Advances in Engineered Bacteria for Cancer Therapy
Precision medicine and engineering.,
Год журнала:
2025,
Номер
unknown, С. 100017 - 100017
Опубликована: Фев. 1, 2025
Язык: Английский
A Nano-Strategy for Advanced Triple-Negative Breast Cancer Therapy by Regulating Intratumoral Microbiota
Nano Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Intratumoral
microbiota
have
been
identified
as
a
component
of
the
tumor
microenvironment
that
regulates
metastatic
behavior
tumors.
They
serve
not
only
indicators
pathology
but
also
potential
drug
targets
in
cancer
therapy.
Herein,
multifunctional
nanoplatform
(DD@FEL)
is
prepared
by
combining
antibiotic
doxycycline
(DOXY)
can
combat
intratumoral
and
chemotherapeutic
doxorubicin
(DOX)
ergosterol-originated
liposome.
Specially,
ergosterol
utilized
substitute
for
cholesterol
liposomes
to
exert
pharmacological
activity.
Mechanistically,
DD@FEL
leveraged
DOXY
inhibit
metastasis
based
on
regulation
microbiota,
which
synergizes
with
effect
DOX,
eventually
inhibiting
progression
triple-negative
breast
(TNBC).
Verified
both
vitro
vivo,
effectively
exerts
cytotoxic
TNBC
cells,
delays
growth
primary
TNBC,
attenuates
development
its
lung
metastasis,
providing
promising
therapeutic
strategy
control
orthotopic
TNBC.
Язык: Английский
The metabolic dialogue between intratumoural microbes and cancer: implications for immunotherapy
EBioMedicine,
Год журнала:
2025,
Номер
115, С. 105708 - 105708
Опубликована: Апрель 22, 2025
Язык: Английский
Bacteria-Based Bioactive Materials for Tumor Immunotherapy
Precision medicine and engineering.,
Год журнала:
2024,
Номер
unknown, С. 100013 - 100013
Опубликована: Ноя. 1, 2024
Язык: Английский
Research trends and hotspots of intratumor microbiome: A comprehensive visualization and bibliometric study from 2012 to 2024
Chinese Medical Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
To
the
Editor:
As
early
as
in
mid-19th
century,
microbiologists
first
recognized
multiple
microorganisms
within
human
tumors.
Nevertheless,
perceptions
of
intratumor
microbiome
have
made
little
progression
during
50
years
20th
century
owing
to
contamination
interference,
experimental
irreproducibility,
and
technical
limitations.
Strikingly,
past
decade,
advances
detection
techniques
analytical
tools
been
opening
unprecedented
opportunities
widely
investigate
manifold
characteristics
low-biomass
host–microbe
interplays.
In
second
decade
21st
researchers
focusing
on
gradually
emerged.
Initially,
this
adventurous
perspective
failed
draw
much
attention
because
tumors
were
still
considered
sterile
mainstream
belief
at
that
time.
realized
significant
role
tumor
biology,
immunity,
metabolism
a
non-negligent
new
component
microenvironments
(TME),
soon
became
hot.
Gradually,
microbiomes
emerged
diagnostic
prognostic
biomarkers,
even
strenuous
endeavors
devoted
tapping
their
potential
therapeutic
targets.[1–5]
Yet,
it
remains
left
translate
microbes-based
tumor-specific
therapies
into
clinical
practice.
Therefore,
there
is
great
significance
delineating
research
status
evolution
trend
microbiome.
We
conducted
bibliometric
analysis
487
related
publications
extracted
from
Web
Science
Core
Collection
inception
April
11,
2024
[Supplementary
Methods
Supplementary
Figures
1
2,
https://links.lww.com/CM9/C186],
mapping
current
landscape
hope
proffering
fresh
clues
for
future
research.
There
blowout
annual
publications,
predictive
annual/cumulative
are
221
614,
respectively,
Figure
3,
https://links.lww.com/CM9/C186].
Fifty-six
countries
published
documents,
wherein
less
than
20%
them
contributed
more
10
4A
Table
1,
Most
cooperation
confined
Europe,
North
America,
handful
Asian
countries/institutions
4B–E,
China
has
leading
producer
7
out
top
productive
institutions
also
held
by
China.
But
United
States
continued
dominate
field
global
center
with
overwhelming
citations.
This
partially
recently
cut
striking
figure
4C,
E,
A
total
3505
authors
provided
84.9%
single
publication
5A,
Only
489
co-authorship
relationships
5B,
C,
Just
Ravid
Straussman
Jennifer
Wargo
concurrently
among
prolific
cited
Deborah
Nejman
endowed
higher
citations
H-index
but
does
not
possess
reflecting
his
stringent
quality
control
over
publications.
most
co-cited
author
5D,
The
come
prominence
last
couple
except
distributed
discontinuously
2018
2023
5E,
Included
sourced
232
journals,
14
journals
judged
core
6A,
highest
albeit
only
two
Cell
possesses
link
strength
despite
five
whereas
Cancers
6B
classified
4
clusters
6C,
Citing
chiefly
Molecular/Biology/Immunology
Medicine/Medical/Clinical,
called
frontiers;
Molecular/Biology/Genetics,
knowledge
base
6D,
Thirteen
documents
ranked
20
local
citation
score
(LCS)
(GCS)
4,
These
incipient
high
LCS
proffer
theoretical
basis
subsequent
exhaustive
study
biological
functions.
7A,
https://links.lww.com/CM9/C186
portrays
relationships,
while
7B,
demonstrates
document's
impact
field.
7C,
further
shows
relationship
LCS.
8A,
depicts
reference
co-citation
network,
forming
thorough
examinations
8B,
highly
references
since
2015,
many
continue
be
8C
5,
hotspots
already
shifted
initial
topics
(e.g.,
#12,
#17,
#21,
#23),
#0
pancreatic
cancer,
#1
electroporation,
#2
engineered
bacteria,
#5
microbiome-based
therapy,
etc.,
represent
hotspots.
Especially,
therapy
including
bacteria
generated
one
or
years.
burst
can
traced
back
Grivennikov
SI,
2012,
Nature,
latest
took
place
2021,
attributed
Li
S,
2017,
Microbiome
8D,
Notably,
Geller
LT,
experienced
strongest
burst.
Keyword
frequency
examined
word
clouds
heatmap
9A–C
6,
generally
evincing
emphasis.
relatively
homogeneous
before
principally
prostate
cancer
gender;
nevertheless,
suddenly
surged
2021
9D,
Specifically,
emergence
some
keywords
top-left
corner
diagnosis,
prognosis,
biomarker,
TME)
gained
2
years,
discernible
shift
orientation
endeavors,
diagnosis
prognosis
intense
interests.
Similarly,
metastasis,
metabolism,
immune
microenvironment,
evolved
salient
9E,
gut
microbiome,
enduring
recent
Colorectal
dysbiosis,
16s
rRNA
belong
Motor
Themes,
denoting
they
themes
maturity
9F,
Whereas
metastasis
belongs
Niche
indicating
well-developed
banal.
Conversely,
Basic
demonstrating
enough,
therefore
may
become
trends.
above
prefigures
trajectories,
encompassing
therapy.
Below,
we
will
elucidate
far-reaching
meaning
realm
implications
directions.
Correlation
between
microbiome:
Gut
could
main
origin
directly
invade
gastrointestinal
tissues
via
impaired
mucosa,
translocate
non-mucosal
organs,
such
pancreas
through
ducts.
Furthermore,
given
cells
immunocytes,
transported
form
fractions
intact
cell
migration.
conjectures
must
validated
holistic
metagenomic
sequencing
genetic
identification.
Apart
direct
association
microbial
translocation,
remote
communication
mediates
latent
connection.
indirectly
affect
TME
metabolites
system,
culminating
altering
modulate
microbiome?
Further
warranted
interplay
its
effects
TME.
Tumor
immunomodulation:
Intratumor
reshapes
microenvironment
(TIME)
modulating
pro-tumoral
antitumor
immunity.
microecology
facilitates
recruitment
activation
counteracts
Meanwhile,
augments
immunity
focus
activation,
exerts
inhibitory
immunocytes.
Although
exact
mechanisms
multitudinous
immunomodulation
yet
elucidated,
underlying
include
(1)
valid
presentation
antigens,
especially
antigens
mimicry
shared
antigens;
(2)
microbe-induced
immunogenic
death;
(3)
microbe-derived
metabolites,
(4)
pattern
recognition
receptor-mediated
adjuvanticity.
Collectively,
target
supporting
immunotherapy,
context-dependent
require
clarification
prior
translation.
It
topic
facing
grand
challenges
deserves
exploration.
Metabolic
regulation:
reprograms
convoluted
7,
play
double-edged
sword
TIME
non-negligible
mediators
interactions.
complicated
impacts
depend
several
factors,
type,
stage,
host
genotype,
specific
metabolite,
which
necessitates
study.
Targeting
metabolic
regulation
should
monumental
subject
research,
comprehensive
perception
microbe
enlighten
strategies.
Diagnosis
prognosis:
associated
clinicopathological
features
age,
gender,
subtypes,
histological
grade),
valuable
indicator
subtype
stratification,
staging
classification.
abundance
responses
outcomes,
promising
tool
prognosis.
Given
invasiveness
difficulty
obtaining
tissue
samples,
accumulating
studies
typically
utilize
alternative
sputum
bronchoalveolar
lavage
fluid.
tumor-associated
circulating
DNA,
biomarker
liquid
biopsy,
Additionally,
combining
multiple-omics
data
other
emerging
sampling
techniques,
ingestible
capsules
sampling,
favor
precise
Cancer
therapy:
multidimensional
plays
roles
determining
response
antineoplastic
therapies.
Consequently,
targeting
adjuvant
strategies
following
points:
eliminating
detrimental
carcinogenic
species;
fostering
beneficial
microbiome;
metabolite-based
intervention
reprogram
TIME;
ameliorate
chemotherapy,
radiotherapy;
(5)
microbe-inspired
drug
delivery.
particular,
technological
development
reformed
design
presents
preferential
tumors,
aggressive
penetration,
easy
recognition,
controllable
cytotoxicity.
genetically
release
products
trigger
reactions
handicapping
function
hitchhiking
targeted
delivery
immunostimulators,
toxins,
drugs.
somewhat
challenging
determine
optimal
dose
dosing
schedule
live
bacterial
substances,
administration
substances
risk
life-threatening
infections
sepsis.
combine
conventional
therapies,
ideas
upgrade
efficacy.
traditional
Chinese
medicine
successfully
applied
few
report
about
approach
provides
experience
speculate
triangular
interaction
medicine,
microbiota,
inevitable
limitations
Other
database-derived
non-English
omitted.
presented
temporal
limitation.
bibliometrics
constricted
metadata
rather
full-text
analysis.
these
would
alter
findings.
Overall,
visualization
explore
frontiers
According
systematical
analysis,
endows
additional
multivariate
divergent
an
attractive
target.
depict
microbiome-mediated
molecular
networks
environment.
Perhaps
eventual
destination
Funding
work
was
supported
National
Natural
Foundation
(No.
82150006),
Society
Clinical
Oncology
Research
(Nos.
Y-HR2017-117,
Y-HH202102-0060),
Beijing
Medical
Health
YWJKJJHKYJJ-F3046D),
Qujiang
District
Quzhou
City
Life
Oasis
Public
Service
Center
BJHA-CRP-040),
Wu
Jieping
320.6750.2023-05-10)
Yawen
Gao.
Conflicts
interest
None.
Язык: Английский
Intratumor microbiota and colorectal cancer: Comprehensive and lucid review
Chinese Journal of Cancer Research,
Год журнала:
2024,
Номер
36(6), С. 683 - 699
Опубликована: Янв. 1, 2024
As
a
key
component
of
tumor
microenvironment,
the
microbiota
has
gradually
played
role
in
cancer
research.
Particularly
colorectal
cancer,
specific
population
within
shows
strong
association
with
type.
Although
existence
and
potential
tumors
have
been
recognized,
associations
between
tissue
mechanism
action
still
need
to
be
further
explored.
This
paper
reviews
discovery,
origin,
emerging
intratumor
immune
microenvironment
systematically
outlines
oncogenic
metastasis-promoting
strategies
microbiota.
Moreover,
it
comprehensively
holistically
evaluates
therapeutic
prognostic
performance
on
basis
microbiota,
goal
providing
support
for
future
research
clinical
practice.
Язык: Английский