Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
clinically
approved
therapeutic
modality
that
has
shown
great
potential
for
cancer
treatment.
However,
there
exist
two
major
problems
hindering
PDT
applications:
the
nonspecific
phototoxicity
requiring
patients
to
stay
in
dark
post‐PDT,
and
limited
photodynamic
efficiency.
Herein,
we
report
photo‐triggered
porphyrin
polyelectrolyte
nanoassembling
(photo‐triggered
PPN)
strategy,
which
photosensitizer
photoswitchable
energy
accepter
are
assembled
into
micelles
by
combined
force
of
charge
interaction
metal‐ligand
coordination.
The
polyelectrolyte‐based
PPN
exhibits
good
biocompatibility,
bestows
unique
“confining
isolated”
inner
microenvironment
fully
overcoming
π–π
stacking
porphyrins
with
significant
efficiency
(123‐fold
enhancement).
Due
high
Förster
resonance
transfer
(FRET)
(91.5
%)
between
photoswitch
closed‐form,
could
use
light
as
specific
trigger
modulate
closed‐
open‐form,
manipulate
1
O
2
generation
three
stages:
pre‐PDT
(quenching
generation),
during
(activating
post‐PDT
(silencing
generation).
This
de
novo
strategy
first
time
realized
remotely
manipulating
boosting
PDT,
well
resolving
critical
general
challenges
side
effects
from
phototoxicity.
Chemical Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
novel
all-in-one
phototheranostics
OTAB
was
synthesized
by
modifying
the
donor
and
regulating
band
gap
for
NIR-II
imaging-guided
synergistic
type-I
PDT/PTT
therapy.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Abstract
The
stacking
mode
in
aggregate
state
results
from
a
delicate
balance
of
supramolecular
interactions,
which
closely
affects
the
optoelectronic
properties
organic
π‐conjugated
systems.
Then,
managing
these
interactions
is
crucial
for
advancing
phototheranostics,
yet
remains
challenging.
A
subtle
strategy
involving
peripheral
phenyl
groups
debuted
herein
to
transform
X‐aggregated
SQ‐H
into
J‐aggregated
SQ‐Ph,
reorienting
intermolecular
dipole
while
rationally
modulating
π–π
interactions.
Co‐assembled
with
liposomes
(DSPE‐PEG2000),
SQ‐Ph
nanoparticles
(NPs)
exhibit
low
toxicity,
superior
biocompatibility,
and
bathochromic
shift
1064
nm
match‐excited
NIR‐II
region,
fluorescence
brightness
(ε
Φ
)
4129
M
−1
cm
photothermal
conversion
efficiency
(PCE)
48.3%.
Preliminary
vivo
experiments
demonstrate
that
NPs
achieve
signal‐to‐background
ratio
(SBR)
up
14.29
imaging
(FLI),
enabling
highly
efficient
therapy
(PTT)
tumors
guided
by
combined
photoacoustic
(PAI).
This
study
not
only
enriches
J‐aggregation
library
but
also
provides
paradigm
optimizing
photosensitizers
at
level.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
Photo-immunotherapy
is
one
of
the
most
promising
cancer
treatment
strategies.
As
immunotherapeutic
agents,
immune
checkpoint
blockade
antibodies
against
programmed
cell
death
protein
1
(PD-1)
or
ligand
(PD-L1)
exhibit
substantial
potential,
but
have
to
face
non-specific
distribution
and
subsequent
immune-related
adverse
events.
Meanwhile,
high-performance
phototheranostic
agents
concurrently
possessing
multiple
modalities
high
light-harvesting
capacity
are
really
attractive
highly
desired
as
touching
modules.
Herein,
a
win-win
strategy
that
integrates
molecule
design
targeted
module
preparation
developed
construct
high-powered
photo-immunotherapy
systems.
Specifically,
agent
(AOTTIT)
displaying
typical
aggregation-induced
fluorescence
extending
second
near-infrared
II
window,
well
outstanding
reactive
oxygen
species
heat
production
first
obtained
via
ingenious
design.
Notably,
AOTTIT
exhibits
record
molar
extinction
coefficient
among
reported
organic
multimodal
molecules.
PD-1
genetically
engineered
membrane-derived
nanovesicles
(PD-1/CMNVs)
prepared
both
nanocarriers
camouflage
nanoparticles,
yielding
multifunctional
photo-immunotherapeutic
(CMNPs/PD-1)
with
tumor-specific
active
homologous
targeting
ability.
The
distinct
suppression
primary
metastatic
lung
tumors
after
only
once
tumor
substantiated
synergistically
strengthened
efficiency
this
strategy.
Bioconjugate Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Fluorescence
imaging
technology
is
playing
increasing
roles
in
modern
personalized
and
precision
medicine.
Thanks
to
their
excellent
photophysical
properties,
organic
luminogens
featuring
aggregation-induced
emission
(AIE)
characteristics
(AIEgens)
have
attracted
considerable
attention
over
the
past
two
decades.
Because
of
superior
biocompatibility,
ease
processing
functionalization,
water
solubility,
high
responsiveness,
exceptional
signal-to-noise
ratio
(SNR)
for
biotargets,
AIE
bioconjugates,
formed
by
covalently
linking
AIEgens
with
biomolecules,
emerged
as
an
ideal
candidate
bioapplications.
In
this
review,
we
summarize
progress
preparation,
application
bioconjugates
last
five
years.
Moreover,
challenges
opportunities
are
also
briefly
discussed.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 9, 2025
Abstract
Bladder
cancer
is
a
common
urological
malignancy
characterized
by
high
morbidity,
recurrence
rate
and
mortality,
imposing
heavy
burdens
on
patients
mentally
financially.
The
research
pioneers
diagnostic
therapeutic
approach
that
integrates
second
near‐infrared
(NIR‐II)
multimodal
phototheranostic
platform
with
optical
fiber‐mediated
interventional
phototherapy
strategy,
to
implement
comprehensive
diagnosis
“inside‐out”
treatment
of
bladder
cancer.
proposed
molecule,
namely
BTO‐TTQ,
elaborately
designed
through
electron
donor/π‐bridge
engineering
demonstrates
satisfying
NIR‐II
emission
aggregation‐induced
features,
photothermal
conversion
efficiency,
prominent
generation
type
I
reactive
oxygen
species.
Quantum
chemical
calculations
molecular
dynamics
simulations
are
employed
deeply
elucidate
the
energy
dissipation
pathways
excited
state
impact
intramolecular
motion
their
photophysical
properties.
Furthermore,
under
guidance
fluorescent‐photoacoustic‐photothermal
trimodal
imaging,
hyaluronic
acid‐modified
BTO‐TTQ
nanoparticles
exhibit
exceptional
performance
in
for
air‐pouch
models.
This
study
thus
brings
new
insight
into
development
superior
versatile
phototheranostics
clinical
theranostics
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 15, 2025
Abstract
Fluorescent
surgical
navigation
is
a
clinically
approved
modality
that
has
shown
great
potential
for
cancer
treatment.
However,
its
application
in
lung
tumors
still
faces
long‐standing
challenges
because
the
location,
size,
and
shape
of
can
fluctuate
significantly
depending
on
lung's
gas
filling
or
expulsion
state.
This
leads
to
substantial
gap
between
preoperative
imaging
evaluation
intraoperative
feedback.
Herein,
Förster
resonance
energy
transfer
(FRET)‐mediated
aggregation‐induced
emission
(AIE)‐active
nanoprobe
TCM‐N&Cy&Fe@P
described
spatiotemporally
profiling
surgery
through
dual‐modal
magnetic
(MRI)/fluorescent
imaging.
strategy,
first
time,
effectively
addresses
information‐gap
across
pre‐,
intra‐,
post‐operative
stages
surgery:
MRI
provides
high
spatial
resolution
soft
tissue
images
assessment
cancer.
After
targeted
delivery
tumor
site,
disassembly
resulted
significant
enhancement
near‐infrared
fluorescence.
Such
AIE‐active
fluorescence
offers
temporal
precisely
recognizing
delineating
boundaries
freshly
excised
tissues
from
patients,
postoperatively
pathological
staining
with
tumor‐to‐normal
contrast.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 10, 2024
Photodynamic
therapy
(PDT)
is
a
clinically
approved
therapeutic
modality
that
has
shown
great
potential
for
cancer
treatment.
However,
there
exist
two
major
problems
hindering
PDT
applications:
the
nonspecific
phototoxicity
requiring
patients
to
stay
in
dark
post-PDT,
and
limited
photodynamic
efficiency.
Herein,
we
report
photo-triggered
porphyrin
polyelectrolyte
nanoassembling
(photo-triggered
PPN)
strategy,
which
photosensitizer
photoswitchable
energy
accepter
are
assembled
into
micelles
by
combined
force
of
charge
interaction
metal-ligand
coordination.
The
polyelectrolyte-based
PPN
exhibits
good
biocompatibility,
bestows
unique
"confining
isolated"
inner
microenvironment
fully
overcoming
π-π
stacking
porphyrins
with
significant
efficiency
(123-fold
enhancement).
Due
high
Förster
resonance
transfer
(FRET)
(91.5
%)
between
photoswitch
closed-form,
could
use
light
as
specific
trigger
modulate
closed-
open-form,
manipulate
