Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 20, 2024
Abstract
Radiotherapy‐induced
ferroptosis
is
accompanied
by
an
adaptive
response
to
the
expression
of
tumor
cell
suppressor
genes.
Herein,
a
degradable
and
in
situ
generated
silicomanganese
composite
system
loaded
with
carbonic
anhydrase
(CA
IX)
inhibitor
(4‐(2‐aminoethyl)
benzenesulfonamide
(ABS)
constructed
form
DSiMn‐ABS
nanosystem
improve
sensitivity
hypoxic
cells
radiotherapy
effect.
The
can
be
continuously
degraded
environment
X‐rays,
releasing
Manganese
dioxid
（MnO
2
)and
ABS;
Thereby
inhibiting
activity
CA
IX,
inducing
acidification
inside
cells,
regulating
AMP‐activating
protein
kinase
(AMPK)/Acetyl‐CoA
carboxylase(ACC)
axis
increase
ferroptosis,
depleting
glutathione
(GSH)
through
MnO
influencing
peroxidase
4
(GPX4)
activity,
which
further
inhibits
defense
ultimately
effectively
improves
therapeutic
efficiency
radiotherapy.
Ultimately,
inhibit
growth.
Therefore,
this
utilize
double‐sensitized
provide
new
ideas
for
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(42), С. 23008 - 23023
Опубликована: Окт. 14, 2024
The
demand
for
food
has
increased
dramatically
as
the
global
population
increases,
putting
more
strain
on
sustainability
of
agriculture.
To
fulfill
this
requirement,
it
is
imperative
to
develop
brand-new
technologies.
application
potential
nanozymes
in
plant
and
environmental
sectors
progressively
becoming
apparent
a
result
their
effective
enzymatic
catalytic
activity
distinctive
characteristics
nanomaterials,
including
size,
specific
surface
area,
optical
properties,
thermal
properties.
Herein,
we
systematically
analyze
mechanisms
with
different
enzyme-mimetic
activities
summarize
applications
improving
crop
yields
by
regulating
ROS
levels
enhancing
stress
resistance
detecting
removing
hazardous
pollutants.
Finally,
thoroughly
challenges
faced
regarding
design,
application,
economy,
biosafety
look
forward
future
development
directions
better
serve
sustainable
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 20, 2024
Abstract
Radiotherapy‐induced
ferroptosis
is
accompanied
by
an
adaptive
response
to
the
expression
of
tumor
cell
suppressor
genes.
Herein,
a
degradable
and
in
situ
generated
silicomanganese
composite
system
loaded
with
carbonic
anhydrase
(CA
IX)
inhibitor
(4‐(2‐aminoethyl)
benzenesulfonamide
(ABS)
constructed
form
DSiMn‐ABS
nanosystem
improve
sensitivity
hypoxic
cells
radiotherapy
effect.
The
can
be
continuously
degraded
environment
X‐rays,
releasing
Manganese
dioxid
（MnO
2
)and
ABS;
Thereby
inhibiting
activity
CA
IX,
inducing
acidification
inside
cells,
regulating
AMP‐activating
protein
kinase
(AMPK)/Acetyl‐CoA
carboxylase(ACC)
axis
increase
ferroptosis,
depleting
glutathione
(GSH)
through
MnO
influencing
peroxidase
4
(GPX4)
activity,
which
further
inhibits
defense
ultimately
effectively
improves
therapeutic
efficiency
radiotherapy.
Ultimately,
inhibit
growth.
Therefore,
this
utilize
double‐sensitized
provide
new
ideas
for
