X‐Ray‐Triggered CA IX Inhibition Nanoplatform Promotes Intratumoral Acidosis‐Induced Cancer Ferroptosis DOI

Yuanyuan You,

Wenxiao Jiang, Renhao Xu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Radiotherapy‐induced ferroptosis is accompanied by an adaptive response to the expression of tumor cell suppressor genes. Herein, a degradable and in situ generated silicomanganese composite system loaded with carbonic anhydrase (CA IX) inhibitor (4‐(2‐aminoethyl) benzenesulfonamide (ABS) constructed form DSiMn‐ABS nanosystem improve sensitivity hypoxic cells radiotherapy effect. The can be continuously degraded environment X‐rays, releasing Manganese dioxid （MnO 2 )and ABS; Thereby inhibiting activity CA IX, inducing acidification inside cells, regulating AMP‐activating protein kinase (AMPK)/Acetyl‐CoA carboxylase(ACC) axis increase ferroptosis, depleting glutathione (GSH) through MnO influencing peroxidase 4 (GPX4) activity, which further inhibits defense ultimately effectively improves therapeutic efficiency radiotherapy. Ultimately, inhibit growth. Therefore, this utilize double‐sensitized provide new ideas for

Language: Английский

X‐Ray‐Triggered CA IX Inhibition Nanoplatform Promotes Intratumoral Acidosis‐Induced Cancer Ferroptosis DOI

Yuanyuan You,

Wenxiao Jiang, Renhao Xu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Radiotherapy‐induced ferroptosis is accompanied by an adaptive response to the expression of tumor cell suppressor genes. Herein, a degradable and in situ generated silicomanganese composite system loaded with carbonic anhydrase (CA IX) inhibitor (4‐(2‐aminoethyl) benzenesulfonamide (ABS) constructed form DSiMn‐ABS nanosystem improve sensitivity hypoxic cells radiotherapy effect. The can be continuously degraded environment X‐rays, releasing Manganese dioxid （MnO 2 )and ABS; Thereby inhibiting activity CA IX, inducing acidification inside cells, regulating AMP‐activating protein kinase (AMPK)/Acetyl‐CoA carboxylase(ACC) axis increase ferroptosis, depleting glutathione (GSH) through MnO influencing peroxidase 4 (GPX4) activity, which further inhibits defense ultimately effectively improves therapeutic efficiency radiotherapy. Ultimately, inhibit growth. Therefore, this utilize double‐sensitized provide new ideas for

Language: Английский

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