Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 25, 2024
Abstract
The
infected
chronic
wound
area
has
a
unique
microenvironment
featuring
hypoxia,
excessive
reactive
oxygen
species
(ROS),
and
inflammatory
conditions.
Bacteria‐formed
biofilms
limit
the
anti‐inflammation
efficiency
of
most
therapeutics
by
hindering
their
penetration
into
deep
tissues
increasing
drug
resistance.
unitary
modulation
pro‐inflammatory
M1
macrophage
polarization
cannot
relieve
inflammation
immediately.
Here,
“all
in
one”
folic
acid‐modified
small
organic
molecule‐based
nanoparticles
(2TT‐
m
C6B@CeO
2
@FA,
PCFs)
are
developed,
which
possess
dual‐targeting
to
bacteria
macrophages,
double
photothermal
therapy
(PTT),
enzymatic‐like
activities.
Based
on
considerable
catalase‐
superoxide
dismutase‐like
activities,
PCFs
can
efficiently
scavenge
ROS
produce
(O
).
generated
O
automatically
drive
movement
as
nanomotors
further
promote
rescue
hypoxia.
scavenging
promotes
macrophages
polarized
anti‐inflammatory
M2
macrophages.
study
also
identifies
that
FA‐modified
target
selectively
eliminate
through
PTT,
relieves
healing.
Transcriptome
analysis
confirms
inhibit
expression
inflammatory‐related
genes
while
cytokines.
In
vivo
experiments
identify
benefit
neovascularization
neonatal
tissue
generation
at
sites.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Авг. 13, 2024
Abstract
The
eye,
a
complex
organ
isolated
from
the
systemic
circulation,
presents
significant
drug
delivery
challenges
owing
to
its
protective
mechanisms,
such
as
blood-retinal
barrier
and
corneal
impermeability.
Conventional
administration
methods
often
fail
sustain
therapeutic
levels
may
compromise
patient
safety
compliance.
Polysaccharide-based
microneedles
(PSMNs)
have
emerged
transformative
solution
for
ophthalmic
delivery.
However,
comprehensive
review
of
PSMNs
in
ophthalmology
has
not
been
published
date.
In
this
review,
we
critically
examine
synergy
between
polysaccharide
chemistry
microneedle
technology
enhancing
ocular
We
provide
thorough
analysis
PSMNs,
summarizing
design
principles,
fabrication
processes,
addressed
during
fabrication,
including
improving
comfort
also
describe
recent
advances
performance
various
both
research
clinical
scenarios.
Finally,
current
regulatory
frameworks
market
barriers
that
are
relevant
commercial
advancement
final
perspective
on
area.
Chemistry of Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Covalent
organic
frameworks
(COFs)
have
recently
demonstrated
significant
potential
for
photocatalysis.
Optimizing
the
local
electronic
environment
in
COFs
has
been
considered
to
be
critical
enhancing
photocatalytic
activity.
Here,
we
report
a
one-pot
"grafting-to"
strategy
reprogram
configurations
of
series
isoreticular
multicomponent
by
introducing
electron-donating
or
electron-withdrawing
groups
into
pores
transform
photoinert
photoactive
and
form
intramolecular
donor–acceptor
(D-A)
structures.
Such
D-A
structures
enhanced
overall
hydrogen
peroxide
photoproduction
facilitating
charge
carrier
separation
optimizing
band
achieve
oxygen
reduction
reaction
water
oxidation
simultaneously.
Notably,
one
incorporated
with
2-aminothiazole
exhibits
production
rate
3701
μmol
g–1
h–1
solar-to-chemical
conversion
efficiency
0.13%
without
use
any
sacrificial
reagents,
it
100%
bacterial
killing
rates
remarkable
>90%
biofilm
removal
capability.
This
COF
modification
strategy,
which
not
reported
before,
offers
unique
approach
constructing
highly
active
photocatalysts
containing
great
future
design
antibacterial
therapies.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Abstract
The
interactions
exploration
between
microorganisms
and
nanostructures
are
pivotal
steps
toward
advanced
applications,
but
the
antibody‐level
bacteria
grabbing
is
limited
by
poor
understanding
of
interface
identification
mechanisms
in
small‐sized
systems.
Herein,
de
novo
design
a
bioinspired
hedgehog
artificial
mesoporous
nanostructure
(core–shell
Au@Pt
(mAPt))
proposed
to
investigate
association
topography
efficient
grabbing.
These
observations
indicate
that
virus‐like
spiky
compensates
for
obstacles
faced
materials
grabbing,
including
lack
requisite
microscopic
cavities
sufficient
contact
area.
Molecular
dynamics
simulation
reveals
with
heightened
mechano‐invasiveness
(6.56
×
10
3
KJ
mol
−1
)
facilitates
attributed
“mechanic
invasion”‐induced
hierarchical
dynamic
ranging
from
rough
surface
penetration
fixation.
Furthermore,
light
reflectance
finite
element
calculation
confirmed
mAPt
exhibits
near‐superblack
characteristic
plasmonic
hot
spot,
facilitating
enhanced
photothermal
conversion
power
dissipation
density
at
2.04
21
W
m
−3
.
After
integrating
response,
enables
applications
immunoassay
50‐fold
sensitivity
enhancement
over
99.99%
vitro
sterilization.
It
anticipated
this
novel
biomimetic
provides
deeper
promising
paradigm
combating.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Antibiotic-resistant
pathogens
pose
a
significant
global
public
health
challenge,
particularly
in
refractory
infections
associated
with
biofilms.
The
urgent
development
of
innovative,
safe,
and
therapeutically
adaptive
strategies
to
combat
these
resistant
biofilms
is
essential.
We
present
novel,
precise,
controllable
photodynamic
antibacterial
carbon
dot
(B-M-CD)
inspired
by
the
natural
properties
mulberry
leaf
bacterial
targeting
function
boric
acid.
This
photocatalytic
agent
exhibits
good
biocompatibility
utilizes
its
inherent
activities,
along
photoactivated
oxidase-mimicking
activity,
generate
reactive
oxygen
species
for
eradication
methicillin-resistant
Staphylococcus
aureus
(MRSA).
By
leveraging
reversible
covalent
binding
between
boronic
acid
groups
cis-diol
on
surfaces,
we
further
enhance
targeted
activity.
B-M-CDs
effectively
penetrate
extracellular
polymeric
substances
demonstrate
precise
effect,
allowing
localized
delivery
aimed
at
biofilm
inhibition
destruction.
Metabolomic
analyses
reveal
that
disrupt
amino
metabolism,
protein
synthesis,
electron
transport
chain,
energy
metabolism
MRSA.
In
vivo
experiments
confirm
this
photocatalyst
treats
MRSA-induced
wounds
an
efficacy
comparable
vancomycin
while
also
exhibiting
high
biocompatibility.
study
represents
first
photoactivated,
controllable,
carbon-based
nanozyme
derived
from
traditional
Chinese
herb,
leaf,
providing
novel
strategy
designing
intelligent
nanoagents
underscoring
their
potential
as
candidate
therapeutics
conditions
analogous
MRSA
infections.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
Abstract
The
escalating
threat
of
bacterial
infections,
especially
antibiotic‐resistant
strains,
highlights
the
need
for
efficient,
long‐term,
broad‐spectrum,
and
non‐antibiotic
disinfectants.
Here
a
biomimetic
nano‐disinfectant,
Au@ZnO
nano‐urchins
(Au@ZnO‐NUs)
is
introduced,
inspired
by
sea
urchin
morphology.
One
consisting
an
Au‐nanocore
(25
±
5
nm
in
diameter)
surrounded
16
2
ZnO‐nanospears
(length:
50
nm,
diameter:
14
6
nm)
screened
out
via
exhibiting
exceptional
antibacterial
efficacy.
Impressively,
this
Au@ZnO‐NU
shows
over
99.47%
effectiveness
against
7
typical
bacteria
including
methicillin‐resistant
Staphylococcus
aureus
(MRSA)
at
low
concentration
(<8
µg
mL
−1
)
with
effects
lasting
least
30
days.
underlying
bacteriostatic
mechanism
involves
multiple
pathways,
physical
penetration
walls,
ROS
over‐production,
membrane‐potential
dissipation,
ATP‐level
downregulation,
biofilm
deformation
obtained
from
both
experiment
transcriptomic‐analysis.
Moreover,
these
can
be
easily
applied
as
spray‐coating
on
any
surface,
creating
wash‐resist,
cicada‐wing‐like
nano‐spiky
array
layer.
Remarkably,
exhibits
excellent
anti‐bacterial
performance
MRSA‐infectedlarge
wound
mm)
healing
rat
models,
which
even
better
than
Vancomycin,
approaching
natural
rate
sterile
wounds.
This
study
offers
promising
candidate
daily
applications
advances
design
strategies.
