Biochemistry and Biophysics Reports, Год журнала: 2025, Номер 42, С. 101983 - 101983
Опубликована: Март 29, 2025
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 183, С. 117814 - 117814
Опубликована: Янв. 13, 2025
Язык: Английский
Процитировано
2
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.
Язык: Английский
Процитировано
2
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Сен. 28, 2024
Язык: Английский
Процитировано
14
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 15, 2025
Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.
Язык: Английский
Процитировано
1
Science Advances, Год журнала: 2025, Номер 11(7)
Опубликована: Фев. 14, 2025
Cuproptosis, a distinct cell death pathway, has been integrated into nanomedicine for disease theranostics. However, current nanosystems inducing cuproptosis rely on exogenous toxic copper ions, limiting the scope of biomaterials. Developing nanoplatforms that induce without holds substantial promise. Here, we engineered two-dimensional iron (Fe) single-atom–doped molybdenum disulfide (MoS 2 ) piezocatalyst (Fe-MoS tumor therapy. Incorporating single Fe atoms enhances MoS piezoelectric polarization via charge redistribution and modulates Mo oxidation states, enabling multifaceted enzymatic activities, including peroxidase-, glutathione oxidase–, oxidase-, catalase-like activities. Upon ultrasound stimulation, Fe-MoS nanocatalyst generates reactive oxygen species depletes synergistic piezocatalytic enzyocatalytic effects, disrupting ion homeostasis cuproptosis, concurrently triggering ferroptosis ferritinophagy, which collectively suppression. This study represents first paradigm to introduce copper-free initiating substantially advancing applications in
Язык: Английский
Процитировано
1
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(44), С. 30033 - 30045
Опубликована: Окт. 28, 2024
Cuproptosis, a recently identified form of copper-dependent cell death, shows promising tumor suppressive effects with minimal drug resistance. However, its therapeutic efficacy is hampered by dependence on copper ions and the glutathione (GSH)-rich microenvironment in tumors. Here, we have developed polyvalent aptamer nanodrug conjugates (termed CuPEs@PApt) nucleosome-like structure to improve cuproptosis therapy exploiting mitochondrial overload GSH depletion. Polyvalent (PApt), comprising epithelial adhesion molecule aptamers for targeting repetitive PolyT sequences chelation, facilitates efficient loading targeted delivery peroxide-Elesclomol nanodots (CuPEs). Upon internalization cells, Elesclomol released from CuPEs@PApt accumulates mitochondria initiate cuproptosis, while lysosomal degradation CuP generates exogenous Cu2+ H2O2, triggering Fenton-like reaction depletion enhance cuproptosis. In vitro vivo experiments confirm this strategy inducing immunogenic latter contributing activation antitumor immune response synergistic growth inhibition.
Язык: Английский
Процитировано
7
Biomaterials, Год журнала: 2024, Номер 313, С. 122805 - 122805
Опубликована: Сен. 3, 2024
Язык: Английский
Процитировано
5
Journal of Controlled Release, Год журнала: 2024, Номер 375, С. 249 - 268
Опубликована: Сен. 12, 2024
Язык: Английский
Процитировано
4
Materials Today Bio, Год журнала: 2024, Номер 29, С. 101326 - 101326
Опубликована: Ноя. 9, 2024
Ion interference, including intracellular copper (Cu) overload, disrupts cellular homeostasis, triggers mitochondrial dysfunction, and activates cell-specific death channels, highlighting its significant potential in cancer therapy. Nevertheless, the insufficient Cu ions transported by existing ionophores, which are small molecules with short blood half-lives, inevitably hamper effectiveness of cuproptosis. Herein, ESCu@HM nanoreactor, self-assembled from integration H-MnO
Язык: Английский
Процитировано
4
Theranostics, Год журнала: 2025, Номер 15(5), С. 1760 - 1786
Опубликована: Янв. 2, 2025
Smart biomaterials with active environmental responsiveness have attracted widespread attention in recent years. Previous studies on bioactive glass (BG) mainly focused the property of bioactivity, while little has been paid to smart response BG. Herein, we propose concept Bioactive Glass Composites (SBGC) which are capable actively responding endogenous disease microenvironment or exogenous physical stimuli, thereby enabling treatment tissue defect sites and ultimately promoting regeneration. In this review, characteristics SBGC different internal external environments described. Subsequently, applications complex repair tumors, infections, diabetes reviewed. By deeply analyzing progress fields, review will point out direction for research next-generation
Язык: Английский
Процитировано
0