
begins
introducing
classification
properties
typical
design
inorganic-based
material
composites.
Then,
progresses
regenerating
various
nerves
nerve-innervated
systematically
reviewed.
Finally,
existing
future
perspectives
proposed.
may
pave
way
direction
offers
new
strategy
regeneration
combination
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Abstract
Inducibly
degradable
polymers
present
new
opportunities
to
integrate
tough
hydrogels
into
a
wide
range
of
biomaterials.
Rapid
and
inducible
degradation
enables
fast
transition
in
material
properties
without
sacrificing
integrity
prior
removal.
In
pursuit
bioorthogonal
chemical
modalities
that
will
enable
polymer
biologically
relevant
environments,
enamine
N
‐oxide
crosslinkers
are
developed
for
double
network
acrylamide‐based
polymer/alginate
hydrogels.
Bioorthogonal
dissociation
initiated
by
the
application
aqueous
diboron
solution
through
several
delivery
mechanisms
effectively
lead
degradation.
Their
B
2
(OH)
4
results
fracture
energy
half‐life
<10
min.
The
biocompatibility
reagent
is
assessed,
removability
strongly
adhered
on
mice
skin
evaluated.
Thermoresponsive
PNiPAAm/Alg
fabricated
as
chemically
intraoral
wound
dressing
demonstrated.
It
demonstrated
vivo
maximum
tolerated
dose
studies
administered
oral
gavage
well
tolerated.
Successful
integration
‐oxides
within
motifs
demonstrates
applicability
realm
chemistry
highlights
importance
induced
reactions
materials
science.