Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Год журнала: 2024, Номер 519, С. 216122 - 216122

Опубликована: Авг. 6, 2024

Язык: Английский

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Synergistic combinational photothermal therapy-based approaches for cancer treatment

FlatChem, Год журнала: 2025, Номер unknown, С. 100834 - 100834

Опубликована: Фев. 1, 2025

Язык: Английский

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A NIR‐II‐Emissive Organic Nanomedicine with Biomimetic Engineering for High‐Contrast Targeted Bioimaging and Multiple Phototherapies of Pancreatic Tumors

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 2, 2024

Abstract Recent advances are achieved in the design and development of efficient organic photosensitizers (PSs), especially with fluorescence imaging navigation second near‐infrared (NIR‐II, 1000–1700 nm) region. However, there simply a handful NIR‐II emissive PSs oxygen‐independent capability due to scarcity high‐performance NIR‐responsive materials targeted delivery. Herein, NIR‐II‐emissive nanomedicine biomimetic engineering for multiple phototherapies pancreatic tumors is reported. An A‐D‐A‐type conjugated small‐molecule TPC designed used prepare water‐dispersive nanoparticles, which demonstrated high efficiency type I II photodynamic performances, good photothermal conversion 57%, bright emission quantum yield 9.8% under 808 nm light irradiation. With cancer cell membrane camouflage, high‐resolution bioimaging whole‐body blood vessels tumors. Antitumor experiments tumor elimination biosafety This work versatile enhanced tumor‐targeting superior phototheranostics, providing feasible idea evolution theranostics.

Язык: Английский

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Facilely Achieving Near-Infrared-II J-Aggregates through Molecular Bending on a Donor–Acceptor Fluorophore for High-Performance Tumor Phototheranostics

ACS Nano, Год журнала: 2024, Номер unknown

Опубликована: Окт. 4, 2024

Constructing J-aggregated organic dyes represents a promising strategy for obtaining biomedical second near-infrared (NIR-II) emissive materials, as they exhibit red-shifted spectroscopic properties upon assembly into nanoparticles (NPs) in aqueous environments. However, currently available NIR-II J-aggregates primarily rely on specific molecular backbones with intricate design strategies and are susceptible to fluorescence quenching during assembly. A facile approach constructing bright using prevalent donor-acceptor (D-A) molecules is still lacking. In this study, we present method that transforms D-A by simply bending the molecule through introducing methyl group, enabling high-performance phototheranostics. The TAA-BT-CN exhibits hypsochromic-shift absorption forming H-aggregated NPs, while designed mTAA-BT-CN bent structure demonstrates bathochromic shift of over 100 nm leading much enhanced emission beyond 1100 nm. With respect its counterpart aggregation-caused (ACQ) phenomenon, NPs 7-fold increase owing their aggregation-induced (AIE) property well efficient generation heat reactive oxygen species under 808 light excitation. Finally, employed whole-body blood vessel imaging technology imaging-guided tumor phototherapies. This study will facilitate flourishing advancement based D-A-type molecules.

Язык: Английский

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Conversion Therapy Strategy: A Novel GPC3-Targeted Multimodal Organic Phototheranostics Platform for Mid-late-stage Hepatocellular Carcinoma

Materials Today Bio, Год журнала: 2025, Номер 30, С. 101442 - 101442

Опубликована: Янв. 2, 2025

Hepatocellular carcinoma (HCC) is typically diagnosed at intermediate to advanced stage, making surgical treatment unfeasible. Conversion therapy aims reduce tumor improve hepatic resection feasibility, and lower recurrence rates. Since traditional therapies are often accompanied by uncertainty of efficacy, there an urgent need explore new strategies. Near-infrared phototheranostics technology provides a way for HCC diagnosis its excellent optical properties. However, complex preparation poor biocompatibility probes limit clinical application. In this study, we developed fluorescence/magnetic resonance dual-modality imaging (FLI/MRI) as well photothermal/photodynamic (PTT/PDT) GPC3-targeted multifunctional probe, IR820-GPC3-Gd NPs (IGD NPs), the efficiency conversion HCC. The IGD were simply prepared with IR820 core. Conjugating HCC-specific targeting molecule GPC3 peptide MRI agent DOTA-Gd through click chemistry. target cells GPC3, releasing heat reactive oxygen species (ROS) under noninvasive 808 nm laser irradiation size achieve downstaging. High-sensitivity FLI/MRI precisely delineates boundaries, providing real-time navigation prognosis assessment. This novel probe offers feasible effective option

Язык: Английский

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Non‐Fused Conjugated Oligomer with Manipulated Intermolecular Charge Transfer for Highly Efficient Near‐Infrared Phototheranostics of Cancer

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Abstract Near‐infrared (NIR) phototheranostics, combining photoacoustic imaging (PAI) and photothermal therapy (PTT), show great promise for cancer diagnosis treatment. Organic molecules are excellent agents (PTAs) due to their strong NIR absorption biodegradability. Typically, achieving good response involves using fused‐ring backbones, which require complex synthesis yield lower production. In this work, 2F nanoparticles (NPs) reported as an organic phototheranostic agent with high responses, synthesized in just two simple steps 87% production efficient PAI‐guided PTT of cancer. Unlike traditional structures, is formed by joining donor acceptor moieties carbon–carbon bonds, simplifying increasing yield. Although isolated have absorption, forming NPs shifts the peak from 708 808 nm, comparable state‐of‐the‐art phototheranostics. This shift significant charge transfer between dimers, a single‐component charge‐transfer improved shown spectra theoretical studies. Finally, demonstrate successful under excitation anti‐tumor performance. work provides valuable insight into both photophysical performance PTAs, advancing development PTT.

Язык: Английский

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Mitoxantrone‐Encapsulated ZIF‐8 Enhances Chemo‐Immunotherapy via Amplified Immunogenic Cell Death

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Chemo‐immunotherapy, combining systemic chemotherapeutic drugs and immune checkpoint blockers, is a promising paradigm in cancer treatment. However, challenges such as limited induction of responses toxicity have hindered its clinical applications. Here, zeolite imidazolate framework‐8 (ZIF‐8) that encapsulates mitoxantrone (MIT), an cell death (ICD)‐inducing agent (MIT@ZIF‐8), synthesized using one‐pot aqueous‐phase process. ZIF‐8 serves dual‐functional nanomaterial for chemo‐immunotherapy: carrier to enhance tumor uptake MIT improved chemotherapy efficacy, pyroptosis inducer amplify MIT‐induced ICD augmented anti‐tumor responses. As result, vivo administration MIT@ZIF‐8 markedly inhibits growth both immunologically “hot” colon “cold” prostate cancer. Moreover, treatment increases the abundance cytotoxic CD8 + T cells reduces amount immunosuppressive regulatory tumors, thereby enhancing immunity sensitizing anti‐CTLA‐4 immunotherapy. In summary, offers highly translational approach chemo‐immunotherapy.

Язык: Английский

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Development of small-molecule NIR-II photothermal agents for image-guided tumor therapy

Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216549 - 216549

Опубликована: Фев. 27, 2025

Язык: Английский

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A PEGylated conjugated-BODIPY oligomer for NIR-II imaging-guided photothermal therapy

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

We have developed self-assembled nanoparticles (BODIPY 4 -PEG NPs) that exhibit excellent imaging performance and photothermal conversion efficiency.

Язык: Английский

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A cyanine fluorophore for imaging-guided tumor photodynamic and photothermal therapy under NIR-II light activation

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Язык: Английский

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