Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2024, Номер 325, С. 125107 - 125107
Опубликована: Сен. 7, 2024
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2025, Номер 529, С. 216456 - 216456
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
4
Coordination Chemistry Reviews, Год журнала: 2025, Номер 528, С. 216379 - 216379
Опубликована: Янв. 4, 2025
Язык: Английский
Процитировано
2
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
The development of long-wavelength near-infrared II (NIR-II, 900–1700 nm) dyes is highly desirable but challenging. To achieve both red-shifted absorption/emission and superior in vivo imaging capabilities, a donor–acceptor–donor (D–A–D) xanthene core was strategically modified by extending π-conjugated double bonds enhancing electron-donating properties. Two named VIX-1250 VIX-1450 were synthesized exhibited notably peaks at 942/1250 1098/1450 nm, respectively. Among them, demonstrated chemo- photostability even such long wavelengths. Fluorescent angiography using micelles enabled high-clarity blood vessel with remarkable signal-to-noise ratio (SNR), underscoring that the dye's large Stokes shift (352 nm), good brightness (13 M–1 cm–1), wavelength served as key factors for high-quality biosensing. Additionally, combined ICG dual-color achieved near-zero optical cross talk, enabling different organ labeling. This study provides new direction design organic dyes.
Язык: Английский
Процитировано
0
Research, Год журнала: 2024, Номер 8
Опубликована: Дек. 27, 2024
Fluorescence imaging, a highly sensitive molecular imaging modality, is being increasingly integrated into clinical practice. Imaging within the second near-infrared biological window (NIR-II; 1,000 to 1,700 nm), also referred as shortwave infrared, has received substantial attention because of its markedly reduced autofluorescence, deeper tissue penetration, and enhanced spatiotemporal resolution compared traditional (NIR) imaging. Indocyanine green (ICG), US Food Drug Administration-approved NIR fluorophore, long been used in applications, including blood vessel angiography, vascular perfusion monitoring, tumor detection. Recent advancements NIR-II technology have revitalized interest ICG, revealing extended tail fluorescence beyond nm reaffirming potential clinically translatable fluorophore for vivo theranostic applications diagnosing various diseases. This review emphasizes notable advances use ICG derivatives image-guided therapy from both fundamental perspectives. We provide concise conclusion discuss challenges future opportunities with using approved fluorophores.
Язык: Английский
Процитировано
4
Advanced Energy Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
Abstract There is a growing interest in fabricated organic material‐based photodiodes (OPDs) since they are lightweight, flexible, and cost‐effective to manufacture. Notably, exhibit near‐infrared photo‐sensing capabilities that self‐powered, feature attributed the tunable optical properties of semiconductor (OSC) materials. Nonetheless, application OPDs industry encounters challenges compared their inorganic counterparts, such as low sensitivity limited durability. In this study, self‐powered OPD using poly[4,8‐bis(5‐(2‐ethylhexyl)thiophen‐2‐yl)benzo [1,2‐b:4,5‐b′]dithiophene‐2,6‐diyl‐alt‐(4‐(2‐ethylhexyl)‐3‐fluorothieno[3,4‐b]thiophene‐)‐2‐carboxylate‐2‐6‐diyl)]:biaxial active layer phenyl‐C70‐butyric acid methyl ester (PTB7‐Th:PC 70 BM) an hole transport (HTL) composed poly(3,4‐ethylenedioxythiophene) poly(styrene sulfonate) (PPY:PSS) developed. These results highlight effectiveness PPY:PSS HTL, demonstrating distinct improvements efficiency, photosensitivity, photo‐detectivity, operational stability when weight ratio between PPY PSS 1:2.
Язык: Английский
Процитировано
0
Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112648 - 112648
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of the American Chemical Society, Год журнала: 2025, Номер unknown
Опубликована: Фев. 4, 2025
Organic fluorophores with near-infrared (NIR) emission and reduced molecular size are crucial for advancing bioimaging biosensing technologies. Traditional methods, such as conjugation expansion heteroatom engineering, often fail to reduce fluorophore without sacrificing NIR properties. Addressing this challenge, our study utilized quantum chemical calculations structure-property relationship analysis establish an iterative design approach enable precision engineering compact, single-benzene-based fluorophores. These newly developed exhibit emissions up 759 nm maintain weights low 192 g/mol, approximately 50% of that Cy7. Additionally, they display unique environmental sensitivity─nonemissive in aqueous solutions but highly emissive lipid environments. This property significantly enhances their utility wash-free imaging live cells. Our findings mark a substantial breakthrough paving the way more efficient adaptable methodologies.
Язык: Английский
Процитировано
0
Small, Год журнала: 2025, Номер unknown
Опубликована: Фев. 21, 2025
Abstract Allergic rhinitis (AR) is the most prevalent global health issue, affecting approximately 3 billion people, with its incidence increasing annually. The current first‐line pharmacotherapy for symptom relief has limited efficacy and often results in notable side effects. Here, aza‐BODIPY‐based nanoparticles (RH@NPs) are developed that exhibit mild photothermal therapy (PTT) type I photodynamic (PDT) capabilities. Enhanced intramolecular charge transfer induces NIR‐II absorption of photosensitizer (RH), facilitating deeper tissue penetration augmented AR therapy. Additionally, use an asymmetric donor–acceptor–acceptor′ configuration promotes self‐assembly RH, enhancing intersystem crossing ability enabling efficient photophysical activity. synergistic effects PTT (enhancing HSF1 DNA‐binding activity to inhibit epithelial‐mesenchymal transition by epigenetically regulating expression transition‐associated genes) PDT (activating NRF2 transcriptional stimulate antioxidant defense system) enable RH@NPs provide a superior therapeutic effect mouse model AR. This achieved mechanically reducing allergic response rather than merely alleviating symptoms. Notably, photosensitizer‐based physical demonstrates enhanced safety. study first successfully investigate application phototherapy elucidate mechanism action, offering novel, straightforward, treatment strategy
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2025, Номер 319, С. 123229 - 123229
Опубликована: Фев. 28, 2025
Язык: Английский
Процитировано
0
Chemosensors, Год журнала: 2025, Номер 13(3), С. 104 - 104
Опубликована: Март 13, 2025
H2O2 plays an important role in oxidative damage and redox signaling. Studies have shown that abnormal levels of are closely related to the development cancer. The tumor cells higher than normal cells. Thus, it is great importance develop a fluorescent probe monitor level vivo. This work reports new biotin-guided NIR probe, Bio-B-Cy, consisting boronic acid ester as H2O2-recognition site biotin binding site, which accelerates fluorescence response Bio-B-Cy exhibits good sensitivity selectivity toward H2O2. In addition, shows dose-dependent detection limit 0.14 μM. We further demonstrate could successfully detect receptor-positive cancer tissues. Based on results, has potential serve efficient tool for early diagnosis
Язык: Английский
Процитировано
0